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N Engl J Med. 2018 Oct 18;379(16):1519-1528. doi: 10.1056/NEJMoa1803955. Epub 2018 Sep 16.

Effect of Aspirin on All-Cause Mortality in the Healthy Elderly.

Collaborators (2137)

Chan A, Demons J, Espinoza S, Goetz M, Liew D, Meyskens F, Zalcberg J, Ives D, Berk M, Bernstein W, Brauer D, Burns C, Chong T, Cloud G, Eaton C, Fitzgerald P, Haydon A, Jelinek M, Macrae F, Mahady S, Malik M, McLean C, Rodriguez L, Satterfield S, Tie J, van Londen G, Ward S, Wood E, Mohr J, Anderson G, Connolly S, Friedman L, Manson J, Sano M, Morrison S, Ohman EM, Hadley E, Hannah J, Romashkan S, Ford L, Richmond E, Umar A, Lockett T, Lewis B, Obisesan T, Gilbertson D, Collyer T, Rigby J, Pruksawongsin K, Hay N, Jachno K, Smith C, Ekram ARMS, Gardam M, Luong H, Montgomery T, Plate M, Rojas L, Tominaga A, Wadeson K, Hopkins S, Nichols T, Johnson A, Prozinski M, Robinson-O’Brien R, Tessum N, Aloia J, Anton S, Burns J, Burton G, Ferris D, Honasoge M, Hsia D, Katzman S, Kottam A, Nesbitt S, Ochoa A, Pemu P, Peterson K, Powell J, Pressman G, Robinson W III, Satterfield S, Thorburn C, Volpi E, Wiggins J, Wilson P, Womack C, Abdullah M, Abdul-Ridha S, Aboud E, Abraham A, Abraham J, Abraham K, Abrahams M, Adad S, Adams C, Africa N, Afroze S, Agarwal D, Agbarakwe C, Ah Sang W, Ahern T, Ahmad Y, Ahmad Z, Ahmed L, Ajam A, Akhter R, Akram Z, Alagarswami K, Alam M, Alavi E, Aldridge L, Alethan A, Alexander K, Alexander L, Alexopoulos M, Ali B, Ali M, Allan J, Allen C, Allen G, Allen S, Allin P, Al-Musawy R, Alpren C, Al-Tawil I, Alwyn T, Amor P, Anam T, Anderson G, Anderson L, Anderson N, Anderson P, Anderson R, Anderson-Dalheim H, Andrada E, Andre S, Andrews L, Andric A, Andric M, Ang J, Ansari A, Arakji AM, Arambeploa Y, Ark R, Arnaudon FP, Arndt PM, Aroney T, Arthurson J, Arunachalam T, Asim N, Aslam I, Assad S, Astley N, Athari M, Atkins C, Atkins M, Aufgang M, Aung K, Aurora G, Auteri S, Avergun A, Awwad A, Azad C, Azra S, Babovic A, Baig M, Baker J, Baker S, Baker T, Bakhilova N, Baldam A, Baldassa A, Baldi C, Balkwill C, Balogun O, Ban A, Banerjee P, Banning M, Bansal S, Barkas R, Barker A, Barker D, Barnes A, Barnes N, Barnetson W, Barratt I, Barrett DA, Barrett M, Barrett M, Barrett P, Barrett T, Barson P, Barstad C, Barton W, Bartram M, Bartusek P, Basser S, Bassett S, Batchelor L, Batt D, Batty A, Baum S, Baxter M, Beaton G, Beaumont J, Beavis D, Beckett V, Beech M, Beilby J, Bekal S, Bell A, Bendtsen L, Benedict D, Benjamin T, Bennett P, Bennie G, Bennie S, Bennison S, Benson A, Benson R, Benson S, Bergin J, Bergin S, Berryman G, Berryman J, Bertram H, Bertuch G, Bettenay G, Bettiol L, Bills R, Birch J, Bird R, Bird R, Birks R, Blake R, Blakney A, Blashki M, Bleach G, Bloch B, Bodenstein M, Boga V, Bollen C, Boltin P, Boon B, Booth G, Borg A, Bornstein D, Bottcher C, Bourke J, Bourke M, Boutcher