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Items: 1 to 20 of 77


Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.

Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD.

Cell Metab. 2019 Dec 3;30(6):1024-1039.e6. doi: 10.1016/j.cmet.2019.10.006. Epub 2019 Nov 14.


Ketogenic diet activates protective γδ T cell responses against influenza virus infection.

Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A.

Sci Immunol. 2019 Nov 15;4(41). pii: eaav2026. doi: 10.1126/sciimmunol.aav2026.


Bone Marrow: An Immunometabolic Refuge during Energy Depletion.

Goldberg EL, Dixit VD.

Cell Metab. 2019 Oct 1;30(4):621-623. doi: 10.1016/j.cmet.2019.08.022.


Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.

Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI.

J Physiol. 2019 Aug;597(15):3885-3903. doi: 10.1113/JP277270. Epub 2019 Jul 4.


Gaining Weight: Insulin-Eating Islet Macrophages.

Spadaro O, Dixit VD.

Immunity. 2019 Jan 15;50(1):13-15. doi: 10.1016/j.immuni.2018.12.026.


Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.

Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD.

Cell Rep. 2018 Jul 31;24(5):1085-1092.e6. doi: 10.1016/j.celrep.2018.06.112.


Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.

Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9172-E9180. doi: 10.1073/pnas.1707797114. Epub 2017 Oct 10.


Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.

Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD.

Nature. 2017 Oct 5;550(7674):119-123. doi: 10.1038/nature24022. Epub 2017 Sep 27.


Energy Sparing Orexigenic Inflammation of Obesity.

Lee A, Dixit VD.

Cell Metab. 2017 Jul 5;26(1):10-12. doi: 10.1016/j.cmet.2017.06.013.


IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge.

Spadaro O, Camell CD, Bosurgi L, Nguyen KY, Youm YH, Rothlin CV, Dixit VD.

Cell Rep. 2017 Apr 11;19(2):225-234. doi: 10.1016/j.celrep.2017.03.046.


β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares.

Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD.

Cell Rep. 2017 Feb 28;18(9):2077-2087. doi: 10.1016/j.celrep.2017.02.004.


Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation.

Goldberg EL, Dixit VD.

Mol Metab. 2017 Jan 3;6(2):219-225. doi: 10.1016/j.molmet.2016.12.008. eCollection 2017 Feb.


Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.

Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L.

Aging (Albany NY). 2016 Jul;8(7):1416-31. doi: 10.18632/aging.100994.


Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.

Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD.

Cell Rep. 2016 Feb 23;14(7):1571-1580. doi: 10.1016/j.celrep.2016.01.044. Epub 2016 Feb 11.


Regulation of Nlrp3 inflammasome by dietary metabolites.

Camell C, Goldberg E, Dixit VD.

Semin Immunol. 2015 Sep;27(5):334-42. Review.


Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.

Youm YH, Horvath TL, Mangelsdorf DJ, Kliewer SA, Dixit VD.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1026-31. doi: 10.1073/pnas.1514511113. Epub 2016 Jan 11.


A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents.

Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S.

Diabetes. 2016 Mar;65(3):610-8. doi: 10.2337/db15-1478. Epub 2015 Dec 30.


Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity.

Camell CD, Nguyen KY, Jurczak MJ, Christian BE, Shulman GI, Shadel GS, Dixit VD.

J Biol Chem. 2015 Dec 4;290(49):29402-13. doi: 10.1074/jbc.M115.680199. Epub 2015 Oct 5.


Editorial: "Crowning" eosinophils in adipose tissue: does location matter?

Goldberg EL, Dixit VD.

J Leukoc Biol. 2015 Oct;98(4):451-2. doi: 10.1189/jlb.3CE0415-178RR. No abstract available.


Drivers of age-related inflammation and strategies for healthspan extension.

Goldberg EL, Dixit VD.

Immunol Rev. 2015 May;265(1):63-74. doi: 10.1111/imr.12295. Review.

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