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Items: 1 to 20 of 690

1.

Capturing Three-Dimensional Genome Organization in Individual Cells by Single-Cell Hi-C.

Nagano T, Wingett SW, Fraser P.

Methods Mol Biol. 2017;1654:79-97. doi: 10.1007/978-1-4939-7231-9_6.

PMID:
28986784
2.

Engineering of tomato for the sustainable production of ketocarotenoids and its evaluation in aquaculture feed.

Nogueira M, Enfissi EMA, Martínez Valenzuela ME, Menard GN, Driller RL, Eastmond PJ, Schuch W, Sandmann G, Fraser PD.

Proc Natl Acad Sci U S A. 2017 Sep 25. pii: 201708349. doi: 10.1073/pnas.1708349114. [Epub ahead of print]

PMID:
28973873
3.

Chromosome contacts in activated T cells identify autoimmune disease candidate genes.

Burren OS, Rubio García A, Javierre BM, Rainbow DB, Cairns J, Cooper NJ, Lambourne JJ, Schofield E, Castro Dopico X, Ferreira RC, Coulson R, Burden F, Rowlston SP, Downes K, Wingett SW, Frontini M, Ouwehand WH, Fraser P, Spivakov M, Todd JA, Wicker LS, Cutler AJ, Wallace C.

Genome Biol. 2017 Sep 4;18(1):165. doi: 10.1186/s13059-017-1285-0.

4.

Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults.

Laws SM, Gaskin S, Woodfield A, Srikanth V, Bruce D, Fraser PE, Porter T, Newsholme P, Wijesekara N, Burnham S, Doré V, Li QX, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL, Martins RN, Verdile G.

Sci Rep. 2017 Aug 29;7(1):9766. doi: 10.1038/s41598-017-09577-4.

5.

Creating plant molecular factories for industrial and nutritional isoprenoid production.

Nogueira M, Enfissi EM, Almeida J, Fraser PD.

Curr Opin Biotechnol. 2017 Aug 21;49:80-87. doi: 10.1016/j.copbio.2017.08.002. [Epub ahead of print] Review.

PMID:
28837945
6.

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

Wang H, Williams D, Griffin J, Saito T, Saido TC, Fraser PE, Rogaeva E, Schmitt-Ulms G.

PLoS One. 2017 Aug 23;12(8):e0182844. doi: 10.1371/journal.pone.0182844. eCollection 2017.

7.

Amyloid-β and islet amyloid pathologies link Alzheimer disease and type 2 diabetes in a transgenic model.

Wijesekara N, Ahrens R, Sabale M, Wu L, Ha K, Verdile G, Fraser PE.

FASEB J. 2017 Aug 14. pii: fj.201700431R. doi: 10.1096/fj.201700431R. [Epub ahead of print]

PMID:
28808140
8.

Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation.

Rubin AJ, Barajas BC, Furlan-Magaril M, Lopez-Pajares V, Mumbach MR, Howard I, Kim DS, Boxer LD, Cairns J, Spivakov M, Wingett SW, Shi M, Zhao Z, Greenleaf WJ, Kundaje A, Snyder M, Chang HY, Fraser P, Khavari PA.

Nat Genet. 2017 Oct;49(10):1522-1528. doi: 10.1038/ng.3935. Epub 2017 Aug 14.

PMID:
28805829
9.

Platelet function is modified by common sequence variation in megakaryocyte super enhancers.

Petersen R, Lambourne JJ, Javierre BM, Grassi L, Kreuzhuber R, Ruklisa D, Rosa IM, Tomé AR, Elding H, van Geffen JP, Jiang T, Farrow S, Cairns J, Al-Subaie AM, Ashford S, Attwood A, Batista J, Bouman H, Burden F, Choudry FA, Clarke L, Flicek P, Garner SF, Haimel M, Kempster C, Ladopoulos V, Lenaerts AS, Materek PM, McKinney H, Meacham S, Mead D, Nagy M, Penkett CJ, Rendon A, Seyres D, Sun B, Tuna S, van der Weide ME, Wingett SW, Martens JH, Stegle O, Richardson S, Vallier L, Roberts DJ, Freson K, Wernisch L, Stunnenberg HG, Danesh J, Fraser P, Soranzo N, Butterworth AS, Heemskerk JW, Turro E, Spivakov M, Ouwehand WH, Astle WJ, Downes K, Kostadima M, Frontini M.

