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Items: 1 to 20 of 103


A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes.

Foglizzo M, Middleton AJ, Burgess AE, Crowther JM, Dobson RCJ, Murphy JM, Day CL, Mace PD.

Nat Commun. 2018 Sep 26;9(1):3932. doi: 10.1038/s41467-018-06186-1.


The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity.

North RA, Wahlgren WY, Remus DM, Scalise M, Kessans SA, Dunevall E, Claesson E, Soares da Costa TP, Perugini MA, Ramaswamy S, Allison JR, Indiveri C, Friemann R, Dobson RCJ.

Front Chem. 2018 Jul 4;6:233. doi: 10.3389/fchem.2018.00233. eCollection 2018.


Crystal structures and kinetic analyses of N-acetylmannosamine-6-phosphate 2-epimerases from Fusobacterium nucleatum and Vibrio cholerae.

Manjunath L, Guntupalli SR, Currie MJ, North RA, Dobson RCJ, Nayak V, Subramanian R.

Acta Crystallogr F Struct Biol Commun. 2018 Jul 1;74(Pt 7):431-440. doi: 10.1107/S2053230X18008543. Epub 2018 Jun 28.


Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target.

Atkinson SC, Dogovski C, Wood K, Griffin MDW, Gorman MA, Hor L, Reboul CF, Buckle AM, Wuttke J, Parker MW, Dobson RCJ, Perugini MA.

Structure. 2018 Jul 3;26(7):948-959.e5. doi: 10.1016/j.str.2018.04.014. Epub 2018 May 24.


Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.

Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R.

Nat Commun. 2018 May 1;9(1):1753. doi: 10.1038/s41467-018-04045-7.


A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals.

Parthasarathy A, Cross PJ, Dobson RCJ, Adams LE, Savka MA, Hudson AO.

Front Mol Biosci. 2018 Apr 6;5:29. doi: 10.3389/fmolb.2018.00029. eCollection 2018. Review.


The self-association and thermal denaturation of caprine and bovine β-lactoglobulin.

Crowther JM, Allison JR, Smolenski GA, Hodgkinson AJ, Jameson GB, Dobson RCJ.

Eur Biophys J. 2018 Oct;47(7):739-750. doi: 10.1007/s00249-018-1300-8. Epub 2018 Apr 16.


Potential for Bacteriophage Endolysins to Supplement or Replace Antibiotics in Food Production and Clinical Care.

Love MJ, Bhandari D, Dobson RCJ, Billington C.

Antibiotics (Basel). 2018 Feb 27;7(1). pii: E17. doi: 10.3390/antibiotics7010017. Review.


"Just a spoonful of sugar...": import of sialic acid across bacterial cell membranes.

North RA, Horne CR, Davies JS, Remus DM, Muscroft-Taylor AC, Goyal P, Wahlgren WY, Ramaswamy S, Friemann R, Dobson RCJ.

Biophys Rev. 2018 Apr;10(2):219-227. doi: 10.1007/s12551-017-0343-x. Epub 2017 Dec 8. Review.


Effects of Beneficial Mutations in pykF Gene Vary over Time and across Replicate Populations in a Long-Term Experiment with Bacteria.

Peng F, Widmann S, Wünsche A, Duan K, Donovan KA, Dobson RCJ, Lenski RE, Cooper TF.

Mol Biol Evol. 2018 Jan 1;35(1):202-210. doi: 10.1093/molbev/msx279.


Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides.

Kavianinia I, Yang SH, Kaur H, Harris PWR, Dobson RCJ, Fairbanks AJ, Brimble MA.

Chem Commun (Camb). 2017 Jul 25;53(60):8459-8462. doi: 10.1039/c7cc05025a.


Structural and functional analysis of the GABARAP interaction motif (GIM).

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG.

EMBO Rep. 2017 Aug;18(8):1382-1396. doi: 10.15252/embr.201643587. Epub 2017 Jun 27.


Dihydrodipicolinate Synthase: Structure, Dynamics, Function, and Evolution.

Grant Pearce F, Hudson AO, Loomes K, Dobson RCJ.

Subcell Biochem. 2017;83:271-289. doi: 10.1007/978-3-319-46503-6_10.


Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus.

North RA, Watson AJ, Pearce FG, Muscroft-Taylor AC, Friemann R, Fairbanks AJ, Dobson RC.

FEBS Lett. 2016 Dec;590(23):4414-4428. doi: 10.1002/1873-3468.12462. Epub 2016 Nov 7.


The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 Å resolution.

Cala AR, Nadeau MT, Abendroth J, Staker BL, Reers AR, Weatherhead AW, Dobson RC, Myler PJ, Hudson AO.

Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):885-891. Epub 2016 Nov 25.


The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia.

Blunt MD, Koehrer S, Dobson RC, Larrayoz M, Wilmore S, Hayman A, Parnell J, Smith LD, Davies A, Johnson PWM, Conley PB, Pandey A, Strefford JC, Stevenson FK, Packham G, Forconi F, Coffey GP, Burger JA, Steele AJ.

Clin Cancer Res. 2017 May 1;23(9):2313-2324. doi: 10.1158/1078-0432.CCR-16-1662. Epub 2016 Oct 3.


Avoidance of stochastic RNA interactions can be harnessed to control protein expression levels in bacteria and archaea.

Umu SU, Poole AM, Dobson RC, Gardner PP.

Elife. 2016 Sep 20;5. pii: e13479. doi: 10.7554/eLife.13479.


Inhibition of Arabidopsis growth by the allelopathic compound azetidine-2-carboxylate is due to the low amino acid specificity of cytosolic prolyl-tRNA synthetase.

Lee J, Joshi N, Pasini R, Dobson RC, Allison J, Leustek T.

Plant J. 2016 Oct;88(2):236-246. doi: 10.1111/tpj.13246. Epub 2016 Aug 31.


The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain.

Chen K, Dobson RC, Lucet IS, Young SN, Pearce FG, Blewitt ME, Murphy JM.

Biochem J. 2016 Jun 15;473(12):1733-44. doi: 10.1042/BCJ20160189. Epub 2016 Apr 8.


Grappling with anisotropic data, pseudo-merohedral twinning and pseudo-translational noncrystallographic symmetry: a case study involving pyruvate kinase.

Donovan KA, Atkinson SC, Kessans SA, Peng F, Cooper TF, Griffin MD, Jameson GB, Dobson RC.

Acta Crystallogr D Struct Biol. 2016 Apr;72(Pt 4):512-9. doi: 10.1107/S205979831600142X. Epub 2016 Mar 24.


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