S, Bowden J, Bowen J, Bowring B, Boyce C, Boyd J, Brack R, Bradshaw A, Brady P, Braithwaite J, Braude G, Brayshaw N, Breen M, Bresnahan R, Briddon P, Bridge A, Briggs SJ, Brimage RF, Britten-Jones W, Brkic M, Broadby M, Bromberger D, Brommeyer A, Broom I, Brophy T, Brough J, Brougham JP, Broun C, Brown ID, Brown J, Brown MB, Brown MP, Brown R, Brownbill C, Brownbill L, Browne M, Brownstein M, Bruce A, Brunacci F, Brunner C, Bruorton M, Buccheri V, Buchanan D, Buckley J, Bulle B, Bundy K, Burke M, Busch G, Bush CP, Butrev A, Bvirakare J, Bvumbura BF, Bye J, Byrne C, Byrne P, Cain M, Calcutt I, Calder K, Caldwell M, Callan C, Cameron A, Cameron D, Cameron D, Cameron T, Campbell D, Campbell D, Campbell G, Campbell G, Campbell PH, Campbell R, Carroll N, Carroll V, Carson J, Carson R, Carter L, Carter P, Carter R, Carter S, Cartwright P, Cassidy P, Catchpole M, Cato G, Celada R, Chai F, Chalabi A, Chalissery P, Chalmers ML, Chamberlain H, Chamoun R, Chan B, Chan C, Chan CK, Chan FW, Chan K, Chandran S, Chandrananth M, Chandrananth S, Chang C, Chang V, Chang W, Changakoti A, Chantler R, Chao D, Chao S, Charlton P, Chattersee A, Chau G, Chaung Y, Chawtur V, Cheah HH, Cheah S, Cheasley A, Chee H, Chen D, Cheng W, Chesney D, Chew D, Chhabra P, Chia I, Chia P, Chiang A, Chiang S, Chiew I, Chiew L, Chikarsal A, Chin J, Chin M, Chipman JS, Chipperfield C, Chisholm H, Chisholm L, Chiu A, Chiu C, Chiu D, Chiu T, Chizik L, Choksey H, Choo E, Chow A, Chow A, Choy C, Chu S, Chua A, Chuah T, Chung J, Cimpoescu T, Clapton J, Clark B, Clark B, Clark M, Clark R, Clarke A, Clarke D, Clarke S, Cleary G, Clerigo L, Clohesy S, Close S, Cochrane F, Cohen IS, Cohen J, Colahan R, Collins J, Colman W, Colvin R, Conde S, Connell P, Connellan M, Connor W, Connors G, Conos M, Conron D, Conroy J, Conway C, Cooper M, Cooper S, Cope A, Corrigan S, Corrigan S, Coughlan P, Coulter E, Counsel L, Court D, Courtis G, Cousens A, Craig L, Crameri M, Cranswick M, Crawford J, Crawford M, Crawford P, Crawford R, Crick S, Crimmins B, Cristofaro R, Croatto J, Crompton A, Cronin E, Crookes J, Cross B, Cross D, Cross M, Crow P, Crowe JE, Crowe P, Crowley H, Cruickshank J, Cummins R, Cunneen A, Cunningham A, Cunningham N, Cunningham P, Curnow D, Curran J, Curran M, Currie A, Curtis R, Cusack J, Dabash K, Dabestani V, Dadabhay Z, Daglas D, Dagley P, Danesh S, Dang D, Daniels R, Darby JP, Darko N, Darling J, Darlington B, Das J, Das P, Date M, Datta C, Datta S, Davenport C, Davey G, Davey M, Davey P, Davidson CL, Davidson D, Davies M, Davies-Hakeem A, Davis G, Davis K, Davis P, Davis P, Davis S, Dawe N, Dawes R, Dawkins P, Dawson G, Dawson P, Dawson R, Day P, Daya M, Dayasagar D, D’Costa L, De Clifford M, De Gleria S, De Poi C, De Silva M, De Silva P, De Steiger R, De Villiers D, De Wit E, Debnath R, Deery R, De Lanerolle D, Del Rio F, Delaney S, Delitzsch SS, Demaio