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Items: 1 to 20 of 122

1.

Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation.

Sengyee S, Yoon SH, Paksanont S, Yimthin T, Wuthiekanun V, Limmathurotsakul D, West TE, Ernst RK, Chantratita N.

PLoS Negl Trop Dis. 2018 Feb 23;12(2):e0006287. doi: 10.1371/journal.pntd.0006287. eCollection 2018 Feb.

2.

Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate.

Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour DPA, Ernst RK, Cross AS, Goodlett DR.

J Am Soc Mass Spectrom. 2018 Feb 20. doi: 10.1007/s13361-018-1897-y. [Epub ahead of print]

PMID:
29464544
3.

CXC Chemokines Exhibit Bactericidal Activity against Multidrug-Resistant Gram-Negative Pathogens.

Crawford MA, Fisher DJ, Leung LM, Lomonaco S, Lascols C, Cannatelli A, Giani T, Rossolini GM, Doi Y, Goodlett DR, Allard MW, Sharma SK, Khan E, Ernst RK, Hughes MA.

MBio. 2017 Nov 14;8(6). pii: e01549-17. doi: 10.1128/mBio.01549-17.

4.

Host-based lipid inflammation drives pathogenesis in Francisella infection.

Scott AJ, Post JM, Lerner R, Ellis SR, Lieberman J, Shirey KA, Heeren RMA, Bindila L, Ernst RK.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12596-12601. doi: 10.1073/pnas.1712887114. Epub 2017 Nov 6.

PMID:
29109289
5.

Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness.

Hajjar AM, Ernst RK, Yi J, Yam CS, Miller SI.

PLoS One. 2017 Oct 11;12(10):e0186308. doi: 10.1371/journal.pone.0186308. eCollection 2017.

6.

Probing the sRNA regulatory landscape of P. aeruginosa: post-transcriptional control of determinants of pathogenicity and antibiotic susceptibility.

Zhang YF, Han K, Chandler CE, Tjaden B, Ernst RK, Lory S.

Mol Microbiol. 2017 Dec;106(6):919-937. doi: 10.1111/mmi.13857. Epub 2017 Nov 2.

PMID:
28976035
7.

Structural modification of LPS in colistin-resistant, KPC-producing Klebsiella pneumoniae.

Leung LM, Cooper VS, Rasko DA, Guo Q, Pacey MP, McElheny CL, Mettus RT, Yoon SH, Goodlett DR, Ernst RK, Doi Y.

J Antimicrob Chemother. 2017 Nov 1;72(11):3035-3042. doi: 10.1093/jac/dkx234.

PMID:
28961916
8.

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria.

Barker WT, Martin SE, Chandler CE, Nguyen TV, Harris TL, Goodell C, Melander RJ, Doi Y, Ernst RK, Melander C.

Bioorg Med Chem. 2017 Oct 15;25(20):5749-5753. doi: 10.1016/j.bmc.2017.08.055. Epub 2017 Sep 9.

PMID:
28958847
9.

Structural basis of MsbA-mediated lipopolysaccharide transport.

Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M.

Nature. 2017 Sep 14;549(7671):233-237. doi: 10.1038/nature23649. Epub 2017 Sep 6.

10.

Bacterial lipids: powerful modifiers of the innate immune response.

Chandler CE, Ernst RK.

F1000Res. 2017 Aug 7;6. pii: F1000 Faculty Rev-1334. doi: 10.12688/f1000research.11388.1. eCollection 2017. Review.

11.

Mass spectrometry analysis of intact Francisella bacteria identifies lipid A structure remodeling in response to acidic pH stress.

Robert CB, Thomson M, Vercellone A, Gardner F, Ernst RK, Larrouy-Maumus G, Nigou J.

Biochimie. 2017 Oct;141:16-20. doi: 10.1016/j.biochi.2017.08.008. Epub 2017 Aug 12.

PMID:
28807561
12.

Identification of the ESKAPE pathogens by mass spectrometric analysis of microbial membrane glycolipids.

Leung LM, Fondrie WE, Doi Y, Johnson JK, Strickland DK, Ernst RK, Goodlett DR.

Sci Rep. 2017 Jul 25;7(1):6403. doi: 10.1038/s41598-017-04793-4.

13.

Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery.

Gregg KA, Harberts E, Gardner FM, Pelletier MR, Cayatte C, Yu L, McCarthy MP, Marshall JD, Ernst RK.

MBio. 2017 May 9;8(3). pii: e00492-17. doi: 10.1128/mBio.00492-17.

14.

Structural Modification of Lipopolysaccharide Conferred by mcr-1 in Gram-Negative ESKAPE Pathogens.

Liu YY, Chandler CE, Leung LM, McElheny CL, Mettus RT, Shanks RMQ, Liu JH, Goodlett DR, Ernst RK, Doi Y.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00580-17. doi: 10.1128/AAC.00580-17. Print 2017 Jun.

15.

Infection-derived lipids elicit an immune deficiency circuit in arthropods.

Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH.

Nat Commun. 2017 Feb 14;8:14401. doi: 10.1038/ncomms14401.

16.

Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship.

Scott AJ, Oyler BL, Goodlett DR, Ernst RK.

Biochim Biophys Acta. 2017 Nov;1862(11):1439-1450. doi: 10.1016/j.bbalip.2017.01.004. Epub 2017 Jan 17. Review.

PMID:
28108356
17.

Monophosphoryl Lipid A Enhances Efficacy of a Francisella tularensis LVS-Catanionic Nanoparticle Subunit Vaccine against F. tularensis Schu S4 Challenge by Augmenting both Humoral and Cellular Immunity.

Richard K, Mann BJ, Qin A, Barry EM, Ernst RK, Vogel SN.

Clin Vaccine Immunol. 2017 Mar 6;24(3). pii: e00574-16. doi: 10.1128/CVI.00574-16. Print 2017 Mar.

18.

In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress.

Jones CL, Singh SS, Alamneh Y, Casella LG, Ernst RK, Lesho EP, Waterman PE, Zurawski DV.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e00598-16. doi: 10.1128/AAC.00598-16. Print 2017 Mar.

19.

Global Analysis and Comparison of the Transcriptomes and Proteomes of Group A Streptococcus Biofilms.

Freiberg JA, Le Breton Y, Tran BQ, Scott AJ, Harro JM, Ernst RK, Goo YA, Mongodin EF, Goodlett DR, McIver KS, Shirtliff ME.

mSystems. 2016 Dec 6;1(6). pii: e00149-16. eCollection 2016 Nov-Dec.

20.

Autopiquer - a Robust and Reliable Peak Detection Algorithm for Mass Spectrometry.

Kilgour DPA, Hughes S, Kilgour SL, Mackay CL, Palmblad M, Tran BQ, Goo YA, Ernst RK, Clarke DJ, Goodlett DR.

J Am Soc Mass Spectrom. 2017 Feb;28(2):253-262. doi: 10.1007/s13361-016-1549-z. Epub 2016 Dec 6.

PMID:
27924495

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