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Items: 18


TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.

Hurst LA, Dunmore BJ, Long L, Crosby A, Al-Lamki R, Deighton J, Southwood M, Yang X, Nikolic MZ, Herrera B, Inman GJ, Bradley JR, Rana AA, Upton PD, Morrell NW.

Nat Commun. 2017 Jan 13;8:14079. doi: 10.1038/ncomms14079.


Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.

Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M.

Diabetologia. 2016 Mar;59(3):502-11. doi: 10.1007/s00125-015-3837-8. Epub 2015 Dec 23.


Caveolae protect endothelial cells from membrane rupture during increased cardiac output.

Cheng JP, Mendoza-Topaz C, Howard G, Chadwick J, Shvets E, Cowburn AS, Dunmore BJ, Crosby A, Morrell NW, Nichols BJ.

J Cell Biol. 2015 Oct 12;211(1):53-61. doi: 10.1083/jcb.201504042.


Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.

Toshner M, Dunmore BJ, McKinney EF, Southwood M, Caruso P, Upton PD, Waters JP, Ormiston ML, Skepper JN, Nash G, Rana AA, Morrell NW.

PLoS One. 2014 Mar 20;9(3):e91334. doi: 10.1371/journal.pone.0091334. eCollection 2014.


The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations.

Dunmore BJ, Drake KM, Upton PD, Toshner MR, Aldred MA, Morrell NW.

Hum Mol Genet. 2013 Sep 15;22(18):3667-79. doi: 10.1093/hmg/ddt216. Epub 2013 May 12.


Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension.

Drake KM, Dunmore BJ, McNelly LN, Morrell NW, Aldred MA.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):403-9. doi: 10.1165/rcmb.2013-0100OC.


Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.

Long L, Yang X, Southwood M, Lu J, Marciniak SJ, Dunmore BJ, Morrell NW.

Circ Res. 2013 Apr 12;112(8):1159-70. doi: 10.1161/CIRCRESAHA.111.300483. Epub 2013 Feb 27.


Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis.

Affara M, Sanders D, Araki H, Tamada Y, Dunmore BJ, Humphreys S, Imoto S, Savoie C, Miyano S, Kuhara S, Jeffries D, Print C, Charnock-Jones DS.

BMC Genomics. 2013 Jan 16;14:23. doi: 10.1186/1471-2164-14-23.


MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms.

Affara M, Dunmore BJ, Sanders DA, Johnson N, Print CG, Charnock-Jones DS.

BMC Genomics. 2011 Jan 19;12:43. doi: 10.1186/1471-2164-12-43.


Bone morphogenetic protein type II receptor mutations causing protein misfolding in heritable pulmonary arterial hypertension.

Li W, Dunmore BJ, Morrell NW.

Proc Am Thorac Soc. 2010 Nov;7(6):395-8. doi: 10.1513/pats.201002-024AW. Review.


Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.

Durrington HJ, Upton PD, Hoer S, Boname J, Dunmore BJ, Yang J, Crilley TK, Butler LM, Blackbourn DJ, Nash GB, Lehner PJ, Morrell NW.

J Biol Chem. 2010 Nov 26;285(48):37641-9. doi: 10.1074/jbc.M110.132415. Epub 2010 Sep 24.


Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils.

Cowburn AS, Summers C, Dunmore BJ, Farahi N, Hayhoe RP, Print CG, Cook SJ, Chilvers ER.

Am J Respir Cell Mol Biol. 2011 Jun;44(6):879-87. doi: 10.1165/rcmb.2010-0101OC. Epub 2010 Aug 12.


Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques.

Dunmore BJ, McCarthy MJ, Naylor AR, Brindle NP.

J Vasc Surg. 2007 Jan;45(1):155-9.


Mutant Tie2 causing venous malformation signals through Shc.

Morris PN, Dunmore BJ, Brindle NP.

Biochem Biophys Res Commun. 2006 Jul 21;346(1):335-8. Epub 2006 May 30.


Characterization of the COMMD1 (MURR1) mutation causing copper toxicosis in Bedlington terriers.

Forman OP, Boursnell ME, Dunmore BJ, Stendall N, van den Sluis B, Fretwell N, Jones C, Wijmenga C, Rothuizen J, van Oost BA, Holmes NG, Binns MM, Jones P.

Anim Genet. 2005 Dec;36(6):497-501.


Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations.

Morris PN, Dunmore BJ, Tadros A, Marchuk DA, Darland DC, D'Amore PA, Brindle NP.

J Mol Med (Berl). 2005 Jan;83(1):58-63. Epub 2004 Oct 29.


ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1.

Tadros A, Hughes DP, Dunmore BJ, Brindle NP.

Blood. 2003 Dec 15;102(13):4407-9. Epub 2003 Aug 21.


Angiogenesis in chronically ischaemic human heart following percutaneous myocardial revascularisation.

Cotton JM, Thomas MR, Dunmore BJ, Salisbury J, Shah AM, Brindle NP.

Heart. 2002 Mar;87(3):281-3. No abstract available.

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