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Items: 1 to 20 of 53


Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma.

Nair P, Wenzel S, Rabe KF, Bourdin A, Lugogo NL, Kuna P, Barker P, Sproule S, Ponnarambil S, Goldman M; ZONDA Trial Investigators.

N Engl J Med. 2017 Jun 22;376(25):2448-2458. doi: 10.1056/NEJMoa1703501. Epub 2017 May 22.


The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience.

Russell JA, Lee T, Singer J, Boyd JH, Walley KR; Vasopressin and Septic Shock Trial (VASST) Group.

Crit Care Med. 2017 Jun;45(6):940-948. doi: 10.1097/CCM.0000000000002323.


Urban particulate matter increases human airway epithelial cell IL-1β secretion following scratch wounding and H1N1 influenza A exposure in vitro.

Hirota JA, Marchant DJ, Singhera GK, Moheimani F, Dorscheid DR, Carlsten C, Sin D, Knight D.

Exp Lung Res. 2015;41(6):353-62. doi: 10.3109/01902148.2015.1040528. Epub 2015 Jul 7.


Ovalbumin sensitization of guinea pig at birth prevents the ontogenetic decrease in airway smooth muscle responsiveness.

Chitano P, Wang L, Degan S, Worthington CL, Pozzato V, Hussaini SH, Turner WC, Dorscheid DR, Murphy TM.

Physiol Rep. 2014 Dec 11;2(12). pii: e12241. doi: 10.14814/phy2.12241. Print 2014 Dec 1.


Fluticasone Induces Epithelial Injury and Alters Barrier Function in Normal Subjects.

MacRedmond RE, Singhera GK, Wadsworth SJ, Attridge S, Bahzad M, Williams K, Coxson HO, White SR, Dorscheid DR.

J Steroids Horm Sci. 2014 Jun 11;5(2). pii: 26351.


Estradiol increases mucus synthesis in bronchial epithelial cells.

Tam A, Wadsworth S, Dorscheid D, Man SF, Sin DD.

PLoS One. 2014 Jun 25;9(6):e100633. doi: 10.1371/journal.pone.0100633. eCollection 2014.


Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine.

Mehta S, Granton J, Gordon AC, Cook DJ, Lapinsky S, Newton G, Bandayrel K, Little A, Siau C, Ayers D, Singer J, Lee TC, Walley KR, Storms M, Cooper DJ, Holmes CL, Hebert P, Presneill J, Russell JA; Vasopressin and Septic Shock Trial (VASST) Investigators.

Crit Care. 2013 Jun 20;17(3):R117. doi: 10.1186/cc12789. Erratum in: Crit Care. 2017 May 4;21(1):98.


High-frequency oscillation in early acute respiratory distress syndrome.

Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO; OSCILLATE Trial Investigators; Canadian Critical Care Trials Group.

N Engl J Med. 2013 Feb 28;368(9):795-805. doi: 10.1056/NEJMoa1215554. Epub 2013 Jan 22.


Formation of a stable mimic of ambient particulate matter containing viable infectious respiratory syncytial virus and its dry-deposition directly onto cell cultures.

Cruz-Sanchez TM, Haddrell AE, Hackett TL, Singhera GK, Marchant D, Lekivetz R, Meredith A, Horne D, Knight DA, van Eeden SF, Bai TR, Hegele RG, Dorscheid DR, Agnes GR.

Anal Chem. 2013 Jan 15;85(2):898-906. doi: 10.1021/ac302174y. Epub 2012 Dec 19.


Agreement in electrocardiogram interpretation in patients with septic shock.

Mehta S, Granton J, Lapinsky SE, Newton G, Bandayrel K, Little A, Siau C, Cook DJ, Ayers D, Singer J, Lee TC, Walley KR, Storms M, Cooper J, Holmes CL, Hebert P, Gordon AC, Presneill J, Russell JA; Vasopressin and Septic Shock Trial (VASST) Investigators.

Crit Care Med. 2011 Sep;39(9):2080-6. doi: 10.1097/CCM.0b013e318222720e.


Wound-induced TGF-β1 and TGF-β2 enhance airway epithelial repair via HB-EGF and TGF-α.

Ito J, Harada N, Nagashima O, Makino F, Usui Y, Yagita H, Okumura K, Dorscheid DR, Atsuta R, Akiba H, Takahashi K.

Biochem Biophys Res Commun. 2011 Aug 19;412(1):109-14. doi: 10.1016/j.bbrc.2011.07.054. Epub 2011 Jul 23.


Clinical update on the use of biomarkers of airway inflammation in the management of asthma.

Wadsworth S, Sin D, Dorscheid D.

J Asthma Allergy. 2011;4:77-86. doi: 10.2147/JAA.S15081. Epub 2011 Jun 30.


Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution.

Hackett TL, Singhera GK, Shaheen F, Hayden P, Jackson GR, Hegele RG, Van Eeden S, Bai TR, Dorscheid DR, Knight DA.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):1090-100. doi: 10.1165/rcmb.2011-0031OC. Epub 2011 Jun 3.


The role of female hormones on lung function in chronic lung diseases.

Tam A, Morrish D, Wadsworth S, Dorscheid D, Man SF, Sin DD.

BMC Womens Health. 2011 Jun 3;11:24. doi: 10.1186/1472-6874-11-24. Review.


Conjugated linoleic acid (CLA): is it time to supplement asthma therapy?

Macredmond R, Dorscheid DR.

Pulm Pharmacol Ther. 2011 Oct;24(5):540-8. doi: 10.1016/j.pupt.2011.03.005. Epub 2011 Apr 21. Review.


The airway epithelium: more than just a structural barrier.

Tam A, Wadsworth S, Dorscheid D, Man SF, Sin DD.

Ther Adv Respir Dis. 2011 Aug;5(4):255-73. doi: 10.1177/1753465810396539. Epub 2011 Mar 3. Review.


Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism.

Marchant D, Singhera GK, Utokaparch S, Hackett TL, Boyd JH, Luo Z, Si X, Dorscheid DR, McManus BM, Hegele RG.

J Virol. 2010 Nov;84(21):11359-73. doi: 10.1128/JVI.00804-10. Epub 2010 Aug 11.


Conjugated linoleic acid improves airway hyper-reactivity in overweight mild asthmatics.

MacRedmond R, Singhera G, Attridge S, Bahzad M, Fava C, Lai Y, Hallstrand TS, Dorscheid DR.

Clin Exp Allergy. 2010 Jul;40(7):1071-8. doi: 10.1111/j.1365-2222.2010.03531.x.


IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells.

Wadsworth SJ, Atsuta R, McIntyre JO, Hackett TL, Singhera GK, Dorscheid DR.

J Allergy Clin Immunol. 2010 Aug;126(2):366-74, 374.e1-8. doi: 10.1016/j.jaci.2010.05.015. Epub 2010 Jul 10.


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