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Items: 5


A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.

Vuong BQ, Herrick-Reynolds K, Vaidyanathan B, Pucella JN, Ucher AJ, Donghia NM, Gu X, Nicolas L, Nowak U, Rahman N, Strout MP, Mills KD, Stavnezer J, Chaudhuri J.

Nat Immunol. 2013 Nov;14(11):1183-1189. doi: 10.1038/ni.2732. Epub 2013 Oct 6.


Attenuating homologous recombination stimulates an AID-induced antileukemic effect.

Lamont KR, Hasham MG, Donghia NM, Branca J, Chavaree M, Chase B, Breggia A, Hedlund J, Emery I, Cavallo F, Jasin M, RĂ¼ter J, Mills KD.

J Exp Med. 2013 May 6;210(5):1021-33.


Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.

Hasham MG, Snow KJ, Donghia NM, Branca JA, Lessard MD, Stavnezer J, Shopland LS, Mills KD.

J Immunol. 2012 Sep 1;189(5):2374-82. doi: 10.4049/jimmunol.1200414. Epub 2012 Jul 23.


ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cells.

Maas SA, Donghia NM, Tompkins K, Foreman O, Mills KD.

BMC Biol. 2010 Oct 27;8:132. doi: 10.1186/1741-7007-8-132.


Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination.

Hasham MG, Donghia NM, Coffey E, Maynard J, Snow KJ, Ames J, Wilpan RY, He Y, King BL, Mills KD.

Nat Immunol. 2010 Sep;11(9):820-6. doi: 10.1038/ni.1909. Epub 2010 Jul 25.

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