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Items: 1 to 20 of 118

1.

Computational Investigation of RNA A-Bulges Related to Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism.

Wales DJ, Disney MD, Yildirim I.

J Phys Chem B. 2018 Dec 5. doi: 10.1021/acs.jpcb.8b09139. [Epub ahead of print]

PMID:
30517788
2.

The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules.

Wang ZF, Ursu A, Childs-Disney JL, Guertler R, Yang WY, Bernat V, Rzuczek SG, Fuerst R, Zhang YJ, Gendron TF, Yildirim I, Dwyer BG, Rice JE, Petrucelli L, Disney MD.

Cell Chem Biol. 2018 Nov 29. pii: S2451-9456(18)30378-7. doi: 10.1016/j.chembiol.2018.10.018. [Epub ahead of print]

PMID:
30503283
3.

Introduction to the Symposium In Print for Laura Kiessling.

Disney MD.

Bioorg Med Chem. 2018 Oct 15;26(19):iii. doi: 10.1016/j.bmc.2018.10.021. No abstract available.

PMID:
30420097
4.

Drugging the RNA World.

Disney MD, Dwyer BG, Childs-Disney JL.

Cold Spring Harb Perspect Biol. 2018 Nov 1;10(11). pii: a034769. doi: 10.1101/cshperspect.a034769. Review.

PMID:
30385607
5.

Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype.

Li Y, Disney MD.

ACS Chem Biol. 2018 Nov 16;13(11):3065-3071. doi: 10.1021/acschembio.8b00827. Epub 2018 Oct 30.

PMID:
30375843
6.

Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs.

Velagapudi SP, Costales MG, Vummidi BR, Nakai Y, Angelbello AJ, Tran T, Haniff HS, Matsumoto Y, Wang ZF, Chatterjee AK, Childs-Disney JL, Disney MD.

Cell Chem Biol. 2018 Sep 20;25(9):1086-1094.e7. doi: 10.1016/j.chembiol.2018.05.015. Epub 2018 Jun 28.

PMID:
30251629
7.

Introduction.

Disney MD, Janda KD.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2661-2662. doi: 10.1016/j.bmcl.2018.07.013. Epub 2018 Jul 10. No abstract available.

PMID:
30029841
8.

Selective Small Molecule Recognition of RNA Base Pairs.

Haniff HS, Graves A, Disney MD.

ACS Comb Sci. 2018 Aug 13;20(8):482-491. doi: 10.1021/acscombsci.8b00049. Epub 2018 Jul 31.

PMID:
29966095
9.

Small Molecule Targeted Recruitment of a Nuclease to RNA.

Costales MG, Matsumoto Y, Velagapudi SP, Disney MD.

J Am Chem Soc. 2018 Jun 6;140(22):6741-6744. doi: 10.1021/jacs.8b01233. Epub 2018 May 24.

PMID:
29792692
10.

Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.

Angelbello AJ, Chen JL, Childs-Disney JL, Zhang P, Wang ZF, Disney MD.

Chem Rev. 2018 Feb 28;118(4):1599-1663. doi: 10.1021/acs.chemrev.7b00504. Epub 2018 Jan 11.

PMID:
29322778
11.

Bleomycin Can Cleave an Oncogenic Noncoding RNA.

Angelbello AJ, Disney MD.

Chembiochem. 2018 Jan 4;19(1):43-47. doi: 10.1002/cbic.201700581. Epub 2017 Nov 22.

PMID:
29084369
12.

Small molecule alteration of RNA sequence in cells and animals.

Guan L, Luo Y, Ja WW, Disney MD.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2794-2796. doi: 10.1016/j.bmcl.2017.10.034. Epub 2017 Oct 18.

PMID:
29079470
13.

Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.

Chen JL, VanEtten DM, Fountain MA, Yildirim I, Disney MD.

Biochemistry. 2017 Jul 11;56(27):3463-3474. doi: 10.1021/acs.biochem.7b00252. Epub 2017 Jun 29.

14.

Inhibiting Translation One Protein at a Time.

Disney MD.

Trends Biochem Sci. 2017 Jun;42(6):412-413. doi: 10.1016/j.tibs.2017.04.008. Epub 2017 May 15.

PMID:
28522328
15.

Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA.

Velagapudi SP, Luo Y, Tran T, Haniff HS, Nakai Y, Fallahi M, Martinez GJ, Childs-Disney JL, Disney MD.

ACS Cent Sci. 2017 Mar 22;3(3):205-216. doi: 10.1021/acscentsci.7b00009. Epub 2017 Mar 6.

16.

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis.

Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, Tabassian LJ, Lee CW, Yue M, Tong J, Song Y, Castanedes-Casey M, Rousseau L, Phillips V, Dickson DW, Rademakers R, Fryer JD, Rush BK, Pedraza O, Caputo AM, Desaro P, Palmucci C, Robertson A, Heckman MG, Diehl NN, Wiggs E, Tierney M, Braun L, Farren J, Lacomis D, Ladha S, Fournier CN, McCluskey LF, Elman LB, Toledo JB, McBride JD, Tiloca C, Morelli C, Poletti B, Solca F, Prelle A, Wuu J, Jockel-Balsarotti J, Rigo F, Ambrose C, Datta A, Yang W, Raitcheva D, Antognetti G, McCampbell A, Van Swieten JC, Miller BL, Boxer AL, Brown RH, Bowser R, Miller TM, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Traynor BJ, Disney MD, Benatar M, Silani V, Glass JD, Floeter MK, Rothstein JD, Boylan KB, Petrucelli L.

Sci Transl Med. 2017 Mar 29;9(383). pii: eaai7866. doi: 10.1126/scitranslmed.aai7866.

17.

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.

Costales MG, Haga CL, Velagapudi SP, Childs-Disney JL, Phinney DG, Disney MD.

J Am Chem Soc. 2017 Mar 8;139(9):3446-3455. doi: 10.1021/jacs.6b11273. Epub 2017 Feb 27.

18.

Rational Design of Small Molecules Targeting Oncogenic Noncoding RNAs from Sequence.

Disney MD, Angelbello AJ.

Acc Chem Res. 2016 Dec 20;49(12):2698-2704. Epub 2016 Nov 22.

19.

Precise small-molecule recognition of a toxic CUG RNA repeat expansion.

Rzuczek SG, Colgan LA, Nakai Y, Cameron MD, Furling D, Yasuda R, Disney MD.

Nat Chem Biol. 2017 Feb;13(2):188-193. doi: 10.1038/nchembio.2251. Epub 2016 Dec 12.

20.

Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods.

Haga CL, Velagapudi SP, Childs-Disney JL, Strivelli J, Disney MD, Phinney DG.

Methods Mol Biol. 2017;1517:179-198.

PMID:
27924483

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