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A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage.

Brown SH, Eather SR, Freeman DJ, Meyer BJ, Mitchell TW.

PLoS One. 2016 Sep 29;11(9):e0163972. doi: 10.1371/journal.pone.0163972.


Coffee-Antihypertensive Drug Interaction: A Hemodynamic and Pharmacokinetic Study With Felodipine.

Bailey DG, Dresser GK, Urquhart BL, Freeman DJ, Arnold JM.

Am J Hypertens. 2016 Aug 1. pii: hpw081.


Maternal Plasma DHA Levels Increase Prior to 29 Days Post-LH Surge in Women Undergoing Frozen Embryo Transfer: A Prospective, Observational Study of Human Pregnancy.

Meyer BJ, Onyiaodike CC, Brown EA, Jordan F, Murray H, Nibbs RJ, Sattar N, Lyall H, Nelson SM, Freeman DJ.

J Clin Endocrinol Metab. 2016 Apr;101(4):1745-53. doi: 10.1210/jc.2015-3089.


Does high-density lipoprotein protect vascular function in healthy pregnancy?

Sulaiman WN, Caslake MJ, Delles C, Karlsson H, Mulder MT, Graham D, Freeman DJ.

Clin Sci (Lond). 2016 Apr 1;130(7):491-7. doi: 10.1042/CS20150475.


Optogenetic apoptosis: light-triggered cell death.

Hughes RM, Freeman DJ, Lamb KN, Pollet RM, Smith WJ, Lawrence DS.

Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12064-8. doi: 10.1002/anie.201506346.


Differential expression of microRNA-206 and its target genes in preeclampsia.

Akehurst C, Small HY, Sharafetdinova L, Forrest R, Beattie W, Brown CE, Robinson SW, McClure JD, Work LM, Carty DM, McBride MW, Freeman DJ, Delles C.

J Hypertens. 2015 Oct;33(10):2068-74. doi: 10.1097/HJH.0000000000000656.


Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer.

Mendell J, Freeman DJ, Feng W, Hettmann T, Schneider M, Blum S, Ruhe J, Bange J, Nakamaru K, Chen S, Tsuchihashi Z, von Pawel J, Copigneaux C, Beckman RA.

EBioMedicine. 2015 Feb 12;2(3):264-71. doi: 10.1016/j.ebiom.2015.02.005.


Enzymatic and non-enzymatic mechanisms of dimesna metabolism.

Cutler MJ, Velenosi TJ, Bodalia A, House AA, Urquhart BL, Freeman DJ.

Amino Acids. 2015 Mar;47(3):511-23. doi: 10.1007/s00726-014-1882-0.


Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother-offspring pairs: findings from a prospective pregnancy cohort.

Lawlor DA, West J, Fairley L, Nelson SM, Bhopal RS, Tuffnell D, Freeman DJ, Wright J, Whitelaw DC, Sattar N.

Diabetologia. 2014 Dec;57(12):2492-500. doi: 10.1007/s00125-014-3386-6.


In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy.

Huda SS, Forrest R, Paterson N, Jordan F, Sattar N, Freeman DJ.

Hypertension. 2014 May;63(5):1094-101. doi: 10.1161/HYPERTENSIONAHA.113.01824.


Co-occurrence of anaerobic bacteria in colorectal carcinomas.

Warren RL, Freeman DJ, Pleasance S, Watson P, Moore RA, Cochrane K, Allen-Vercoe E, Holt RA.

Microbiome. 2013 May 15;1(1):16. doi: 10.1186/2049-2618-1-16.


A phase 2 randomized trial of paclitaxel and carboplatin with or without panitumumab for first-line treatment of advanced non-small-cell lung cancer.

Crawford J, Swanson P, Schwarzenberger P, Sandler A, Prager D, Zhang K, Freeman DJ, Johnson CW, Krishnan K, Johnson D.

J Thorac Oncol. 2013 Dec;8(12):1510-8. doi: 10.1097/JTO.0b013e3182a7d1da.


Gene expression profiles can predict panitumumab monotherapy responsiveness in human tumor xenograft models.

Boedigheimer MJ, Freeman DJ, Kiaei P, Damore MA, Radinsky R.

Neoplasia. 2013 Feb;15(2):125-32.


Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester.

Meyer BJ, Stewart FM, Brown EA, Cooney J, Nilsson S, Olivecrona G, Ramsay JE, Griffin BA, Caslake MJ, Freeman DJ.

J Clin Endocrinol Metab. 2013 Feb;98(2):643-52. doi: 10.1210/jc.2012-3481.


Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies.

Hodson L, Neville M, Chong MF, Rogers I, Huda SS, Freeman DJ, Frayn KN, Fielding BA.

Nutr Metab Cardiovasc Dis. 2013 Nov;23(11):1128-33. doi: 10.1016/j.numecd.2012.11.003.


Derivation of HLA types from shotgun sequence datasets.

Warren RL, Choe G, Freeman DJ, Castellarin M, Munro S, Moore R, Holt RA.

Genome Med. 2012 Dec 10;4(12):95. doi: 10.1186/gm396.


Endothelial FOS expression and pre-eclampsia.

Mackenzie RM, Sandrim VC, Carty DM, McClure JD, Freeman DJ, Dominiczak AF, McBride MW, Delles C.

BJOG. 2012 Dec;119(13):1564-71. doi: 10.1111/1471-0528.12016.


Preeclampsia is associated with compromised maternal synthesis of long-chain polyunsaturated fatty acids, leading to offspring deficiency.

Mackay VA, Huda SS, Stewart FM, Tham K, McKenna LA, Martin I, Jordan F, Brown EA, Hodson L, Greer IA, Meyer BJ, Freeman DJ.

Hypertension. 2012 Oct;60(4):1078-85. doi: 10.1161/HYPERTENSIONAHA.112.197897.


Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.

Norman MH, Andrews KL, Bo YY, Booker SK, Caenepeel S, Cee VJ, D'Angelo ND, Freeman DJ, Herberich BJ, Hong FT, Jackson CL, Jiang J, Lanman BA, Liu L, McCarter JD, Mullady EL, Nishimura N, Pettus LH, Reed AB, Miguel TS, Smith AL, Stec MM, Tadesse S, Tasker A, Aidasani D, Zhu X, Subramanian R, Tamayo NA, Wang L, Whittington DA, Wu B, Wu T, Wurz RP, Yang K, Zalameda L, Zhang N, Hughes PE.

J Med Chem. 2012 Sep 13;55(17):7796-816. doi: 10.1021/jm300846z. Erratum in: J Med Chem. 2012 Oct 25;55(20):8975.


Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.

Wurz RP, Liu L, Yang K, Nishimura N, Bo Y, Pettus LH, Caenepeel S, Freeman DJ, McCarter JD, Mullady EL, Miguel TS, Wang L, Zhang N, Andrews KL, Whittington DA, Jiang J, Subramanian R, Hughes PE, Norman MH.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5714-20. doi: 10.1016/j.bmcl.2012.06.078.

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