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Items: 1 to 20 of 254


Mechanosensitive Piezo Channels in the Gastrointestinal Tract.

Alcaino C, Farrugia G, Beyder A.

Curr Top Membr. 2017;79:219-244. doi: 10.1016/bs.ctm.2016.11.003. Epub 2017 Jan 7.


Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying.

Hayashi Y, Toyomasu Y, Saravanaperumal SA, Bardsley MR, Smestad JA, Lorincz A, Eisenman ST, Cipriani G, Nelson Holte MH, Al Khazal FJ, Syed SA, Gajdos GB, Choi KM, Stoltz GJ, Miller KE, Kendrick ML, Rubin BP, Gibbons SJ, Bharucha AE, Linden DR, Maher LJ 3rd, Farrugia G, Ordog T.

Gastroenterology. 2017 Apr 21. pii: S0016-5085(17)35523-3. doi: 10.1053/j.gastro.2017.04.020. [Epub ahead of print]


Experience with precision genomics and tumor board, indicates frequent target identification, but barriers to delivery.

Bryce AH, Egan JB, Borad MJ, Stewart AK, Nowakowski GS, Chanan-Khan A, Patnaik MM, Ansell SM, Banck MS, Robinson SI, Mansfield AS, Klee EW, Oliver GR, McCormick JB, Huneke NE, Tagtow CM, Jenkins RB, Rumilla KM, Kerr SE, Kocher JA, Beck SA, Fernandez-Zapico ME, Farrugia G, Lazaridis KN, McWilliams RR.

Oncotarget. 2017 Apr 18;8(16):27145-27154. doi: 10.18632/oncotarget.16057.


Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production.

Bhattarai Y, Schmidt BA, Linden DR, Larson ED, Grover M, Beyder A, Farrugia G, Kashyap PC.

Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G80-G87. doi: 10.1152/ajpgi.00448.2016. Epub 2017 Apr 13.


EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.

Strege PR, Gibbons SJ, Mazzone A, Bernard CE, Beyder A, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G572-G579. doi: 10.1152/ajpgi.00429.2016. Epub 2017 Mar 23.


Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function.

Peters SA, Edogawa S, Sundt WJ, Dyer RB, Dalenberg DA, Mazzone A, Singh RJ, Moses N, Smyrk TC, Weber C, Linden DR, MacNaughton WK, Turner JR, Camilleri M, Katzka DA, Farrugia G, Grover M.

Am J Gastroenterol. 2017 Jun;112(6):913-923. doi: 10.1038/ajg.2017.48. Epub 2017 Mar 21.


Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models.

Touw K, Ringus DL, Hubert N, Wang Y, Leone VA, Nadimpalli A, Theriault BR, Huang YE, Tune JD, Herring PB, Farrugia G, Kashyap PC, Antonopoulos DA, Chang EB.

Physiol Rep. 2017 Mar;5(6). pii: e13182. doi: 10.14814/phy2.13182.


Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4.

Alcaino C, Knutson K, Gottlieb PA, Farrugia G, Beyder A.

Channels (Austin). 2017 May 4;11(3):245-253. doi: 10.1080/19336950.2017.1279370. Epub 2017 Jan 13.


Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-analysis.

Klem F, Wadhwa A, Prokop LJ, Sundt WJ, Farrugia G, Camilleri M, Singh S, Grover M.

Gastroenterology. 2017 Apr;152(5):1042-1054.e1. doi: 10.1053/j.gastro.2016.12.039. Epub 2017 Jan 6. Review.


Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum.

Grover M, Bernard CE, Pasricha PJ, Parkman HP, Gibbons SJ, Tonascia J, Koch KL, McCallum RW, Sarosiek I, Hasler WL, Nguyen LAB, Abell TL, Snape WJ, Kendrick ML, Kellogg TA, McKenzie TJ, Hamilton FA, Farrugia G; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13018. Epub 2017 Jan 9.


High-resolution electrical mapping of porcine gastric slow-wave propagation from the mucosal surface.