F, Demian M, Demirtzoglou J, Denton T, Derrick L, Deshmukh K, Dessauer J, Devavittiya C, Devereux D, Dewan D, Dewhurst H, Dhar A, Dhillon D, Di Carlo M, Di Dio A, Di Marco A, Dickman J, Dillon L, Dinh QT, Dissanayake D, Dissanayake M, Dissanayake T, Divakaran K, Dixit U, Dixon H, Dixon N, Djakic E, Dobson C, Dodd L, Dodds P, Dodic A, Dodic M, Doley A, Dolguina S, Dolling C, Donaghy F, Donald H, Donelan E, Donohue M, Dooland J, Dooley H, Doslo S, Douglas A, Dover P, Downe G, Drake P, Dry D, Duane P, Dubash A, Dubetz D, Duff P, Duke R, Dumitrescu C, Dunbar A, Dunbar S, Dunn S, Duong NH, Dutta N, Dutton M, Duval A, Dyson-Berry J, Eade P, Eaton D, Ebert K, Edib K, Edillo E, Edmonds J, Edwards F, Edwards PA, Edwards S, Eftekharuddin M, Egan A, Egan P, Ehrenreich S, Ehsan E, Elberg L, Elisha B, Elisha R, Elkhoury H, Ellerton K, Elliot-Smith A, Elmore R, Elshenawy I, Elsherif S, Elsouki M, Elton P, Emmerson M, Emmett SI, English J, Enten P, Entwistle J, Epa W, Erhardt A, Etta J, Evans M, Everitt T, Ewing J, Fahkok B, Faigen M, Fair A, Fairbrother C, Fanning J, Fantasia M, Farag E, Fardell K, Farrant J, Farrell P, Farrow J, Fassett M, Faull PA, Ferguson P, Fernando S, Fernando S, Ferruccio A, Fidge JH, Field P, Figurireo L, Fisher H, Fisher J, Fitzgerald E, Fitzgerald M, Fitzgerald R, Fitzpatrick H, Fitzpatrick J, Fitzpatrick P, Fitzpatrick T, Flaherty P, Flanagan D, Flanagan T, Flew S, Fonseka PP, Foo J, Foo S, Foo Y, Foong E, Ford D, Foster D, Fourlanos V, Fowler I, Fox D, Fox F, Fox M, Fox P, Fox-Smith D, Francis J, Francis R, Frank O, Franks A, Fredericks A, Freeman E, French L, Frew B, Friebel D, Friebel T, Frost S, Fryer D, Fuller J, Fung W, Fung WP, Furphy S, Gabutina C, Gaggin S, Galbraith S, Gale M, Gall J, Gallichio V, Gangell AW, Garde MA, Gardner SS, Gardner T, Garland J, Garra G, Garrow S, Garvey J, Gauden M, Gault A, Gaur D, Gavralas A, George N, George S, Georgy M, Gerendasi R, Geschke H, Giannakakis J, Gidley G, Gilani M, Giles P, Gill K, Gill P, Gill R, Gillis C, Gilmore A, Gilovitz M, Gingold R, Glaspole D, Glowinski L, Glue AL, Godakumbura P, Godavarthy R, Goel A, Goeltom C, Goldberg E, Goldberg J, Golets M, Gong V, Goode J, Goodman C, Goodwin RJ, Gopathy S, Gordon M, Gough S, Govender M, Gow K, Gowrie B, Goy P, Grabowski C, Graddon J, Granek A, Gray JM, Gray M, Gray T, Grbac E, Greacen J, Greculescu E, Green J, Greenwood E, Griffin E, Griffith V, Griffiths A, Griffiths G, Griffiths J, Griffiths K, Grigorian AR, Grinzi P, Grogan H, Grokop G, Grossman L, Grove A, Gruzauskas A, Gu M, Guest S, Guindi N, Guo H, Gurney R, Guy J, Guymer J, Gwynn R, Gyorki J, Habibi S, Hachem C, Hackett A, Hackett J, Haddad J, Haddad M, Hadley E, Hagger R, Haider Z, Hain R, Hajicosta T, Hales P, Hall J, Hall P, Hall R, Hall R, Hall S, Halliburton K, Halliday A, Halliday B, Halliday J, Hamblen K, Hamel J, Hamer I, Hamilton J, Hamilton