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Items: 1 to 20 of 73


Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease.

Wang L, Xia J, Li J, Hagemann TL, Jones JR, Fraenkel E, Weitz DA, Zhang SC, Messing A, Feany MB.

Nat Commun. 2018 May 15;9(1):1899. doi: 10.1038/s41467-018-04269-7.


α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton.

Ordonez DG, Lee MK, Feany MB.

Neuron. 2018 Jan 3;97(1):108-124.e6. doi: 10.1016/j.neuron.2017.11.036. Epub 2017 Dec 14.


A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.

Bardai FH, Wang L, Mutreja Y, Yenjerla M, Gamblin TC, Feany MB.

J Neurosci. 2018 Jan 3;38(1):108-119. doi: 10.1523/JNEUROSCI.1550-17.2017. Epub 2017 Nov 14.


Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.

Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL.

Neurobiol Dis. 2017 Oct;106:191-204. doi: 10.1016/j.nbd.2017.07.007. Epub 2017 Jul 12.


Defective Phagocytic Corpse Processing Results in Neurodegeneration and Can Be Rescued by TORC1 Activation.

Etchegaray JI, Elguero EJ, Tran JA, Sinatra V, Feany MB, McCall K.

J Neurosci. 2016 Mar 16;36(11):3170-83. doi: 10.1523/JNEUROSCI.1912-15.2016.


An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease.

Wang L, Hagemann TL, Messing A, Feany MB.

J Neurosci. 2016 Feb 3;36(5):1445-55. doi: 10.1523/JNEUROSCI.0256-15.2016.


Lamin Dysfunction Mediates Neurodegeneration in Tauopathies.

Frost B, Bardai FH, Feany MB.

Curr Biol. 2016 Jan 11;26(1):129-36. doi: 10.1016/j.cub.2015.11.039. Epub 2015 Dec 24.


Nitric oxide mediates glial-induced neurodegeneration in Alexander disease.

Wang L, Hagemann TL, Kalwa H, Michel T, Messing A, Feany MB.

Nat Commun. 2015 Nov 26;6:8966. doi: 10.1038/ncomms9966.


Connecting the dots between tau dysfunction and neurodegeneration.

Frost B, Götz J, Feany MB.

Trends Cell Biol. 2015 Jan;25(1):46-53. doi: 10.1016/j.tcb.2014.07.005. Epub 2014 Aug 26. Review.


Glia are critical for the neuropathology of complex I deficiency in Drosophila.

Hegde VR, Vogel R, Feany MB.

Hum Mol Genet. 2014 Sep 1;23(17):4686-92. doi: 10.1093/hmg/ddu188. Epub 2014 Apr 23.


Tau promotes neurodegeneration through global chromatin relaxation.

Frost B, Hemberg M, Lewis J, Feany MB.

Nat Neurosci. 2014 Mar;17(3):357-66. doi: 10.1038/nn.3639. Epub 2014 Jan 26.


Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms.

Shulman JM, Imboywa S, Giagtzoglou N, Powers MP, Hu Y, Devenport D, Chipendo P, Chibnik LB, Diamond A, Perrimon N, Brown NH, De Jager PL, Feany MB.

Hum Mol Genet. 2014 Feb 15;23(4):870-7. doi: 10.1093/hmg/ddt478. Epub 2013 Sep 25.


A genetic basis for the variable effect of smoking/nicotine on Parkinson's disease.

Hill-Burns EM, Singh N, Ganguly P, Hamza TH, Montimurro J, Kay DM, Yearout D, Sheehan P, Frodey K, McLear JA, Feany MB, Hanes SD, Wolfgang WJ, Zabetian CP, Factor SA, Payami H.

Pharmacogenomics J. 2013 Dec;13(6):530-7. doi: 10.1038/tpj.2012.38. Epub 2012 Oct 2.


Tau promotes neurodegeneration via DRP1 mislocalization in vivo.

DuBoff B, Götz J, Feany MB.

Neuron. 2012 Aug 23;75(4):618-32. doi: 10.1016/j.neuron.2012.06.026.


Mediators of a long-term movement abnormality in a Drosophila melanogaster model of classic galactosemia.

Ryan EL, DuBoff B, Feany MB, Fridovich-Keil JL.

Dis Model Mech. 2012 Nov;5(6):796-803. doi: 10.1242/dmm.009050. Epub 2012 Jun 26.


Alexander disease.

Messing A, Brenner M, Feany MB, Nedergaard M, Goldman JE.

J Neurosci. 2012 Apr 11;32(15):5017-23. doi: 10.1523/JNEUROSCI.5384-11.2012. No abstract available.


A neuroprotective role for the DNA damage checkpoint in tauopathy.

Khurana V, Merlo P, DuBoff B, Fulga TA, Sharp KA, Campbell SD, Götz J, Feany MB.

Aging Cell. 2012 Apr;11(2):360-2. doi: 10.1111/j.1474-9726.2011.00778.x. Epub 2012 Feb 1.


Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model.

Wang L, Colodner KJ, Feany MB.

J Neurosci. 2011 Feb 23;31(8):2868-77. doi: 10.1523/JNEUROSCI.3410-10.2011.


Functional screening of Alzheimer pathology genome-wide association signals in Drosophila.

Shulman JM, Chipendo P, Chibnik LB, Aubin C, Tran D, Keenan BT, Kramer PL, Schneider JA, Bennett DA, Feany MB, De Jager PL.

Am J Hum Genet. 2011 Feb 11;88(2):232-8. doi: 10.1016/j.ajhg.2011.01.006. Epub 2011 Feb 3.


Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy.

Colodner KJ, Feany MB.

J Neurosci. 2010 Dec 1;30(48):16102-13. doi: 10.1523/JNEUROSCI.2491-10.2010.

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