Angeli TR, Du P, Paskaranandavadivel N, Sathar S, Hall A, Asirvatham SJ, Farrugia G, Windsor JA, Cheng LK, O'Grady G.

Neurogastroenterol Motil. 2017 May;29(5). doi: 10.1111/nmo.13010. Epub 2016 Dec 29.


Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca2+ transients and slow waves in adult mouse small intestine.

Malysz J, Gibbons SJ, Saravanaperumal SA, Du P, Eisenman ST, Cao C, Oh U, Saur D, Klein S, Ordog T, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G228-G245. doi: 10.1152/ajpgi.00363.2016. Epub 2016 Dec 15.


TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M.

Henström M, Hadizadeh F, Beyder A, Bonfiglio F, Zheng T, Assadi G, Rafter J, Bujanda L, Agreus L, Andreasson A, Dlugosz A, Lindberg G, Schmidt PT, Karling P, Ohlsson B, Talley NJ, Simren M, Walter S, Wouters M, Farrugia G, D'Amato M.

Gut. 2016 Dec 14. pii: gutjnl-2016-313346. doi: 10.1136/gutjnl-2016-313346. [Epub ahead of print] No abstract available.


Anti-Hu antibodies activate enteric and sensory neurons.

Li Q, Michel K, Annahazi A, Demir IE, Ceyhan GO, Zeller F, Komorowski L, Stöcker W, Beyak MJ, Grundy D, Farrugia G, De Giorgio R, Schemann M.

Sci Rep. 2016 Dec 1;6:38216. doi: 10.1038/srep38216.


Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice.

Choi KM, Gibbons SJ, Sha L, Beyder A, Verhulst PJ, Cipriani G, Phillips JE, Bauer AJ, Ordog T, Camp JJ, Ge X, Bharucha AE, Linden DR, Szurszewski JH, Kashyap PC, Farrugia G.

Cell Mol Gastroenterol Hepatol. 2016 Apr 23;2(4):454-467. eCollection 2016 Jul.


Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing.

Parkman HP, Hallinan EK, Hasler WL, Farrugia G, Koch KL, Nguyen L, Snape WJ, Abell TL, McCallum RW, Sarosiek I, Pasricha PJ, Clarke J, Miriel L, Tonascia J, Hamilton F; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

Neurogastroenterol Motil. 2017 Apr;29(4). doi: 10.1111/nmo.12981. Epub 2016 Oct 25.


Tumor necrosis factor alpha derived from classically activated "M1" macrophages reduces interstitial cell of Cajal numbers.

Eisenman ST, Gibbons SJ, Verhulst PJ, Cipriani G, Saur D, Farrugia G.

Neurogastroenterol Motil. 2017 Apr;29(4). doi: 10.1111/nmo.12984. Epub 2016 Oct 25.


Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis.

Bharucha AE, Daley SL, Low PA, Gibbons SJ, Choi KM, Camilleri M, Saw JJ, Farrugia G, Zinsmeister AR.

Neurogastroenterol Motil. 2016 Nov;28(11):1731-1740. doi: 10.1111/nmo.12874. Epub 2016 Jun 9.


Altered gut microbiota in female mice with persistent low body weights following removal of post-weaning chronic dietary restriction.

Chen J, Toyomasu Y, Hayashi Y, Linden DR, Szurszewski JH, Nelson H, Farrugia G, Kashyap PC, Chia N, Ordog T.

Genome Med. 2016 Oct 3;8(1):103.


Multidisciplinary model to implement pharmacogenomics at the point of care.

Caraballo PJ, Hodge LS, Bielinski SJ, Stewart AK, Farrugia G, Schultz CG, Rohrer-Vitek CR, Olson JE, St Sauver JL, Roger VL, Parkulo MA, Kullo IJ, Nicholson WT, Elliott MA, Black JL, Weinshilboum RM.

Genet Med. 2017 Apr;19(4):421-429. doi: 10.1038/gim.2016.120. Epub 2016 Sep 22.

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