RF, Hammond T, Hanbury R, Hancock A, Hand R, Hanna A, Hanna M, Hanna S, Hanson G, Hanson PD, Haque E, Haran C, Haran T, Hare WJ, Harewood A, Haripersad S, Harman A, Harmer D, Harms P, Harnden C, Harrington M, Harris A, Harris M, Harrison M, Harrison S, Hart E, Hartley D, Hartley P, Hartnett M, Harvey C, Haslam K, Hassani I, Hassett RB, Hastings W, Hattingh A, Hawke I, Hawkins C, Hayes V, Heale J, Healy G, Hebblewhite A, Hechtman A, Hedgland A, Heffernan C, Heikkinen MN, Heinrich C, Henderson J, Henry F, Herath S, Herbert A, Herbst D, Hermiz S, Herrman J, Hesse M, Hetherington J, Hetzel R, Hewett R, Hides R, Higgins CD, Hildred S, Hill A, Hilton C, Hince R, Hines C, Hinton C, Hipolito A, Ho CK, Ho L, Hoar J, Hocking L, Hodge A, Hodgkins A, Hodgson J, Hogbin J, Hok S, Holder B, Holland D, Holland M, Hollins B, Homewood M, Hong Zhou A, Honig J, Honigman S, Hookham D, Hooper W, Hope L, Horman J, Horng T, Hornstein I, Horriat M, Horvat J, Hossain M, Hough P, Howe J, Howson W, Hubczenko I, Hubel M, Hughes J, Hughes P, Hunter D, Huq S, Hussain A, Hutchins I, Hutchinson A, Hyam P, Hyare K, Iakovidis B, Ibragimov M, Idris M, Ierace C, Ikladios A, Imgraben P, Ingham C, Ip A, Ip Y, Iqbal A, Iqbal M, Irvine G, Irwin V, Iser D, Islam N, Islam S, Isles JK, Ismail A, Ivanoff G, Iwe N, Jackett RB, Jackson M, Jackson N, Jackson P, Jackson T, Jacoup M, Jaensch E, Jain P, Jain S, Jaiswal N, Jaksic A, Jakubowicz I, Jamel B, James J, Jameson D, Jansz C, Jarman E, Jassi I, Jayasinghe S, Jayatilake J, Jayaweera V, Jeanes R, Jeanneret CI, Jedynak S, Jeffries L, Jegadeesh K, Jenkins P, Jennings C, Jenny C, Jiang YY, Jigau C, Jinadasa C, Joel S, John R, Johns P, Johnson C, Johnson J, Johnson M, Johnson N, Johnson W, Johnston B, Johnston K, Johnston M, Johnston R, Johnston T, Jones G, Jones I, Jones L, Jones M, Jones S, Jones T, Jones T, Joshi M, Joshi N, Joshi N, Joske F, Joubert C, Jovanovic B, Joyce R, Judd AM, Judd J, Kaaden JP, Kabat L, Kabourakis F, Kaippilly A, Kajani H, Kamale A, Kaminsky L, Kanapathipillai U, Kanashuk L, Kao R, Kapadia P, Kapadia V, Karmouche R, Kaur KJ, Kavanagh T, Kay A, Kay B, Kaye S, Keane K, Keating B, Keecha E, Keecha J, Keenan P, Keillar P, Kemp G, Kemp P, Kennedy M, Kennedy U, Kennett S, Kesarapu S, Khan F, Khan I, Khan M, Khong CK, Khoo F, Khoo J, Khoo S, Khoshghalb A, Kiefer J, Kiley M, Kilov G, Kimpton N, King SC, Kingston R, Kinsella P, Kipouridis A, Kirwan A, Kisselev S, Kitchen J, Kloot S, Knaggs J, Knight E, Knobel J, Knowles D, Knowles P, Kogosowski S, Kok J, Kok J, Kollios D, Konopnicki H, Koravos A, Korol P, Kosky AR, Kote Somashekarappa M, Kottegoda-Vithana E, Kotur S, Kozminsky M, Kraner G, Kraus DH, Krell I, Kruytbosch C, Kuay V, Kucminska A, Kulatunga P, Kulinski M, Kumar J, Kumar R, Kumar S, Kumarage D, Kumaraswamy S, Kunze M, Kurien S, Kuruvilla P, Kwong R, Kyaw Z, Kyriacopoulos J, Lackner PJ, Lahanis