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Items: 11


Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.

Dattaroy D, Seth RK, Sarkar S, Kimono D, Albadrani M, Chandrashekaran V, Hasson FA, Singh UP, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S.

Eur J Pharmacol. 2018 Sep 5;841:33-48. doi: 10.1016/j.ejphar.2018.08.040. [Epub ahead of print]


Correction: Sparstolonin B, a Novel Plant Derived Compound, Arrests Cell Cycle and Induces Apoptosis in N-Myc Amplified and N-Myc Nonamplified Neuroblastoma Cells.

Kumar A, Fan D, DiPette DJ, Singh US.

PLoS One. 2016 Jul 6;11(7):e0159082. doi: 10.1371/journal.pone.0159082. eCollection 2016.


Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation.

Dattaroy D, Seth RK, Das S, Alhasson F, Chandrashekaran V, Michelotti G, Fan D, Nagarkatti M, Nagarkatti P, Diehl AM, Chatterjee S.

Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1;310(7):G510-25. doi: 10.1152/ajpgi.00259.2015. Epub 2015 Dec 30.


Sparstolonin B suppresses rat vascular smooth muscle cell proliferation, migration, inflammatory response and lipid accumulation.

Liu Q, Li J, Liang Q, Wang D, Luo Y, Yu F, Janicki JS, Fan D.

Vascul Pharmacol. 2015 Apr-Jun;67-69:59-66. doi: 10.1016/j.vph.2015.03.015. Epub 2015 Apr 11.


Protective effects of Sparstolonin B, a selective TLR2 and TLR4 antagonist, on mouse endotoxin shock.

Liang Q, Dong S, Lei L, Liu J, Zhang J, Li J, Duan J, Fan D.

Cytokine. 2015 Oct;75(2):302-9. doi: 10.1016/j.cyto.2014.12.003. Epub 2015 Jan 5.


Sparstolonin B attenuates hypoxia-induced apoptosis, necrosis and inflammation in cultured rat left ventricular tissue slices.

Liu Q, Li J, Jubair S, Wang D, Luo Y, Fan D, Janicki JS.

Cardiovasc Drugs Ther. 2014 Oct;28(5):433-9. doi: 10.1007/s10557-014-6545-6.


Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells.

Kumar A, Fan D, Dipette DJ, Singh US.

PLoS One. 2014 May 1;9(5):e96343. doi: 10.1371/journal.pone.0096343. eCollection 2014. Erratum in: PLoS One. 2016;11(7):e0159082.


Sparstolonin B attenuates hypoxia-reoxygenation-induced cardiomyocyte inflammation.

Liu Q, Wang J, Liang Q, Wang D, Luo Y, Li J, Janicki JS, Fan D.

Exp Biol Med (Maywood). 2014 Mar;239(3):376-84. doi: 10.1177/1535370213517620. Epub 2014 Jan 29.


Sparstolonin B inhibits pro-angiogenic functions and blocks cell cycle progression in endothelial cells.

Bateman HR, Liang Q, Fan D, Rodriguez V, Lessner SM.

PLoS One. 2013 Aug 5;8(8):e70500. doi: 10.1371/journal.pone.0070500. Print 2013.


Sparstolonin B suppresses lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells.

Liang Q, Yu F, Cui X, Duan J, Wu Q, Nagarkatti P, Fan D.

Arch Pharm Res. 2013 Jul;36(7):890-6. doi: 10.1007/s12272-013-0120-8. Epub 2013 Apr 20.


Characterization of sparstolonin B, a Chinese herb-derived compound, as a selective Toll-like receptor antagonist with potent anti-inflammatory properties.

Liang Q, Wu Q, Jiang J, Duan J, Wang C, Smith MD, Lu H, Wang Q, Nagarkatti P, Fan D.

J Biol Chem. 2011 Jul 29;286(30):26470-9. doi: 10.1074/jbc.M111.227934. Epub 2011 Jun 10.

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