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Did you mean director of gene therapy and biotherapy (571 results)?
Emerging therapies for glioblastoma: current state and future directions.
Rong L, Li N, Zhang Z. Rong L, et al. J Exp Clin Cancer Res. 2022 Apr 15;41(1):142. doi: 10.1186/s13046-022-02349-7. J Exp Clin Cancer Res. 2022. PMID: 35428347 Free PMC article. Review.
Advances in decades of investment in basic science of glioblastoma are rapidly translated into innovative clinical trials, utilizing improved genetic and epigenetic profiling of glioblastoma as well as the brain microenvironment and immune system interactions. Following th …
Advances in decades of investment in basic science of glioblastoma are rapidly translated into innovative clinical trials, utilizing improve …
Oncolytic virus immunotherapy: future prospects for oncology.
Raja J, Ludwig JM, Gettinger SN, Schalper KA, Kim HS. Raja J, et al. J Immunother Cancer. 2018 Dec 4;6(1):140. doi: 10.1186/s40425-018-0458-z. J Immunother Cancer. 2018. PMID: 30514385 Free PMC article. Review.
Various novel therapies have targeted all three layers of tumor biology: tumor, niche, and immune system with a range of promising results. One emerging class in both primary and salvage therapy is oncolytic viruses. This therapy offers a multimodal approach to spec …
Various novel therapies have targeted all three layers of tumor biology: tumor, niche, and immune system with a range of promising results. …
Targeting strategies of adenovirus-mediated gene therapy and virotherapy for prostate cancer (Review).
Cai Z, Lv H, Cao W, Zhou C, Liu Q, Li H, Zhou F. Cai Z, et al. Mol Med Rep. 2017 Nov;16(5):6443-6458. doi: 10.3892/mmr.2017.7487. Epub 2017 Sep 13. Mol Med Rep. 2017. PMID: 28901490 Free PMC article. Review.
Additionally, there is a lack of effective therapies for PCa at advanced stages. Novel treatment strategies such as adenovirus-mediated gene therapy and virotherapy involve the expression of a specific therapeutic gene to induce death in cancer cells, …
Additionally, there is a lack of effective therapies for PCa at advanced stages. Novel treatment strategies such as adenovirus-mediated g …
Oncolytic virotherapy: basic principles, recent advances and future directions.
Lin D, Shen Y, Liang T. Lin D, et al. Signal Transduct Target Ther. 2023 Apr 11;8(1):156. doi: 10.1038/s41392-023-01407-6. Signal Transduct Target Ther. 2023. PMID: 37041165 Free PMC article. Review.
Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they are generally considered to have direct oncolysis and cancer immune effects. With the progress in genetic engineering technology, OVs have been adopted as versatile platfor …
Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they are generally considered to have direct …
Oncolytic Virotherapy Treatment of Breast Cancer: Barriers and Recent Advances.
Kwan A, Winder N, Muthana M. Kwan A, et al. Viruses. 2021 Jun 11;13(6):1128. doi: 10.3390/v13061128. Viruses. 2021. PMID: 34208264 Free PMC article. Review.
Oncolytic virotherapy (OV) is an emerging class of immunotherapeutic drugs. Their mechanism of action is two-fold: direct cell lysis and unmasking of the cancer through immunogenic cell death, which allows the immune system to recognize and eradicate tumours. ...Thi …
Oncolytic virotherapy (OV) is an emerging class of immunotherapeutic drugs. Their mechanism of action is two-fold: direct cell …
Tropism and transduction of oncolytic adenovirus vectors in prostate cancer therapy.
Wu C, Wei FK, Xu ZY, Wen RM, Chen JC, Wang JQ, Mao LJ. Wu C, et al. Front Biosci (Landmark Ed). 2021 Oct 30;26(10):866-872. doi: 10.52586/4993. Front Biosci (Landmark Ed). 2021. PMID: 34719211 Free article. Review.
Nevertheless, there are still big challenges for translational research of oncolytic virotherapy in clinical cancer management. Therefore, here we summarize current status on the design and application of oncolytic adenovirus vectors for prostate cancer therapy. In …
Nevertheless, there are still big challenges for translational research of oncolytic virotherapy in clinical cancer management. There …
VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects.
Bazan-Peregrino M, Garcia-Carbonero R, Laquente B, Álvarez R, Mato-Berciano A, Gimenez-Alejandre M, Morgado S, Rodríguez-García A, Maliandi MV, Riesco MC, Moreno R, Ginestà MM, Perez-Carreras M, Gornals JB, Prados S, Perea S, Capella G, Alemany R, Salazar R, Blasi E, Blasco C, Cascallo M, Hidalgo M. Bazan-Peregrino M, et al. J Immunother Cancer. 2021 Nov;9(11):e003254. doi: 10.1136/jitc-2021-003254. J Immunother Cancer. 2021. PMID: 35149591 Free PMC article. Clinical Trial.
Patients had increasing levels of hyaluronidase in sera over time and decreased tumor stiffness, suggesting stromal disruption. CONCLUSIONS: VCN-01 is an oncolytic adenovirus with direct antitumor effects and stromal disruption capabilities, representing a new therapeutic …
Patients had increasing levels of hyaluronidase in sera over time and decreased tumor stiffness, suggesting stromal disruption. CONCLUSIONS: …
Combined cytotoxic and immune-stimulatory gene therapy using Ad-TK and Ad-Flt3L: Translational developments from rodents to glioma patients.
Faisal SM, Castro MG, Lowenstein PR. Faisal SM, et al. Mol Ther. 2023 Oct 4;31(10):2839-2860. doi: 10.1016/j.ymthe.2023.08.009. Epub 2023 Aug 12. Mol Ther. 2023. PMID: 37574780 Free article. Review.
The poor prognosis of glioma patients, resistance to chemo-radiotherapy, and the immunosuppressive tumor microenvironment underscore the need for the development of novel therapies. Gene therapy-based immunotherapeutic strategies that couple the ability of the host …
The poor prognosis of glioma patients, resistance to chemo-radiotherapy, and the immunosuppressive tumor microenvironment underscore the nee …
Sui generis: gene therapy and delivery systems for the treatment of glioblastoma.
Kane JR, Miska J, Young JS, Kanojia D, Kim JW, Lesniak MS. Kane JR, et al. Neuro Oncol. 2015 Mar;17 Suppl 2(Suppl 2):ii24-ii36. doi: 10.1093/neuonc/nou355. Neuro Oncol. 2015. PMID: 25746089 Free PMC article. Review.
Gene therapy offers a multidimensional set of approaches intended to treat and cure glioblastoma (GBM), in combination with the existing standard-of-care treatment (surgery and chemoradiotherapy), by capitalizing on the ability to deliver genes directly to the site …
Gene therapy offers a multidimensional set of approaches intended to treat and cure glioblastoma (GBM), in combination with th …
Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy.
Bressy C, Hastie E, Grdzelishvili VZ. Bressy C, et al. Mol Ther Oncolytics. 2017 Mar 21;5:20-40. doi: 10.1016/j.omto.2017.03.002. eCollection 2017 Jun 16. Mol Ther Oncolytics. 2017. PMID: 28480326 Free PMC article. Review.
Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. ...This review summarizes studies combining p53 gene therapy with replication-competent OV therapy, reviews preclinical and …
Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. ...Th …
303 results