C, Lajoie D, Lajoie K, Lakshmanan A, Lal A, Lalor E, Lam D, Lambooij C, Lancaster M, Landa L, Landers J, Lane R, Langston K, Lapin S, Lath P, Lau-Gooey T, Lawlor-Smith L, Le Couteur S, Le P, Le Riche M, Le V, Le W, Leber D, Ledner A, Lee B, Lee C, Lee D, Lee FB, Lee J, Lee J, Lee JY, Lee J, Lees K, Lees R, Lees W, Leffler P, Lenton J, Leong R, Leow L, Leow P, Leow Y, Leslie N, Lester SE, Lewi L, Lewis P, Lewis R, Li A, Li J, Liang J, Liang X, Libhaber H, Lichtblau B, Lickiss T, Liedvogel M, Liew K, Light L, Lightfoot W, Lim C, Lim D, Lim H, Lim HS, Lim J, Lim SG, Limaye S, Limbu Y, Lindenmayer J, Lindstedt P, Lines A, Ling J, Ling R, Linton J, Linton S, Linton T, Liow C, Liow YC, Lip L, Lipson D, Liu S, Liu Y, Liubinas R, Liveriadis T, Lizner S, Lloyd M, Lo B, Lo C, Lock P, Lockhart M, Logan M, Loke KP, Long M, Long M, Longworth W, Loo KH, Lopez-Hernandez S, Lord RJ, Louw J, Louw TT, Low B, Low F, Lowe M, Lowther D, Loxley P, Lu P, Lu S, Lucarelli A, Lui G, Lui K, Lui R, Luke C, Lukic N, Lupton J, Luscombe T, Luttrell CL, Lyall A, Lynch J, Lynn K, Lyon D, Lyon E, Lyons S, Macaulay G, Macaulay K, MacIndoe A, MacIsaac P, Maciver R, Mackay B, Mackay J, Mackinnon D, Mackle R, Macphail J, Madawala N, Madden J, Madeley C, Madhanpall N, Magarey J, Magill M, Mah S, Mahadeva SP, Mahendran S, Maher J, Maher M, Mahmood A, Mahmood A, Maier K, Majchrzak W, Majeed J, Makar A, Makohon R, Malcher P, Malcolm HE, Malcolm M, Mallett S, Mallik A, Manderson J, Mane S, Mangan G, Manifold M, Manoliadis M, Manovel B, Mansour A, Manton D, Marano F, Marchant D, Mariajoseph G, Marinos A, Marinucci D, Marrows M, Marsh D, Martin C, Martin G, Martin R, Marton F, Martynova L, Mason N, Masood U, Massaud M, Massy-Westropp P, Masters B, Mather J, Mathews RA, Mathieson G, Mauro M, Mauviel PA, Maxfield N, Mayhead C, Mazengiya S, Mazhar A, Mbachilin G, McAllan A, McCallum H, McCann N, McCarthy A, McCleary A, McClelland R, McConville DS, McCorkell J, McCormack G, McCormick H, McCowan M, McCutcheon J, McDonald AG, McDonald AS, McDonald IR, McDonald J, McDonald N, McDonald S, McEniery A, McEntee K, McGee R, McGinity P, McGowan N, McGowan R, McGrath L, McGuire P, McGuire P, McHardy C, McHenry K, McIllree R, McKay M, McKellar C, McKelvie M, McKenzie SI, McKeown J, McKeown M, McKernan S, McKinnon A, McLaren G, McLeod I, McMahon A, McMaster I, McNab NR, McNaughton EL, McNiff M, McPherson C, Meaney J, Medlicott M, Medres R, Megally R, Mehta K, Mellios O, Melvani R, Mencel J, Mendick S, Mendis L, Menzies J, Mercado M, Mesiha S, Meyer PL, Meyer R, Miceli A, Michaelson T, Michail A, Michelmore K, Miezis V, Milan S, Milky S, Miller K, Milner J, Milone R, Milton C, Milward N, Mirhom R, Mirranay S, Mishricky H, Misso R, Mitchell A, Mitchell D, Mitchell L, Mobilia G, Moffitt M, Mohr V, Moller G, Moller G, Molloy P, Molloy T, Molyneux P, Monaghan C, Monash D, Moncrieff S, Monzon