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Items: 1 to 20 of 48

1.

Characterization of noncoding regulatory DNA in the human genome.

Elkon R, Agami R.

Nat Biotechnol. 2017 Aug 8;35(8):732-746. doi: 10.1038/nbt.3863. Review.

PMID:
28787426
2.

Proteomic analysis of polyribosomes identifies splicing factors as potential regulators of translation during mitosis.

Aviner R, Hofmann S, Elman T, Shenoy A, Geiger T, Elkon R, Ehrlich M, Elroy-Stein O.

Nucleic Acids Res. 2017 Jun 2;45(10):5945-5957. doi: 10.1093/nar/gkx326.

3.

Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.

Slobodin B, Han R, Calderone V, Vrielink JA, Loayza-Puch F, Elkon R, Agami R.

Cell. 2017 Apr 6;169(2):326-337.e12. doi: 10.1016/j.cell.2017.03.031.

4.

Gfi1Cre mice have early onset progressive hearing loss and induce recombination in numerous inner ear non-hair cells.

Matern M, Vijayakumar S, Margulies Z, Milon B, Song Y, Elkon R, Zhang X, Jones SM, Hertzano R.

Sci Rep. 2017 Feb 9;7:42079. doi: 10.1038/srep42079.

5.

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.

Drost R, Dhillon KK, van der Gulden H, van der Heijden I, Brandsma I, Cruz C, Chondronasiou D, Castroviejo-Bermejo M, Boon U, Schut E, van der Burg E, Wientjens E, Pieterse M, Klijn C, Klarenbeek S, Loayza-Puch F, Elkon R, van Deemter L, Rottenberg S, van de Ven M, Dekkers DH, Demmers JA, van Gent DC, Agami R, Balmaña J, Serra V, Taniguchi T, Bouwman P, Jonkers J.

J Clin Invest. 2016 Aug 1;126(8):2903-18. doi: 10.1172/JCI70196. Epub 2016 Jul 25.

6.

3'UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells.

Hoffman Y, Bublik DR, Ugalde AP, Elkon R, Biniashvili T, Agami R, Oren M, Pilpel Y.

PLoS Genet. 2016 Feb 23;12(2):e1005879. doi: 10.1371/journal.pgen.1005879. eCollection 2016 Feb. Erratum in: PLoS Genet. 2016 Aug;12(8):e1006254.

7.

Redifferentiation of expanded human islet β cells by inhibition of ARX.

Friedman-Mazursky O, Elkon R, Efrat S.

Sci Rep. 2016 Feb 9;6:20698. doi: 10.1038/srep20698.

8.

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

Korkmaz G, Lopes R, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R.

Nat Biotechnol. 2016 Feb;34(2):192-8. doi: 10.1038/nbt.3450. Epub 2016 Jan 11.

PMID:
26751173
9.

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart.

Creemers EE, Bawazeer A, Ugalde AP, van Deutekom HW, van der Made I, de Groot NE, Adriaens ME, Cook SA, Bezzina CR, Hubner N, van der Velden J, Elkon R, Agami R, Pinto YM.

Circ Res. 2016 Feb 5;118(3):433-8. doi: 10.1161/CIRCRESAHA.115.307082. Epub 2015 Dec 15. Erratum in: Circ Res. 2016 Oct 14;119(9):e139.

10.

Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.

Elkon R, Loayza-Puch F, Korkmaz G, Lopes R, van Breugel PC, Bleijerveld OB, Altelaar AF, Wolf E, Lorenzin F, Eilers M, Agami R.

EMBO Rep. 2015 Dec;16(12):1723-36. doi: 10.15252/embr.201540717. Epub 2015 Nov 4.

11.

RFX transcription factors are essential for hearing in mice.

Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R.

Nat Commun. 2015 Oct 15;6:8549. doi: 10.1038/ncomms9549.

12.

Parallel profiling of the transcriptome, cistrome, and epigenome in the cellular response to ionizing radiation.

Rashi-Elkeles S, Warnatz HJ, Elkon R, Kupershtein A, Chobod Y, Paz A, Amstislavskiy V, Sultan M, Safer H, Nietfeld W, Lehrach H, Shamir R, Yaspo ML, Shiloh Y.

Sci Signal. 2014 May 13;7(325):rs3. doi: 10.1126/scisignal.2005032.

PMID:
24825921
13.

Alternative cleavage and polyadenylation: extent, regulation and function.

Elkon R, Ugalde AP, Agami R.

Nat Rev Genet. 2013 Jul;14(7):496-506. doi: 10.1038/nrg3482. Review.

PMID:
23774734
14.

p53 induces transcriptional and translational programs to suppress cell proliferation and growth.

Loayza-Puch F, Drost J, Rooijers K, Lopes R, Elkon R, Agami R.

Genome Biol. 2013 Apr 17;14(4):R32. doi: 10.1186/gb-2013-14-4-r32.

15.

eRNAs are required for p53-dependent enhancer activity and gene transcription.

Melo CA, Drost J, Wijchers PJ, van de Werken H, de Wit E, Oude Vrielink JA, Elkon R, Melo SA, Léveillé N, Kalluri R, de Laat W, Agami R.

Mol Cell. 2013 Feb 7;49(3):524-35. doi: 10.1016/j.molcel.2012.11.021. Epub 2012 Dec 27.

16.

Alternative cleavage and polyadenylation during colorectal cancer development.

Morris AR, Bos A, Diosdado B, Rooijers K, Elkon R, Bolijn AS, Carvalho B, Meijer GA, Agami R.

Clin Cancer Res. 2012 Oct 1;18(19):5256-66. doi: 10.1158/1078-0432.CCR-12-0543. Epub 2012 Aug 8.

17.

E2F mediates enhanced alternative polyadenylation in proliferation.

Elkon R, Drost J, van Haaften G, Jenal M, Schrier M, Oude Vrielink JA, Agami R.

Genome Biol. 2012 Jul 2;13(7):R59. doi: 10.1186/gb-2012-13-7-r59.

18.

High throughput gene expression analysis of the inner ear.

Hertzano R, Elkon R.

Hear Res. 2012 Jun;288(1-2):77-88. doi: 10.1016/j.heares.2012.01.002. Epub 2012 Feb 8.

PMID:
22710153
19.

The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.

Jenal M, Elkon R, Loayza-Puch F, van Haaften G, Kühn U, Menzies FM, Oude Vrielink JA, Bos AJ, Drost J, Rooijers K, Rubinsztein DC, Agami R.

Cell. 2012 Apr 27;149(3):538-53. doi: 10.1016/j.cell.2012.03.022. Epub 2012 Apr 12.

20.

Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity.

Léveillé N, Elkon R, Davalos V, Manoharan V, Hollingworth D, Oude Vrielink J, le Sage C, Melo CA, Horlings HM, Wesseling J, Ule J, Esteller M, Ramos A, Agami R.

Nat Commun. 2011 Oct 25;2:513. doi: 10.1038/ncomms1519.

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