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Characterization of an RNase with two catalytic centers. Human RNase6 catalytic and phosphate-binding site arrangement favors the endonuclease cleavage of polymeric substrates.

Prats-Ejarque G, Blanco JA, Salazar VA, Nogués VM, Moussaoui M, Boix E.

Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):105-117. doi: 10.1016/j.bbagen.2018.09.021. Epub 2018 Oct 1.


Unveiling the Multifaceted Mechanisms of Antibacterial Activity of Buforin II and Frenatin 2.3S Peptides from Skin Micro-Organs of the Orinoco Lime Treefrog (Sphaenorhynchus lacteus).

Muñoz-Camargo C, Salazar VA, Barrero-Guevara L, Camargo S, Mosquera A, Groot H, Boix E.

Int J Mol Sci. 2018 Jul 25;19(8). pii: E2170. doi: 10.3390/ijms19082170.


Immune Modulation by Human Secreted RNases at the Extracellular Space.

Lu L, Li J, Moussaoui M, Boix E.

Front Immunol. 2018 May 16;9:1012. doi: 10.3389/fimmu.2018.01012. eCollection 2018. Review.


Positional scanning library applied to the human eosinophil cationic protein/RNase3 N-terminus reveals novel and potent anti-biofilm peptides.

Pulido D, Prats-Ejarque G, Villalba C, Albacar M, Moussaoui M, Andreu D, Volkmer R, Torrent M, Boix E.

Eur J Med Chem. 2018 May 25;152:590-599. doi: 10.1016/j.ejmech.2018.05.012. Epub 2018 May 8.


Structural similarities in the CPC clip motif explain peptide-binding promiscuity between glycosaminoglycans and lipopolysaccharides.

Pulido D, Rebollido-Rios R, Valle J, Andreu D, Boix E, Torrent M.

J R Soc Interface. 2017 Nov;14(136). pii: 20170423. doi: 10.1098/rsif.2017.0423.


Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis.

Arranz-Trullén J, Lu L, Pulido D, Bhakta S, Boix E.

Front Immunol. 2017 Nov 7;8:1499. doi: 10.3389/fimmu.2017.01499. eCollection 2017. Review.


Structural basis for endotoxin neutralization by the eosinophil cationic protein.

Pulido D, Garcia-Mayoral MF, Moussaoui M, Velázquez D, Torrent M, Bruix M, Boix E.

FEBS J. 2016 Nov;283(22):4176-4191. doi: 10.1111/febs.13915. Epub 2016 Oct 31.


A Novel RNase 3/ECP Peptide for Pseudomonas aeruginosa Biofilm Eradication That Combines Antimicrobial, Lipopolysaccharide Binding, and Cell-Agglutinating Activities.

Pulido D, Prats-Ejarque G, Villalba C, Albacar M, González-López JJ, Torrent M, Moussaoui M, Boix E.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6313-25. doi: 10.1128/AAC.00830-16. Print 2016 Oct.


Exploring the mechanisms of action of human secretory RNase 3 and RNase 7 against Candida albicans.

Salazar VA, Arranz-Trullén J, Navarro S, Blanco JA, Sánchez D, Moussaoui M, Boix E.

Microbiologyopen. 2016 Oct;5(5):830-845. doi: 10.1002/mbo3.373. Epub 2016 Jun 8.


Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation.

Pulido D, Arranz-Trullén J, Prats-Ejarque G, Velázquez D, Torrent M, Moussaoui M, Boix E.

Int J Mol Sci. 2016 Apr 13;17(4):552. doi: 10.3390/ijms17040552.


The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement.

Prats-Ejarque G, Arranz-Trullén J, Blanco JA, Pulido D, Nogués MV, Moussaoui M, Boix E.

Biochem J. 2016 Jun 1;473(11):1523-36. doi: 10.1042/BCJ20160245. Epub 2016 Mar 24.


Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin.

Chatzileontiadou DS, Parmenopoulou V, Manta S, Kantsadi AL, Kylindri P, Griniezaki M, Kontopoulou F, Telopoulou A, Prokova H, Panagopoulos D, Boix E, Balatsos NA, Komiotis D, Leonidas DD.

Bioorg Chem. 2015 Dec;63:152-65. doi: 10.1016/j.bioorg.2015.10.007. Epub 2015 Oct 31.


Protein post-translational modification in host defense: the antimicrobial mechanism of action of human eosinophil cationic protein native forms.

Salazar VA, Rubin J, Moussaoui M, Pulido D, Nogués MV, Venge P, Boix E.

FEBS J. 2014 Dec;281(24):5432-46. doi: 10.1111/febs.13082. Epub 2014 Oct 20.


Towards the rational design of antimicrobial proteins: single point mutations can switch on bactericidal and agglutinating activities on the RNase A superfamily lineage.

Pulido D, Moussaoui M, Nogués MV, Torrent M, Boix E.

FEBS J. 2013 Nov;280(22):5841-52. doi: 10.1111/febs.12506. Epub 2013 Oct 8.


Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus.

Torrent M, Pulido D, Valle J, Nogués MV, Andreu D, Boix E.

Biochem J. 2013 Nov 15;456(1):99-108. doi: 10.1042/BJ20130123.


Two human host defense ribonucleases against mycobacteria, the eosinophil cationic protein (RNase 3) and RNase 7.

Pulido D, Torrent M, Andreu D, Nogués MV, Boix E.

Antimicrob Agents Chemother. 2013 Aug;57(8):3797-805. doi: 10.1128/AAC.00428-13. Epub 2013 May 28.


Nucleotide binding architecture for secreted cytotoxic endoribonucleases.

Boix E, Blanco JA, Nogués MV, Moussaoui M.

Biochimie. 2013 Jun;95(6):1087-97. doi: 10.1016/j.biochi.2012.12.015. Epub 2012 Dec 26. Review.


Exploring new biological functions of amyloids: bacteria cell agglutination mediated by host protein aggregation.

Torrent M, Pulido D, Nogués MV, Boix E.

PLoS Pathog. 2012;8(11):e1003005. doi: 10.1371/journal.ppat.1003005. Epub 2012 Nov 1.


Insights into the glycosaminoglycan-mediated cytotoxic mechanism of eosinophil cationic protein revealed by NMR.

García-Mayoral MF, Canales A, Díaz D, López-Prados J, Moussaoui M, de Paz JL, Angulo J, Nieto PM, Jiménez-Barbero J, Boix E, Bruix M.

ACS Chem Biol. 2013 Jan 18;8(1):144-51. doi: 10.1021/cb300386v. Epub 2012 Oct 9.


Structural determinants of the eosinophil cationic protein antimicrobial activity.

Boix E, Salazar VA, Torrent M, Pulido D, Nogués MV, Moussaoui M.

Biol Chem. 2012 Aug;393(8):801-15. doi: 10.1515/hsz-2012-0160. Review.


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