Nat Commun. 2017 Jul 13;8:16058. doi: 10.1038/ncomms16058.

10.

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent.

Puzzo D, Piacentini R, Fá M, Gulisano W, Li Puma DD, Staniszewski A, Zhang H, Tropea MR, Cocco S, Palmeri A, Fraser P, D'Adamio L, Grassi C, Arancio O.

Elife. 2017 Jul 11;6. pii: e26991. doi: 10.7554/eLife.26991.

11.

Cell-cycle dynamics of chromosomal organization at single-cell resolution.

Nagano T, Lubling Y, Várnai C, Dudley C, Leung W, Baran Y, Mendelson Cohen N, Wingett S, Fraser P, Tanay A.

Nature. 2017 Jul 5;547(7661):61-67. doi: 10.1038/nature23001.

PMID:
28682332
12.

Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours.

Harewood L, Kishore K, Eldridge MD, Wingett S, Pearson D, Schoenfelder S, Collins VP, Fraser P.

Genome Biol. 2017 Jun 27;18(1):125. doi: 10.1186/s13059-017-1253-8.

13.

Successful Application of Whole Genome Sequencing in a Medical Genetics Clinic.

Bick D, Fraser PC, Gutzeit MF, Harris JM, Hambuch TM, Helbling DC, Jacob HJ, Kersten JN, Leuthner SR, May T, North PE, Prisco SZ, Schuler BA, Shimoyama M, Strong KA, Van Why SK, Veith R, Verbsky J, Weborg AM Jr, Wilk BM, Willoughby RE Jr, Worthey EA, Dimmock DP.

J Pediatr Genet. 2017 Jun;6(2):61-76. doi: 10.1055/s-0036-1593968. Epub 2016 Nov 28.

PMID:
28496993
14.

Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation.

Siersbæk R, Madsen JGS, Javierre BM, Nielsen R, Bagge EK, Cairns J, Wingett SW, Traynor S, Spivakov M, Fraser P, Mandrup S.

Mol Cell. 2017 May 4;66(3):420-435.e5. doi: 10.1016/j.molcel.2017.04.010.

PMID:
28475875
15.

Role of atmospheric oxidation in recent methane growth.

Rigby M, Montzka SA, Prinn RG, White JWC, Young D, O'Doherty S, Lunt MF, Ganesan AL, Manning AJ, Simmonds PG, Salameh PK, Harth CM, Mühle J, Weiss RF, Fraser PJ, Steele LP, Krummel PB, McCulloch A, Park S.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5373-5377. doi: 10.1073/pnas.1616426114. Epub 2017 Apr 17.

PMID:
28416657
16.

GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data.

Mifsud B, Martincorena I, Darbo E, Sugar R, Schoenfelder S, Fraser P, Luscombe NM.

PLoS One. 2017 Apr 5;12(4):e0174744. doi: 10.1371/journal.pone.0174744. eCollection 2017. Erratum in: PLoS One. 2017 May 3;12 (5):e0177280.

17.

Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.

Freire-Pritchett P, Schoenfelder S, Várnai C, Wingett SW, Cairns J, Collier AJ, García-Vílchez R, Furlan-Magaril M, Osborne CS, Fraser P, Rugg-Gunn PJ, Spivakov M.

Elife. 2017 Mar 23;6. pii: e21926. doi: 10.7554/eLife.21926.

18.

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins.

Bharadwaj P, Wijesekara N, Liyanapathirana M, Newsholme P, Ittner L, Fraser P, Verdile G.

J Alzheimers Dis. 2017;59(2):421-432. doi: 10.3233/JAD-161192.

PMID:
28269785
19.

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes.

Aymard F, Aguirrebengoa M, Guillou E, Javierre BM, Bugler B, Arnould C, Rocher V, Iacovoni JS, Biernacka A, Skrzypczak M, Ginalski K, Rowicka M, Fraser P, Legube G.

Nat Struct Mol Biol. 2017 Apr;24(4):353-361. doi: 10.1038/nsmb.3387. Epub 2017 Mar 6.

20.

The Formation and Sequestration of Nonendogenous Ketocarotenoids in Transgenic Nicotiana glauca.

Mortimer CL, Misawa N, Perez-Fons L, Robertson FP, Harada H, Bramley PM, Fraser PD.

Plant Physiol. 2017 Mar;173(3):1617-1635. doi: 10.1104/pp.16.01297. Epub 2017 Jan 30.

PMID:
28153925

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