M, Mooney T, Moore E, Moran J, Morgan G, Morgan M, Morgan N, Morris N, Morris S, Morrison H, Morrow S, Morton R, Moschou C, Moulding S, Moule V, Mouzakis V, Mudunna D, Mudzi S, Mulkearns P, Mullen D, Mulvey G, Mungi D, Munro L, Muraledaran S, Murphy B, Murphy G, Murray A, Murray B, Murray E, Murray H, Murray S, Murtagh C, Nadarajah M, Naiker S, Naing W, Nandha R, Nankervis J, Naoum A, Nash C, Nashed M, Nasreen N, Nath-Chand U, Neagle M, Nelson C, Nelson MR, Nesbitt P, Neuberger M, Newman S, Newton S, Ng D, Ng H, Ng S, Nguyen D, Nguyen HQ, Nguyen HT, Nguyen T, Nguyen-Ngoc M, Nice P, Nicholls P, Nicholson D, Nicola N, Nicolettou N, Nicolson I, Nield S, Nikolic V, Nikolovska-Buzevski N, Nilsson A, Nimmo A, Nisselle P, Nitchingham S, Niven A, Nnopu E, Noonan L, Norton C, Norton G, Notini G, Nwaegerue ED, Nylander P, O’Brien C, O’Connor A, O’Connor DA, O’Donovan B, O’Driscoll E, Oechsle G, Offor J, Ogilvie B, O’Halloran J, O’Hanlon P, Okolie K, Olaniyi I, O’Leary B, O’Leary K, Olesen J, Oliver P, Olomola O, Olszewski C, Olukolu G, Omarjee A, Omidiora AA, Omifolaji S, O’Neill A, O’Neill CO, Ong BP, Ong M, Ooruthiran M, Oppermann BL, Orbach E, Orgonas R, Orsillo M, Ostberg M, O’Sullivan C, O’Sullivan J, O’Sullivan PJ, O’Toole C, O’Toole M, Otuonye D, Owen T, Padilla C, Page A, Pahuja P, Palmer A, Pan J, Panozzo D, Pantillano E, Papagelis A, Papas E, Pape A, Paransothy P, Parghi N, Parker A, Parker J, Parker S, Parkes H, Parletta E, Parry B, Pasha M, Patel G, Patel M, Pathirana A, Patterson R, Pattichis I, Pattison J, Pava C, Peachey D, Pearce E, Pearce R, Pearse B, Pearson R, Pech M, Peduru-Arachchige A, Pellegrini P, Pellizzari G, Pereira V, Perera B, Perera L, Perlesz A, Perraton R, Perry H, Perry S, Perry W, Pervaiz Z, Peters L, Pham H, Phan C, Phan T, Phare A, Philip J, Philips J, Phillips A, Philpot J, Phiri R, Pickavance M, Piekarski D, Pienkos J, Piez W, Pilgrim C, Pillai BK, Pinder R, Pinkstone J, Pinson J, Pither A, Plenderleith J, Pliatsios B, Plunkett M, Pokharel C, Poland D, Polgar V, Polmear D, Poologanathan G, Pope I, Popp L, Portelli A, Potter T, Powell K, Powell K, Powell V, Power R, Powles A, Poynton N, Pranavan S, Prasad R, Praszkier S, Preiss J, Pretorius P, Price C, Price I, Price K, Price M, Priest C, Pring M, Profitt C, Protassow A, Psaradellis IJA, Psycharis J, Pucilowski D, Pun K, Qamar F, Quach S, Radcliff E, Radcliffe B, Radcliffe J, Radford J, Ragg P, Rahel E, Rahim T, Rahman F, Rahmanamlashi N, Rajasooriar S, Rajendra I, Rajini E, Raman A, Ramsay A, Ramsey J, Rana U, Rankin M, Rao UV, Rapley M, Rasaratnam S, Rashid A, Ratnaike L, Rattan J, Ratten K, Rattraywood C, Rayner E, Rea J, Rea PC, Reddy S, Reddy S, Reed R, Reeves C, Reichl T, Reid J, Reid K, Remyn P, Renfrey S, Renouf E, Renshaw P, Retchford A, Reynolds F, Reza R, Rezk L, Rhee J, 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Abstract

