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Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer.

Vorvis C, Hatziapostolou M, Mahurkar-Joshi S, Koutsioumpa M, Williams J, Donahue TR, Poultsides GA, Eibl G, Iliopoulos D.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1124-37. doi: 10.1152/ajpgi.00035.2016. Epub 2016 May 5.


Long-term survival in patients with pancreatic ductal adenocarcinoma.

Stark AP, Sacks GD, Rochefort MM, Donahue TR, Reber HA, Tomlinson JS, Dawson DW, Eibl G, Hines OJ.

Surgery. 2016 Jun;159(6):1520-7. doi: 10.1016/j.surg.2015.12.024. Epub 2016 Feb 2.


Phosphatidylinositol 3-Kinase: A Link Between Inflammation and Pancreatic Cancer.

Birtolo C, Go VL, Ptasznik A, Eibl G, Pandol SJ.

Pancreas. 2016 Jan;45(1):21-31. doi: 10.1097/MPA.0000000000000531. Review.


Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer.

Hertzer KM, Xu M, Moro A, Dawson DW, Du L, Li G, Chang HH, Stark AP, Jung X, Hines OJ, Eibl G.

Pancreas. 2016 Mar;45(3):458-65. doi: 10.1097/MPA.0000000000000497.


Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA- and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1.

Chang HH, Young SH, Sinnett-Smith J, Chou CE, Moro A, Hertzer KM, Hines OJ, Rozengurt E, Eibl G.

Am J Physiol Cell Physiol. 2015 Nov 15;309(10):C639-49. doi: 10.1152/ajpcell.00417.2014. Epub 2015 Aug 26.


E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice.

Stark AP, Chang HH, Jung X, Moro A, Hertzer K, Xu M, Schmidt A, Hines OJ, Eibl G.

Surgery. 2015 Dec;158(6):1564-72. doi: 10.1016/j.surg.2015.07.023. Epub 2015 Aug 18.


Risk factors for pancreatic cancer: underlying mechanisms and potential targets.

Edderkaoui M, Eibl G.

Front Physiol. 2014 Dec 10;5:490. doi: 10.3389/fphys.2014.00490. eCollection 2014. No abstract available.


Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells.

Ming M, Sinnett-Smith J, Wang J, Soares HP, Young SH, Eibl G, Rozengurt E.

PLoS One. 2014 Dec 10;9(12):e114573. doi: 10.1371/journal.pone.0114573. eCollection 2014.


Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method.

Lu QY, Zhang L, Lugea A, Moro A, Edderkaoui M, Eibl G, Pandol SJ, Go VL.

J Chromatogr Sep Tech. 2013 Jan 1;4(1). pii: 100062.


Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue β-glucuronidase.

Lu QY, Zhang L, Eibl G, Go VL.

J Pharm Biomed Anal. 2014 Jan;88:364-9. doi: 10.1016/j.jpba.2013.09.013. Epub 2013 Oct 5.


Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells.

Edderkaoui M, Lugea A, Hui H, Eibl G, Lu QY, Moro A, Lu X, Li G, Go VL, Pandol SJ.

Nutr Cancer. 2013;65(8):1232-44. doi: 10.1080/01635581.2013.832779. Epub 2013 Oct 15.


miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells.

Pham H, Rodriguez CE, Donald GW, Hertzer KM, Jung XS, Chang HH, Moro A, Reber HA, Hines OJ, Eibl G.

Biochem Biophys Res Commun. 2013 Sep 13;439(1):6-11. doi: 10.1016/j.bbrc.2013.08.042. Epub 2013 Aug 21.


Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cells.

Takahashi H, Chen MC, Pham H, Matsuo Y, Ishiguro H, Reber HA, Takeyama H, Hines OJ, Eibl G.

Biochim Biophys Acta. 2013 Dec;1833(12):2980-7. doi: 10.1016/j.bbamcr.2013.08.006. Epub 2013 Aug 14.


High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model.

Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G.

Cancer Prev Res (Phila). 2013 Oct;6(10):1064-73. doi: 10.1158/1940-6207.CAPR-13-0065. Epub 2013 Aug 13.


Role of pancreatic cancer-derived exosomes in salivary biomarker development.

Lau C, Kim Y, Chia D, Spielmann N, Eibl G, Elashoff D, Wei F, Lin YL, Moro A, Grogan T, Chiang S, Feinstein E, Schafer C, Farrell J, Wong DT.

J Biol Chem. 2013 Sep 13;288(37):26888-97. doi: 10.1074/jbc.M113.452458. Epub 2013 Jul 23.


Perioperative antibiotics for surgical site infection in pancreaticoduodenectomy: does the SCIP-approved regimen provide adequate coverage?

Donald GW, Sunjaya D, Lu X, Chen F, Clerkin B, Eibl G, Li G, Tomlinson JS, Donahue TR, Reber HA, Hines OJ.

Surgery. 2013 Aug;154(2):190-6. doi: 10.1016/j.surg.2013.04.001. Epub 2013 May 10.


Metformin inhibits the growth of human pancreatic cancer xenografts.

Kisfalvi K, Moro A, Sinnett-Smith J, Eibl G, Rozengurt E.

Pancreas. 2013 Jul;42(5):781-5. doi: 10.1097/MPA.0b013e31827aec40.


Baicalein--an intriguing therapeutic phytochemical in pancreatic cancer.

Donald G, Hertzer K, Eibl G.

Curr Drug Targets. 2012 Dec;13(14):1772-6. Review.


The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo.

Angst E, Park JL, Moro A, Lu QY, Lu X, Li G, King J, Chen M, Reber HA, Go VL, Eibl G, Hines OJ.

Pancreas. 2013 Mar;42(2):223-9. doi: 10.1097/MPA.0b013e318264ccae.


Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells.

Pham H, Chen M, Takahashi H, King J, Reber HA, Hines OJ, Pandol S, Eibl G.

Pancreas. 2012 Nov;41(8):1306-15. doi: 10.1097/MPA.0b013e31824d64d9.

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