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Exons 45-55 Skipping Using Mutation-Tailored Cocktails of Antisense Morpholinos in the DMD Gene.

Echigoya Y, Lim KRQ, Melo D, Bao B, Trieu N, Mizobe Y, Maruyama R, Mamchaoui K, Tanihata J, Aoki Y, Takeda S, Mouly V, Duddy W, Yokota T.

Mol Ther. 2019 Nov 6;27(11):2005-2017. doi: 10.1016/j.ymthe.2019.07.012. Epub 2019 Jul 26.


A Systematic Review of Suggested Molecular Strata, Biomarkers and Their Tissue Sources in ALS.

Vijayakumar UG, Milla V, Cynthia Stafford MY, Bjourson AJ, Duddy W, Duguez SM.

Front Neurol. 2019 May 14;10:400. doi: 10.3389/fneur.2019.00400. eCollection 2019. Review.


Muscle Gene Sets: a versatile methodological aid to functional genomics in the neuromuscular field.

Malatras A, Duguez S, Duddy W.

Skelet Muscle. 2019 May 3;9(1):10. doi: 10.1186/s13395-019-0196-z.


Personalized Medicine and Molecular Interaction Networks in Amyotrophic Lateral Sclerosis (ALS): Current Knowledge.

Morgan S, Duguez S, Duddy W.

J Pers Med. 2018 Dec 13;8(4). pii: E44. doi: 10.3390/jpm8040044. Review.


Identification of Novel Antisense-Mediated Exon Skipping Targets in DYSF for Therapeutic Treatment of Dysferlinopathy.

Lee JJA, Maruyama R, Duddy W, Sakurai H, Yokota T.

Mol Ther Nucleic Acids. 2018 Dec 7;13:596-604. doi: 10.1016/j.omtn.2018.10.004. Epub 2018 Oct 11.


Antisense PMO cocktails effectively skip dystrophin exons 45-55 in myotubes transdifferentiated from DMD patient fibroblasts.

Lee J, Echigoya Y, Duddy W, Saito T, Aoki Y, Takeda S, Yokota T.

PLoS One. 2018 May 17;13(5):e0197084. doi: 10.1371/journal.pone.0197084. eCollection 2018.


Quantitative Antisense Screening and Optimization for Exon 51 Skipping in Duchenne Muscular Dystrophy.

Echigoya Y, Lim KRQ, Trieu N, Bao B, Miskew Nichols B, Vila MC, Novak JS, Hara Y, Lee J, Touznik A, Mamchaoui K, Aoki Y, Takeda S, Nagaraju K, Mouly V, Maruyama R, Duddy W, Yokota T.

Mol Ther. 2017 Nov 1;25(11):2561-2572. doi: 10.1016/j.ymthe.2017.07.014. Epub 2017 Jul 28.


Annexin A2 links poor myofiber repair with inflammation and adipogenic replacement of the injured muscle.

Defour A, Medikayala S, Van der Meulen JH, Hogarth MW, Holdreith N, Malatras A, Duddy W, Boehler J, Nagaraju K, Jaiswal JK.

Hum Mol Genet. 2017 Jun 1;26(11):1979-1991. doi: 10.1093/hmg/ddx065.


Skeletal muscle characteristics are preserved in hTERT/cdk4 human myogenic cell lines.

Thorley M, Duguez S, Mazza EMC, Valsoni S, Bigot A, Mamchaoui K, Harmon B, Voit T, Mouly V, Duddy W.

Skelet Muscle. 2016 Dec 8;6(1):43. doi: 10.1186/s13395-016-0115-5.


Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle.

Bigot A, Duddy WJ, Ouandaogo ZG, Negroni E, Mariot V, Ghimbovschi S, Harmon B, Wielgosik A, Loiseau C, Devaney J, Dumonceaux J, Butler-Browne G, Mouly V, Duguez S.

Cell Rep. 2015 Nov 10;13(6):1172-1182. doi: 10.1016/j.celrep.2015.09.067. Epub 2015 Oct 29.


Changes in Communication between Muscle Stem Cells and their Environment with Aging.

Thorley M, Malatras A, Duddy W, Le Gall L, Mouly V, Butler Browne G, Duguez S.

J Neuromuscul Dis. 2015 Sep 2;2(3):205-217.


Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia.

Duddy W, Duguez S, Johnston H, Cohen TV, Phadke A, Gordish-Dressman H, Nagaraju K, Gnocchi V, Low S, Partridge T.

Skelet Muscle. 2015 May 1;5:16. doi: 10.1186/s13395-015-0041-y. eCollection 2015.


CellWhere: graphical display of interaction networks organized on subcellular localizations.

Zhu L, Malatras A, Thorley M, Aghoghogbe I, Mer A, Duguez S, Butler-Browne G, Voit T, Duddy W.

Nucleic Acids Res. 2015 Jul 1;43(W1):W571-5. doi: 10.1093/nar/gkv354. Epub 2015 Apr 16.


In silico screening based on predictive algorithms as a design tool for exon skipping oligonucleotides in Duchenne muscular dystrophy.

Echigoya Y, Mouly V, Garcia L, Yokota T, Duddy W.

PLoS One. 2015 Mar 27;10(3):e0120058. doi: 10.1371/journal.pone.0120058. eCollection 2015.


Dystrophin deficiency leads to disturbance of LAMP1-vesicle-associated protein secretion.

Duguez S, Duddy W, Johnston H, Lainé J, Le Bihan MC, Brown KJ, Bigot A, Hathout Y, Butler-Browne G, Partridge T.

Cell Mol Life Sci. 2013 Jun;70(12):2159-74. doi: 10.1007/s00018-012-1248-2. Epub 2013 Jan 24.


Atmospheric oxygen tension slows myoblast proliferation via mitochondrial activation.

Duguez S, Duddy WJ, Gnocchi V, Bowe J, Dadgar S, Partridge TA.

PLoS One. 2012;7(8):e43853. doi: 10.1371/journal.pone.0043853. Epub 2012 Aug 24.


Activation of Notch signaling during ex vivo expansion maintains donor muscle cell engraftment.

Parker MH, Loretz C, Tyler AE, Duddy WJ, Hall JK, Olwin BB, Bernstein ID, Storb R, Tapscott SJ.

Stem Cells. 2012 Oct;30(10):2212-20. doi: 10.1002/stem.1181.


Exon skipping for nonsense mutations in Duchenne muscular dystrophy: too many mutations, too few patients?

Yokota T, Duddy W, Echigoya Y, Kolski H.

Expert Opin Biol Ther. 2012 Sep;12(9):1141-52. doi: 10.1517/14712598.2012.693469. Epub 2012 Jun 1. Review.


The isolated muscle fibre as a model of disuse atrophy: characterization using PhAct, a method to quantify f-actin.

Duddy WJ, Cohen T, Duguez S, Partridge TA.

Exp Cell Res. 2011 Aug 15;317(14):1979-93. doi: 10.1016/j.yexcr.2011.05.013. Epub 2011 May 20.

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