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Items: 1 to 20 of 226

1.

Synthesis of [5,6]-Bicyclic Heterocycles with a Ring-Junction Nitrogen via Rh(III)-Catalyzed C-H Functionalization of Alkenyl Azoles.

Ellman JA, Halksov K, Roth H.

Angew Chem Int Ed Engl. 2017 Jun 6. doi: 10.1002/anie.201703967. [Epub ahead of print]

PMID:
28586164
2.

Total Synthesis of (+)-Pancratistatin by the Rh(III)-Catalyzed Addition of a Densely Functionalized Benzamide to a Sugar-Derived Nitroalkene.

Potter TJ, Ellman JA.

Org Lett. 2017 Jun 2;19(11):2985-2988. doi: 10.1021/acs.orglett.7b01220. Epub 2017 May 24.

PMID:
28537406
3.

Rh(III)-Catalyzed Aryl and Alkenyl C-H Bond Addition to Diverse Nitroalkenes.

Potter TJ, Kamber DN, Mercado BQ, Ellman JA.

ACS Catal. 2017 Jan 6;7(1):150-153. doi: 10.1021/acscatal.6b03217. Epub 2016 Dec 2.

PMID:
28435749
4.

Base-Controlled Completely Selective Linear or Branched Rhodium(I)-Catalyzed C-H ortho-Alkylation of Azines without Preactivation.

Tran G, Hesp KD, Mascitti V, Ellman JA.

Angew Chem Int Ed Engl. 2017 May 15;56(21):5899-5903. doi: 10.1002/anie.201702409. Epub 2017 Apr 21.

PMID:
28429455
5.

Transition-Metal-Catalyzed C-H Bond Addition to Carbonyls, Imines, and Related Polarized π Bonds.

Hummel JR, Boerth JA, Ellman JA.

Chem Rev. 2016 Dec 12. [Epub ahead of print]

PMID:
27936637
6.

Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.

Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ.

Mol Psychiatry. 2016 Oct 18. doi: 10.1038/mp.2016.163. [Epub ahead of print]

7.

Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors.

Jamali H, Khan HA, Tjin CC, Ellman JA.

ACS Med Chem Lett. 2016 Jul 20;7(9):847-51. doi: 10.1021/acsmedchemlett.6b00215. eCollection 2016 Sep 8.

PMID:
27660689
8.

New Regio- and Stereoselective Cascades via Unstabilized Azomethine Ylide Cycloadditions for the Synthesis of Highly Substituted Tropane and Indolizidine Frameworks.

Chen S, Bacauanu V, Knecht T, Mercado BQ, Bergman RG, Ellman JA.

J Am Chem Soc. 2016 Sep 28;138(38):12664-70. doi: 10.1021/jacs.6b08355. Epub 2016 Sep 19.

PMID:
27642766
9.

Conjugate addition-enantioselective protonation reactions.

Phelan JP, Ellman JA.

Beilstein J Org Chem. 2016 Jun 15;12:1203-28. doi: 10.3762/bjoc.12.116. eCollection 2016. Review.

10.

Rh(III)-Catalyzed C-H Bond Addition/Amine-Mediated Cyclization of Bis-Michael Acceptors.

Potter TJ, Ellman JA.

Org Lett. 2016 Aug 5;18(15):3838-41. doi: 10.1021/acs.orglett.6b01846. Epub 2016 Jul 20.

PMID:
27437933
11.

Convergent Synthesis of Diverse Nitrogen Heterocycles via Rh(III)-Catalyzed C-H Conjugate Addition/Cyclization Reactions.

Weinstein AB, Ellman JA.

Org Lett. 2016 Jul 1;18(13):3294-7. doi: 10.1021/acs.orglett.6b01611. Epub 2016 Jun 23.

PMID:
27337641
12.

Highly Stereoselective Cobalt(III)-Catalyzed Three-Component C-H Bond Addition Cascade.

Boerth JA, Hummel JR, Ellman JA.

Angew Chem Int Ed Engl. 2016 Oct 4;55(41):12650-4. doi: 10.1002/anie.201603831. Epub 2016 Jun 15.

PMID:
27305062
13.

Rh(III)-Catalyzed Diastereoselective C-H Bond Addition/Cyclization Cascade of Enone Tethered Aldehydes.

Boerth JA, Ellman JA.

Chem Sci. 2016 Feb 1;7(2):1474-1479. Epub 2015 Dec 1.

14.

Preparation of Enantiomerically Pure Perfluorobutanesulfinamide and Its Application to the Asymmetric Synthesis of α-Amino Acids.

Wangweerawong A, Hummel JR, Bergman RG, Ellman JA.

J Org Chem. 2016 Feb 19;81(4):1547-57. doi: 10.1021/acs.joc.5b02700. Epub 2016 Feb 4.

15.

Rh(I)-Catalyzed Cycloisomerization of 1,6-Enynes.

Matsushima Y, Phillips EM, Bergman RG, Ellman JA.

Synlett. 2015 Jul 1;26(11):1533-1536. Epub 2015 Feb 27.

16.

Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.

Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ.

Cell Mol Life Sci. 2016 Apr;73(7):1503-14. doi: 10.1007/s00018-015-2057-1. Epub 2015 Oct 8.

17.

Synthesis of ent-ketorfanol via a C-H alkenylation/torquoselective 6π electrocyclization cascade.

Phillips EM, Mesganaw T, Patel A, Duttwyler S, Mercado BQ, Houk KN, Ellman JA.

Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12044-8. doi: 10.1002/anie.201505604. Epub 2015 Aug 17.

18.

Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.

Xu J, Kurup P, Azkona G, Baguley TD, Saavedra A, Nairn AC, Ellman JA, Pérez-Navarro E, Lombroso PJ.

J Neurochem. 2016 Jan;136(2):285-94. doi: 10.1111/jnc.13295. Epub 2015 Sep 17.

19.

Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition.

Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E.

Pain. 2016 Feb;157(2):377-86. doi: 10.1097/j.pain.0000000000000329.

20.

Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease.

Neitz RJ, Bryant C, Chen S, Gut J, Caselli EH, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4834-7. doi: 10.1016/j.bmcl.2015.06.066. Epub 2015 Jun 23.

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