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Items: 1 to 20 of 176

1.

Estimation of the receptor-state affinity constants of ligands in functional studies using wild type and constitutively active mutant receptors: Implications for estimation of agonist bias.

Ehlert FJ, Stein RS.

J Pharmacol Toxicol Methods. 2017 Jan - Feb;83:94-106. doi: 10.1016/j.vascn.2016.09.007. Epub 2016 Oct 7.

PMID:
27725245
2.

Cooperativity Has Empirical and Ultimate Levels of Explanation.

Ehlert FJ.

Trends Pharmacol Sci. 2016 Aug;37(8):620-3. doi: 10.1016/j.tips.2016.06.001. Epub 2016 Jun 27.

3.

Functional studies cast light on receptor states.

Ehlert FJ.

Trends Pharmacol Sci. 2015 Sep;36(9):596-604. doi: 10.1016/j.tips.2015.05.008. Epub 2015 Jun 26. Review.

4.

Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors.

DiMattio KM, Ehlert FJ, Liu-Chen LY.

Eur J Pharmacol. 2015 Aug 15;761:235-44. doi: 10.1016/j.ejphar.2015.05.054. Epub 2015 Jun 6.

5.

A novel method for analyzing extremely biased agonism at G protein-coupled receptors.

Stahl EL, Zhou L, Ehlert FJ, Bohn LM.

Mol Pharmacol. 2015 May;87(5):866-77. doi: 10.1124/mol.114.096503. Epub 2015 Feb 13.

6.

A kinetic model of GPCRs: analysis of G protein activity, occupancy, coupling and receptor-state affinity constants.

Stein RS, Ehlert FJ.

J Recept Signal Transduct Res. 2015;35(4):269-83. doi: 10.3109/10799893.2014.975250. Epub 2014 Oct 29.

PMID:
25353707
7.

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ.

Pharmacol Rev. 2014 Oct;66(4):918-47. doi: 10.1124/pr.114.008862.

8.

Estimation of ligand affinity constants for receptor states in functional studies involving the allosteric modulation of G protein-coupled receptors: implications for ligand bias.

Ehlert FJ, Griffin MT.

J Pharmacol Toxicol Methods. 2014 May-Jun;69(3):253-79. doi: 10.1016/j.vascn.2014.01.002. Epub 2014 Jan 13.

10.

What ligand-gated ion channels can tell us about the allosteric regulation of G protein-coupled receptors.

Ehlert FJ.

Prog Mol Biol Transl Sci. 2013;115:291-347. doi: 10.1016/B978-0-12-394587-7.00007-5. Review.

PMID:
23415097
11.

Reduction in inappropriate therapy and mortality through ICD programming.

Moss AJ, Schuger C, Beck CA, Brown MW, Cannom DS, Daubert JP, Estes NA 3rd, Greenberg H, Hall WJ, Huang DT, Kautzner J, Klein H, McNitt S, Olshansky B, Shoda M, Wilber D, Zareba W; MADIT-RIT Trial Investigators..

N Engl J Med. 2012 Dec 13;367(24):2275-83. doi: 10.1056/NEJMoa1211107. Epub 2012 Nov 6.

12.

Quantifying agonist activity at G protein-coupled receptors.

Ehlert FJ, Suga H, Griffin MT.

J Vis Exp. 2011 Dec 26;(58):e3179. doi: 10.3791/3179.

13.

Muscarinic agonists and antagonists: effects on gastrointestinal function.

Ehlert FJ, Pak KJ, Griffin MT.

Handb Exp Pharmacol. 2012;(208):343-74. doi: 10.1007/978-3-642-23274-9_15. Review.

PMID:
22222706
14.

Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard.

Yoshida A, Seki M, Nasrin S, Otsuka A, Ozono S, Takeda M, Masuyama K, Araki I, Ehlert FJ, Yamada S.

Urology. 2011 Sep;78(3):721.e7-721.e12. doi: 10.1016/j.urology.2011.05.011. Epub 2011 Jul 20.

PMID:
21777958
15.

Twelve hours of sustained ventricular fibrillation supported by a continuous-flow left ventricular assist device.

Sims DB, Rosner G, Uriel N, González-Costello J, Ehlert FA, Jorde UP.

Pacing Clin Electrophysiol. 2012 May;35(5):e144-8. doi: 10.1111/j.1540-8159.2011.03159.x. Epub 2011 Jun 16.

PMID:
21679198
16.

Analysis of functional responses at G protein-coupled receptors: estimation of relative affinity constants for the inactive receptor state.

Ehlert FJ, Griffin MT, Suga H.

J Pharmacol Exp Ther. 2011 Aug;338(2):658-70. doi: 10.1124/jpet.111.179291. Epub 2011 May 16.

17.
18.

Rate responsive pacing using cardiac resynchronization therapy in patients with chronotropic incompetence and chronic heart failure.

Sims DB, Mignatti A, Colombo PC, Uriel N, Garcia LI, Ehlert FA, Jorde UP.

Europace. 2011 Oct;13(10):1459-63. doi: 10.1093/europace/eur127. Epub 2011 May 7.

PMID:
21551475
19.

Changes in low right atrial conduction times during pulmonary vein isolation for atrial fibrillation: correlation with inducibility of typical right atrial flutter.

Dizon J, Biviano A, Whang W, Ehlert F, Garan H.

Europace. 2011 Jul;13(7):942-8. doi: 10.1093/europace/eur033. Epub 2011 Mar 21.

PMID:
21427089
20.

A comparison of long-standing implantable cardioverter-defibrillator patients with and without appropriate therapy for ventricular arrhythmias: impact of a widening QRS.

Dizon J, Chen K, Dizon S, Biviano A, Whang W, Ehlert F, Vazquez J, Nazif T, Garan H.

Europace. 2011 Jan;13(1):77-81. doi: 10.1093/europace/euq363. Epub 2010 Oct 6.

PMID:
21149513

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