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Items: 1 to 20 of 39


Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease.

Wolfs JM, Hamilton TA, Lant JT, Laforet M, Zhang J, Salemi LM, Gloor GB, Schild-Poulter C, Edgell DR.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):14988-14993. doi: 10.1073/pnas.1616343114.


Perpetuating the homing endonuclease life cycle: identification of mutations that modulate and change I-TevI cleavage preference.

Roy AC, Wilson GG, Edgell DR.

Nucleic Acids Res. 2016 Sep 6;44(15):7350-9. doi: 10.1093/nar/gkw614.


MegaTevs: single-chain dual nucleases for efficient gene disruption.

Wolfs JM, DaSilva M, Meister SE, Wang X, Schild-Poulter C, Edgell DR.

Nucleic Acids Res. 2014 Jul;42(13):8816-29. doi: 10.1093/nar/gku573.


Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues.

McMurrough TA, Dickson RJ, Thibert SM, Gloor GB, Edgell DR.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2376-83. doi: 10.1073/pnas.1322352111.


Unifying the analysis of high-throughput sequencing datasets: characterizing RNA-seq, 16S rRNA gene sequencing and selective growth experiments by compositional data analysis.

Fernandes AD, Reid JN, Macklaim JM, McMurrough TA, Edgell DR, Gloor GB.

Microbiome. 2014 May 5;2:15. doi: 10.1186/2049-2618-2-15.


The I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENs.

Kleinstiver BP, Wang L, Wolfs JM, Kolaczyk T, McDowell B, Wang X, Schild-Poulter C, Bogdanove AJ, Edgell DR.

G3 (Bethesda). 2014 Apr 16;4(6):1155-65. doi: 10.1534/g3.114.011445.


Bacterial group I introns: mobile RNA catalysts.

Hausner G, Hafez M, Edgell DR.

Mob DNA. 2014 Mar 10;5(1):8. doi: 10.1186/1759-8753-5-8.


Rapid screening of endonuclease target site preference using a modified bacterial two-plasmid selection.

Wolfs JM, Kleinstiver BP, Edgell DR.

Methods Mol Biol. 2014;1123:97-104. doi: 10.1007/978-1-62703-968-0_8.


The monomeric GIY-YIG homing endonuclease I-BmoI uses a molecular anchor and a flexible tether to sequentially nick DNA.

Kleinstiver BP, Wolfs JM, Edgell DR.

Nucleic Acids Res. 2013 May 1;41(10):5413-27. doi: 10.1093/nar/gkt186.


Monomeric site-specific nucleases for genome editing.

Kleinstiver BP, Wolfs JM, Kolaczyk T, Roberts AK, Hu SX, Edgell DR.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8061-6. doi: 10.1073/pnas.1117984109.


Divalent metal ion differentially regulates the sequential nicking reactions of the GIY-YIG homing endonuclease I-BmoI.

Kleinstiver BP, Bérubé-Janzen W, Fernandes AD, Edgell DR.

PLoS One. 2011;6(8):e23804. doi: 10.1371/journal.pone.0023804.


Tapping natural reservoirs of homing endonucleases for targeted gene modification.

Takeuchi R, Lambert AR, Mak AN, Jacoby K, Dickson RJ, Gloor GB, Scharenberg AM, Edgell DR, Stoddard BL.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13077-82. doi: 10.1073/pnas.1107719108.


Learning to live together: mutualism between self-splicing introns and their hosts.

Edgell DR, Chalamcharla VR, Belfort M.

BMC Biol. 2011 Apr 11;9:22. doi: 10.1186/1741-7007-9-22. Review.


Estimating the evidence of selection and the reliability of inference in unigenic evolution.

Fernandes AD, Kleinstiver BP, Edgell DR, Wahl LM, Gloor GB.

Algorithms Mol Biol. 2010 Nov 8;5:35. doi: 10.1186/1748-7188-5-35.


Mobile DNA elements in T4 and related phages.

Edgell DR, Gibb EA, Belfort M.

Virol J. 2010 Oct 28;7:290. doi: 10.1186/1743-422X-7-290. Review.


Assembly of a fragmented ribonucleotide reductase by protein interaction domains derived from a mobile genetic element.

Crona M, Moffatt C, Friedrich NC, Hofer A, Sjöberg BM, Edgell DR.

Nucleic Acids Res. 2011 Mar;39(4):1381-9. doi: 10.1093/nar/gkq924.


Subunit and small-molecule interaction of ribonucleotide reductases via surface plasmon resonance biosensor analyses.

Crona M, Furrer E, Torrents E, Edgell DR, Sjöberg BM.

Protein Eng Des Sel. 2010 Aug;23(8):633-41. doi: 10.1093/protein/gzq035.


A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI.

Kleinstiver BP, Fernandes AD, Gloor GB, Edgell DR.

Nucleic Acids Res. 2010 Apr;38(7):2411-27. doi: 10.1093/nar/gkp1223.


Phage T4 mobE promotes trans homing of the defunct homing endonuclease I-TevIII.

Wilson GW, Edgell DR.

Nucleic Acids Res. 2009 Nov;37(21):7110-23. doi: 10.1093/nar/gkp769.

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