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Items: 1 to 20 of 193


Platelet collagen receptor gpvi-dimer recognizes fibrinogen and fibrin through their d-domains, contributing to platelet adhesion and activation during thrombus formation.

Induruwa I, Moroi M, Bonna A, Malcor JD, Howes JM, Warburton EA, Farndale RW, Jung SM.

J Thromb Haemost. 2017 Dec 5. doi: 10.1111/jth.13919. [Epub ahead of print]


Selecting the correct cellular model for assessing of the biological response of collagen-based biomaterials.

Davidenko N, Hamaia S, Bax DV, Malcor JD, Schuster CF, Gullberg D, Farndale RW, Best SM, Cameron RE.

Acta Biomater. 2018 Jan;65:88-101. doi: 10.1016/j.actbio.2017.10.035. Epub 2017 Oct 26.


Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions.

Pugh N, Maddox BD, Bihan D, Taylor KA, Mahaut-Smith MP, Farndale RW.

Thromb Haemost. 2017 Jul 26;117(8):1588-1600. doi: 10.1160/TH16-12-0906. Epub 2017 May 24.


Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin.

Paracuellos P, Kalamajski S, Bonna A, Bihan D, Farndale RW, Hohenester E.

Matrix Biol. 2017 Nov;63:106-116. doi: 10.1016/j.matbio.2017.02.002. Epub 2017 Feb 17.


Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets.

Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM.

J Thromb Haemost. 2017 Mar;15(3):549-564. doi: 10.1111/jth.13613. Epub 2017 Feb 16.


Fundamental insight into the effect of carbodiimide crosslinking on cellular recognition of collagen-based scaffolds.

Bax DV, Davidenko N, Gullberg D, Hamaia SW, Farndale RW, Best SM, Cameron RE.

Acta Biomater. 2017 Feb;49:218-234. doi: 10.1016/j.actbio.2016.11.059. Epub 2016 Nov 30.


Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry.

Davidenko N, Schuster CF, Bax DV, Farndale RW, Hamaia S, Best SM, Cameron RE.

J Mater Sci Mater Med. 2016 Oct;27(10):148. doi: 10.1007/s10856-016-5763-9. Epub 2016 Aug 31.


Unique charge-dependent constraint on collagen recognition by integrin α10β1.

Hamaia SW, Luff D, Hunter EJ, Malcor JD, Bihan D, Gullberg D, Farndale RW.

Matrix Biol. 2017 May;59:80-94. doi: 10.1016/j.matbio.2016.08.010. Epub 2016 Aug 25.


Mapping the Effect of Gly Mutations in Collagen on α2β1 Integrin Binding.

Yigit S, Yu H, An B, Hamaia S, Farndale RW, Kaplan DL, Lin YS, Brodsky B.

J Biol Chem. 2016 Sep 2;291(36):19196-207. doi: 10.1074/jbc.M116.726182. Epub 2016 Jul 18.


Intrinsic local destabilization of the C-terminus predisposes integrin α1 I domain to a conformational switch induced by collagen binding.

Nunes AM, Zhu J, Jezioro J, Minetti CA, Remeta DP, Farndale RW, Hamaia SW, Baum J.

Protein Sci. 2016 Sep;25(9):1672-81. doi: 10.1002/pro.2972. Epub 2016 Aug 1.


The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.

Parker DN, Tasneem S, Farndale RW, Bihan D, Sadler JE, Sebastian S, de Groot PG, Hayward CP.

Thromb Haemost. 2016 Jul 4;116(1):87-95. doi: 10.1160/TH15-09-0700. Epub 2016 Apr 7.


Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase.

Kalamajski S, Bihan D, Bonna A, Rubin K, Farndale RW.

J Biol Chem. 2016 Apr 8;291(15):7951-60. doi: 10.1074/jbc.M115.693408. Epub 2016 Feb 18.


The synthesis and coupling of photoreactive collagen-based peptides to restore integrin reactivity to an inert substrate, chemically-crosslinked collagen.

Malcor JD, Bax D, Hamaia SW, Davidenko N, Best SM, Cameron RE, Farndale RW, Bihan D.

Biomaterials. 2016 Apr;85:65-77. doi: 10.1016/j.biomaterials.2016.01.044. Epub 2016 Jan 23.


Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor.

An B, Abbonante V, Xu H, Gavriilidou D, Yoshizumi A, Bihan D, Farndale RW, Kaplan DL, Balduini A, Leitinger B, Brodsky B.

J Biol Chem. 2016 Feb 26;291(9):4343-55. doi: 10.1074/jbc.M115.674507. Epub 2015 Dec 23.


Optimisation of UV irradiation as a binding site conserving method for crosslinking collagen-based scaffolds.

Davidenko N, Bax DV, Schuster CF, Farndale RW, Hamaia SW, Best SM, Cameron RE.

J Mater Sci Mater Med. 2016 Jan;27(1):14. doi: 10.1007/s10856-015-5627-8. Epub 2015 Dec 16.


The Concise Guide to PHARMACOLOGY 2015/16: Overview.

Alexander SP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA; CGTP Collaborators.

Br J Pharmacol. 2015 Dec;172(24):5729-43. doi: 10.1111/bph.13347.


Structural basis for collagen recognition by the immune receptor OSCAR.

Zhou L, Hinerman JM, Blaszczyk M, Miller JL, Conrady DG, Barrow AD, Chirgadze DY, Bihan D, Farndale RW, Herr AB.

Blood. 2016 Feb 4;127(5):529-37. doi: 10.1182/blood-2015-08-667055. Epub 2015 Nov 9.


Modified platelet deposition on matrix metalloproteinase 13 digested collagen I.

Howes JM, Pugh N, Knäuper V, Farndale RW.

J Thromb Haemost. 2015 Dec;13(12):2253-9. doi: 10.1111/jth.13166. Epub 2015 Nov 30.


Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner.

Watson BR, White NA, Taylor KA, Howes JM, Malcor JD, Bihan D, Sage SO, Farndale RW, Pugh N.

Metallomics. 2016 Jan;8(1):91-100. doi: 10.1039/c5mt00064e.


Hydroxyproline Ring Pucker Causes Frustration of Helix Parameters in the Collagen Triple Helix.

Chow WY, Bihan D, Forman CJ, Slatter DA, Reid DG, Wales DJ, Farndale RW, Duer MJ.

Sci Rep. 2015 Jul 29;5:12556. doi: 10.1038/srep12556.

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