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Items: 1 to 20 of 123

1.

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes.

Ai R, Laragione T, Hammaker D, Boyle DL, Wildberg A, Maeshima K, Palescandolo E, Krishna V, Pocalyko D, Whitaker JW, Bai Y, Nagpal S, Bachman KE, Ainsworth RI, Wang M, Ding B, Gulko PS, Wang W, Firestein GS.

Nat Commun. 2018 May 15;9(1):1921. doi: 10.1038/s41467-018-04310-9.

2.

A multisite study of performance drivers among institutional review boards.

Caligiuri M, Allen K, Buscher N, Denney L, Gates C, Kantelo K, Magit A, Sak R, Firestein GS, Fontanesi J.

J Clin Transl Sci. 2017 Jun;1(3):192-197. doi: 10.1017/cts.2017.8. Epub 2017 Jul 24.

3.

PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints.

Hong SS, Marotte H, Courbon G, Firestein GS, Boulanger P, Miossec P.

Nat Commun. 2017 Jul 27;8(1):146. doi: 10.1038/s41467-017-00142-1.

4.

Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis.

Kim KW, Kim BM, Lee KA, Lee SH, Firestein GS, Kim HR.

Sci Rep. 2017 Apr 26;7(1):1197. doi: 10.1038/s41598-017-01101-y.

5.

Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.

Doody KM, Bottini N, Firestein GS.

Epigenomics. 2017 Apr;9(4):479-492. doi: 10.2217/epi-2016-0151. Epub 2017 Mar 21. Review.

6.

Immunopathogenesis of Rheumatoid Arthritis.

Firestein GS, McInnes IB.

Immunity. 2017 Feb 21;46(2):183-196. doi: 10.1016/j.immuni.2017.02.006. Review.

7.

LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis.

Hammaker D, Whitaker JW, Maeshima K, Boyle DL, Ekwall AH, Wang W, Firestein GS.

Arthritis Rheumatol. 2016 Nov;68(11):2637-2645. doi: 10.1002/art.39746.

8.

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes.

Rhead B, Holingue C, Cole M, Shao X, Quach HL, Quach D, Shah K, Sinclair E, Graf J, Link T, Harrison R, Rahmani E, Halperin E, Wang W, Firestein GS, Barcellos LF, Criswell LA.

Arthritis Rheumatol. 2017 Mar;69(3):550-559. doi: 10.1002/art.39952.

9.

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes.

Ai R, Hammaker D, Boyle DL, Morgan R, Walsh AM, Fan S, Firestein GS, Wang W.

Nat Commun. 2016 Jun 10;7:11849. doi: 10.1038/ncomms11849.

10.

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.

Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS.

JCI Insight. 2016 May 19;1(7). pii: e86580.

11.

Cellular electrophysiological principles that modulate secretion from synovial fibroblasts.

Clark RB, Schmidt TA, Sachse FB, Boyle D, Firestein GS, Giles WR.

J Physiol. 2017 Feb 1;595(3):635-645. doi: 10.1113/JP270209. Epub 2017 Jan 5. Review.

12.

Metabolomics in rheumatic diseases: desperately seeking biomarkers.

Guma M, Tiziani S, Firestein GS.

Nat Rev Rheumatol. 2016 May;12(5):269-81. doi: 10.1038/nrrheum.2016.1. Epub 2016 Mar 3. Review.

13.

Computationally expanding infinium HumanMethylation450 BeadChip array data to reveal distinct DNA methylation patterns of rheumatoid arthritis.

Fan S, Li C, Ai R, Wang M, Firestein GS, Wang W.

Bioinformatics. 2016 Jun 15;32(12):1773-8. doi: 10.1093/bioinformatics/btw089. Epub 2016 Feb 15.

14.

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442.

15.

Correction: Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets.

Whitaker JW, Boyle DL, Bartok B, Ball ST, Gay S, Wang W, Firestein GS.

PLoS One. 2015 Aug 19;10(8):e0136334. doi: 10.1371/journal.pone.0136334. eCollection 2015. No abstract available.

16.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.

Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N.

Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

17.

Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets.

Whitaker JW, Boyle DL, Bartok B, Ball ST, Gay S, Wang W, Firestein GS.

PLoS One. 2015 Apr 22;10(4):e0124254. doi: 10.1371/journal.pone.0124254. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0136334.

18.

DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis.

Ai R, Whitaker JW, Boyle DL, Tak PP, Gerlag DM, Wang W, Firestein GS.

Arthritis Rheumatol. 2015 Jul;67(7):1978-80. doi: 10.1002/art.39123. No abstract available.

19.

Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.

Schepetkin IA, Kirpotina LN, Hammaker D, Kochetkova I, Khlebnikov AI, Lyakhov SA, Firestein GS, Quinn MT.

J Pharmacol Exp Ther. 2015 Jun;353(3):505-16. doi: 10.1124/jpet.114.220251. Epub 2015 Mar 17.

20.

The Rheumatoid Arthritis Risk Gene LBH Regulates Growth in Fibroblast-like Synoviocytes.

Ekwall AK, Whitaker JW, Hammaker D, Bugbee WD, Wang W, Firestein GS.

Arthritis Rheumatol. 2015 May;67(5):1193-202. doi: 10.1002/art.39060.

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