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Items: 1 to 20 of 39


Osteoprotection Through the Deletion of the Transcription Factor RorĪ² in Mice.

Farr JN, Weivoda MM, Nicks KM, Fraser DG, Negley BA, Onken JL, Thicke BS, Ruan M, Liu H, Forrest D, Hawse JR, Khosla S, Monroe DG.

J Bone Miner Res. 2017 Dec 5. doi: 10.1002/jbmr.3351. [Epub ahead of print]


Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384c.


Fracture Incidence and Characteristics in Young Adults Aged 18 to 49 Years: A Population-Based Study.

Farr JN, Melton LJ 3rd, Achenbach SJ, Atkinson EJ, Khosla S, Amin S.

J Bone Miner Res. 2017 Jul 29. doi: 10.1002/jbmr.3228. [Epub ahead of print]


Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.


The Impact of Fat and Obesity on Bone Microarchitecture and Strength in Children.

Farr JN, Dimitri P.

Calcif Tissue Int. 2017 May;100(5):500-513. doi: 10.1007/s00223-016-0218-3. Epub 2016 Dec 24. Review.


Identification of Senescent Cells in the Bone Microenvironment.

Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S.

J Bone Miner Res. 2016 Nov;31(11):1920-1929. doi: 10.1002/jbmr.2892. Epub 2016 Oct 24.


Beta-Catenin Haplo Insufficient Male Mice Do Not Lose Bone in Response to Hindlimb Unloading.

Maurel DB, Duan P, Farr J, Cheng AL, Johnson ML, Bonewald LF.

PLoS One. 2016 Jul 13;11(7):e0158381. doi: 10.1371/journal.pone.0158381. eCollection 2016.


Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing.

Farr JN, Roforth MM, Fujita K, Nicks KM, Cunningham JM, Atkinson EJ, Therneau TM, McCready LK, Peterson JM, Drake MT, Monroe DG, Khosla S.

PLoS One. 2015 Sep 24;10(9):e0138347. doi: 10.1371/journal.pone.0138347. eCollection 2015.


Regarding "True Gold or Pyrite: A Review of Reference Point Indentation for Assessing Bone Mechanical Properties In Vivo".

Farr JN, Amin S, Khosla S.

J Bone Miner Res. 2015 Dec;30(12):2325-6. doi: 10.1002/jbmr.2700. Epub 2015 Sep 16. No abstract available.


Determinants of bone strength and quality in diabetes mellitus in humans.

Farr JN, Khosla S.

Bone. 2016 Jan;82:28-34. doi: 10.1016/j.bone.2015.07.027. Epub 2015 Jul 26. Review.


Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells.

McGee-Lawrence ME, Carpio LR, Schulze RJ, Pierce JL, McNiven MA, Farr JN, Khosla S, Oursler MJ, Westendorf JJ.

J Bone Miner Res. 2016 Jan;31(1):116-28. doi: 10.1002/jbmr.2602. Epub 2015 Aug 20.


Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay.

Bergen HR 3rd, Farr JN, Vanderboom PM, Atkinson EJ, White TA, Singh RJ, Khosla S, LeBrasseur NK.

Skelet Muscle. 2015 Jul 15;5:21. doi: 10.1186/s13395-015-0047-5. eCollection 2015.


Skeletal changes through the lifespan--from growth to senescence.

Farr JN, Khosla S.

Nat Rev Endocrinol. 2015 Sep;11(9):513-21. doi: 10.1038/nrendo.2015.89. Epub 2015 Jun 2. Review.


Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women.

Roforth MM, Farr JN, Fujita K, McCready LK, Atkinson EJ, Therneau TM, Cunningham JM, Drake MT, Monroe DG, Khosla S.

Bone. 2015 Jul;76:49-57. doi: 10.1016/j.bone.2015.03.017. Epub 2015 Mar 27.


The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL.

Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22.


Predictors of teriparatide treatment failure in patients with low bone mass.

Elraiyah T, Ahmed AH, Wang Z, Farr JN, Murad MH, Drake MT.

Bone Rep. 2015 Nov 17;4:17-22. doi: 10.1016/j.bonr.2015.11.001. eCollection 2016 Jun.


Exercise, hormones and skeletal adaptations during childhood and adolescence.

Farr JN, Laddu DR, Going SB.

Pediatr Exerc Sci. 2014 Nov;26(4):384-91. doi: 10.1123/pes.2014-0077. Review.


Body composition during childhood and adolescence: relations to bone strength and microstructure.

Farr JN, Amin S, LeBrasseur NK, Atkinson EJ, Achenbach SJ, McCready LK, Joseph Melton L 3rd, Khosla S.

J Clin Endocrinol Metab. 2014 Dec;99(12):4641-8. doi: 10.1210/jc.2014-1113.


Inhibitors of sclerostin: emerging concepts.

Drake MT, Farr JN.

Curr Opin Rheumatol. 2014 Jul;26(4):447-52. doi: 10.1097/BOR.0000000000000073. Review.


Diminished bone strength is observed in adult women and men who sustained a mild trauma distal forearm fracture during childhood.

Farr JN, Khosla S, Achenbach SJ, Atkinson EJ, Kirmani S, McCready LK, Melton LJ 3rd, Amin S.

J Bone Miner Res. 2014 Oct;29(10):2193-202. doi: 10.1002/jbmr.2257.

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