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Items: 1 to 20 of 59

1.

ALX receptor ligands define a biochemical endotype for severe asthma.

Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators.

JCI Insight. 2017 Jul 20;2(14). pii: 93534. doi: 10.1172/jci.insight.93534. [Epub ahead of print]

2.

Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.

Lachowicz-Scroggins ME, Yuan S, Kerr SC, Dunican EM, Yu M, Carrington SD, Fahy JV.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1296-1299. No abstract available.

3.

IL1RL1 asthma risk variants regulate airway type 2 inflammation.

Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA.

JCI Insight. 2016 Sep 8;1(14):e87871.

4.

Alternative splicing of interleukin-33 and type 2 inflammation in asthma.

Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8765-70. doi: 10.1073/pnas.1601914113. Epub 2016 Jul 18.

5.

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts.

Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV; National Heart, Lung, and Blood Institute Severe Asthma Research Program.

Lancet Respir Med. 2016 Jul;4(7):574-84. doi: 10.1016/S2213-2600(16)30048-0. Epub 2016 Jun 6.

6.

Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25.

Gordon ED, Locksley RM, Fahy JV.

Am J Respir Crit Care Med. 2016 May 1;193(9):935-6. doi: 10.1164/rccm.201512-2534ED. No abstract available.

7.

FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection.

Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV.

PLoS Pathog. 2016 Apr 8;12(4):e1005555. doi: 10.1371/journal.ppat.1005555. eCollection 2016 Apr.

8.

Asthma Was Talking, But We Weren't Listening. Missed or Ignored Signals That Have Slowed Treatment Progress.

Fahy JV.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S78-82. doi: 10.1513/AnnalsATS.201508-515MG. Review.

9.

The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations.

Dunican EM, Fahy JV.

Ann Am Thorac Soc. 2015 Nov;12 Suppl 2:S144-9. doi: 10.1513/AnnalsATS.201506-377AW. Review.

10.

Future Research Directions in Asthma. An NHLBI Working Group Report.

Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA Jr, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC.

Am J Respir Crit Care Med. 2015 Dec 1;192(11):1366-72. doi: 10.1164/rccm.201505-0963WS. Review.

11.

Oxidation increases mucin polymer cross-links to stiffen airway mucus gels.

Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM, Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S, Fahy JV.

Sci Transl Med. 2015 Feb 25;7(276):276ra27. doi: 10.1126/scitranslmed.3010525.

12.

Type 2 inflammation in asthma--present in most, absent in many.

Fahy JV.

Nat Rev Immunol. 2015 Jan;15(1):57-65. doi: 10.1038/nri3786. Review.

13.

A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.

Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM.

Nat Immunol. 2014 Dec;15(12):1162-70. doi: 10.1038/ni.3026. Epub 2014 Nov 2.

14.

Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.

Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS.

PLoS One. 2014 Jun 10;9(6):e99084. doi: 10.1371/journal.pone.0099084. eCollection 2014.

15.

Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases.

Jackson DJ, Hartert TV, Martinez FD, Weiss ST, Fahy JV.

Ann Am Thorac Soc. 2014 Apr;11 Suppl 3:S139-45. doi: 10.1513/AnnalsATS.201312-448LD. Review.

16.

Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma.

Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV.

Am J Respir Crit Care Med. 2014 Apr 15;189(8):1005-7. doi: 10.1164/rccm.201312-2220LE. No abstract available.

17.

Asthma and the flu: a tricky two-step.

Locksley RM, Fahy JV.

Immunol Cell Biol. 2014 May-Jun;92(5):389-91. doi: 10.1038/icb.2014.24. Epub 2014 Apr 1. No abstract available.

18.

A soluble fucose-specific lectin from Aspergillus fumigatus conidia--structure, specificity and possible role in fungal pathogenicity.

Houser J, Komarek J, Kostlanova N, Cioci G, Varrot A, Kerr SC, Lahmann M, Balloy V, Fahy JV, Chignard M, Imberty A, Wimmerova M.

PLoS One. 2013 Dec 10;8(12):e83077. doi: 10.1371/journal.pone.0083077. eCollection 2013.

19.

Chair's summary: Mechanisms of relevance to clinical heterogeneity of asthma and chronic obstructive pulmonary disease.

Fahy JV.

Ann Am Thorac Soc. 2013 Dec;10 Suppl:S108. doi: 10.1513/AnnalsATS.201307-239AW. No abstract available.

20.

Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.

Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV.

J Allergy Clin Immunol. 2014 Feb;133(2):388-94. doi: 10.1016/j.jaci.2013.07.036. Epub 2013 Sep 24.

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