BACKGROUND:

In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-free survival among older adults. A numerically higher rate of the secondary end point of death from any cause was observed with aspirin than with placebo.

METHODS:

From 2010 through 2014, we enrolled community-dwelling persons in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanics in the United States) and did not have cardiovascular disease, dementia, or disability. Participants were randomly assigned to receive 100 mg of enteric-coated aspirin or placebo. Deaths were classified according to the underlying cause by adjudicators who were unaware of trial-group assignments. Hazard ratios were calculated to compare mortality between the aspirin group and the placebo group, and post hoc exploratory analyses of specific causes of death were performed.

RESULTS:

Of the 19,114 persons who were enrolled, 9525 were assigned to receive aspirin and 9589 to receive placebo. A total of 1052 deaths occurred during a median of 4.7 years of follow-up. The risk of death from any cause was 12.7 events per 1000 person-years in the aspirin group and 11.1 events per 1000 person-years in the placebo group (hazard ratio, 1.14; 95% confidence interval [CI], 1.01 to 1.29). Cancer was the major contributor to the higher mortality in the aspirin group, accounting for 1.6 excess deaths per 1000 person-years. Cancer-related death occurred in 3.1% of the participants in the aspirin group and in 2.3% of those in the placebo group (hazard ratio, 1.31; 95% CI, 1.10 to 1.56).

CONCLUSIONS:

Higher all-cause mortality was observed among apparently healthy older adults who received daily aspirin than among those who received placebo and was attributed primarily to cancer-related death. In the context of previous studies, this result was unexpected and should be interpreted with caution. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrials.gov number, NCT01038583 .).

PMID:
30221595
PMCID:
PMC6433466
DOI:
10.1056/NEJMoa1803955
[Indexed for MEDLINE]
Free PMC Article

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