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Items: 1 to 20 of 44


RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.

López-Alonso JP, Kaminishi T, Kikuchi T, Hirata Y, Iturrioz I, Dhimole N, Schedlbauer A, Hase Y, Goto S, Kurita D, Muto A, Zhou S, Naoe C, Mills DJ, Gil-Carton D, Takemoto C, Himeno H, Fucini P, Connell SR.

Nucleic Acids Res. 2017 Jun 20;45(11):6945-6959. doi: 10.1093/nar/gkx324.


Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.

López-Alonso JP, Fabbretti A, Kaminishi T, Iturrioz I, Brandi L, Gil-Carton D, Gualerzi CO, Fucini P, Connell SR.

Nucleic Acids Res. 2017 Feb 28;45(4):2179-2187. doi: 10.1093/nar/gkw1251.


The Novel Aminomethylcycline Omadacycline Has High Specificity for the Primary Tetracycline-Binding Site on the Bacterial Ribosome.

Heidrich CG, Mitova S, Schedlbauer A, Connell SR, Fucini P, Steenbergen JN, Berens C.

Antibiotics (Basel). 2016 Sep 22;5(4). pii: E32. doi: 10.3390/antibiotics5040032.


Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding.

Fabbretti A, Schedlbauer A, Brandi L, Kaminishi T, Giuliodori AM, Garofalo R, Ochoa-Lizarralde B, Takemoto C, Yokoyama S, Connell SR, Gualerzi CO, Fucini P.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2286-95. doi: 10.1073/pnas.1521156113. Epub 2016 Apr 6.


Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.

Kaminishi T, Schedlbauer A, Fabbretti A, Brandi L, Ochoa-Lizarralde B, He CG, Milón P, Connell SR, Gualerzi CO, Fucini P.

Nucleic Acids Res. 2015 Nov 16;43(20):10015-25. doi: 10.1093/nar/gkv975. Epub 2015 Oct 12.


Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome.

Schedlbauer A, Kaminishi T, Ochoa-Lizarralde B, Dhimole N, Zhou S, López-Alonso JP, Connell SR, Fucini P.

Antimicrob Agents Chemother. 2015 May;59(5):2849-54. doi: 10.1128/AAC.04895-14. Epub 2015 Mar 9.


Solid-state NMR enhanced by dynamic nuclear polarization as a novel tool for ribosome structural biology.

Gelis I, Vitzthum V, Dhimole N, Caporini MA, Schedlbauer A, Carnevale D, Connell SR, Fucini P, Bodenhausen G.

J Biomol NMR. 2013 Jun;56(2):85-93. doi: 10.1007/s10858-013-9721-2. Epub 2013 May 21.


Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.

Ratje AH, Loerke J, Mikolajka A, Brünner M, Hildebrand PW, Starosta AL, Dönhöfer A, Connell SR, Fucini P, Mielke T, Whitford PC, Onuchic JN, Yu Y, Sanbonmatsu KY, Hartmann RK, Penczek PA, Wilson DN, Spahn CM.

Nature. 2010 Dec 2;468(7324):713-6. doi: 10.1038/nature09547.


Mass spectrometry defines the stoichiometry of ribosomal stalk complexes across the phylogenetic tree.

Gordiyenko Y, Videler H, Zhou M, McKay AR, Fucini P, Biegel E, Müller V, Robinson CV.

Mol Cell Proteomics. 2010 Aug;9(8):1774-83. doi: 10.1074/mcp.M000072-MCP201. Epub 2010 May 13.


PSRP1 is not a ribosomal protein, but a ribosome-binding factor that is recycled by the ribosome-recycling factor (RRF) and elongation factor G (EF-G).

Sharma MR, Dönhöfer A, Barat C, Marquez V, Datta PP, Fucini P, Wilson DN, Agrawal RK.

J Biol Chem. 2010 Feb 5;285(6):4006-14. doi: 10.1074/jbc.M109.062299. Epub 2009 Dec 4.


Probing side-chain dynamics of a ribosome-bound nascent chain using methyl NMR spectroscopy.

Hsu ST, Cabrita LD, Fucini P, Christodoulou J, Dobson CM.

J Am Chem Soc. 2009 Jun 24;131(24):8366-7. doi: 10.1021/ja902778n.


Structure, dynamics and folding of an immunoglobulin domain of the gelation factor (ABP-120) from Dictyostelium discoideum.

Hsu ST, Cabrita LD, Fucini P, Dobson CM, Christodoulou J.

J Mol Biol. 2009 May 15;388(4):865-79. doi: 10.1016/j.jmb.2009.02.063. Epub 2009 Mar 10.


A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation.

Connell SR, Topf M, Qin Y, Wilson DN, Mielke T, Fucini P, Nierhaus KH, Spahn CM.

Nat Struct Mol Biol. 2008 Sep;15(9):910-5.


The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning.

Wilson DN, Schluenzen F, Harms JM, Starosta AL, Connell SR, Fucini P.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13339-44. doi: 10.1073/pnas.0804276105. Epub 2008 Aug 29.


Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.

Harms JM, Wilson DN, Schluenzen F, Connell SR, Stachelhaus T, Zaborowska Z, Spahn CM, Fucini P.

Mol Cell. 2008 Apr 11;30(1):26-38. doi: 10.1016/j.molcel.2008.01.009.


Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins.

Sharma MR, Wilson DN, Datta PP, Barat C, Schluenzen F, Fucini P, Agrawal RK.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19315-20. Epub 2007 Nov 27.


Structural aspects of RbfA action during small ribosomal subunit assembly.

Datta PP, Wilson DN, Kawazoe M, Swami NK, Kaminishi T, Sharma MR, Booth TM, Takemoto C, Fucini P, Yokoyama S, Agrawal RK.

Mol Cell. 2007 Nov 9;28(3):434-45.


Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy.

Hsu ST, Fucini P, Cabrita LD, Launay H, Dobson CM, Christodoulou J.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16516-21. Epub 2007 Oct 10.


A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction.

Kaminishi T, Wilson DN, Takemoto C, Harms JM, Kawazoe M, Schluenzen F, Hanawa-Suetsugu K, Shirouzu M, Fucini P, Yokoyama S.

Structure. 2007 Mar;15(3):289-97.


Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors.

Connell SR, Takemoto C, Wilson DN, Wang H, Murayama K, Terada T, Shirouzu M, Rost M, Schüler M, Giesebrecht J, Dabrowski M, Mielke T, Fucini P, Yokoyama S, Spahn CM.

Mol Cell. 2007 Mar 9;25(5):751-64.

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