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Tau monomer encodes strains.

Sharma AM, Thomas TL, Woodard DR, Kashmer OM, Diamond MI.

Elife. 2018 Dec 11;7. pii: e37813. doi: 10.7554/eLife.37813.


Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics.

Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Su BW, Song ES, Cairns NJ, Kotzbauer PT, Diamond MI.

J Biol Chem. 2019 Jan 18;294(3):1045-1058. doi: 10.1074/jbc.RA118.004471. Epub 2018 Nov 26.


Rebuttal to Drs. Grinberg and Heinsen.

Kaufman SK, Del Tredici K, Braak H, Diamond MI.

Acta Neuropathol. 2018 Nov;136(5):819. doi: 10.1007/s00401-018-1917-9. Epub 2018 Oct 3. No abstract available.


Inert and seed-competent tau monomers suggest structural origins of aggregation.

Mirbaha H, Chen D, Morazova OA, Ruff KM, Sharma AM, Liu X, Goodarzi M, Pappu RV, Colby DW, Mirzaei H, Joachimiak LA, Diamond MI.

Elife. 2018 Jul 10;7. pii: e36584. doi: 10.7554/eLife.36584.


Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART.

Kaufman SK, Del Tredici K, Thomas TL, Braak H, Diamond MI.

Acta Neuropathol. 2018 Jul;136(1):57-67. doi: 10.1007/s00401-018-1855-6. Epub 2018 May 11.


Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates.

Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI.

J Biol Chem. 2018 Jul 6;293(27):10826-10840. doi: 10.1074/jbc.RA117.000378. Epub 2018 May 11.


Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers.

Posey AE, Ruff KM, Harmon TS, Crick SL, Li A, Diamond MI, Pappu RV.

J Biol Chem. 2018 Mar 9;293(10):3734-3746. doi: 10.1074/jbc.RA117.000357. Epub 2018 Jan 22.


The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.

Eskandari-Sedighi G, Daude N, Gapeshina H, Sanders DW, Kamali-Jamil R, Yang J, Shi B, Wille H, Ghetti B, Diamond MI, Janus C, Westaway D.

Mol Neurodegener. 2017 Oct 4;12(1):72. doi: 10.1186/s13024-017-0215-7.


Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue.

Kaufman SK, Thomas TL, Del Tredici K, Braak H, Diamond MI.

Acta Neuropathol Commun. 2017 Jun 7;5(1):41. doi: 10.1186/s40478-017-0442-8.


Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid.

Saijo E, Ghetti B, Zanusso G, Oblak A, Furman JL, Diamond MI, Kraus A, Caughey B.

Acta Neuropathol. 2017 May;133(5):751-765. doi: 10.1007/s00401-017-1692-z. Epub 2017 Mar 14.


The prion model for progression and diversity of neurodegenerative diseases.

Stopschinski BE, Diamond MI.

Lancet Neurol. 2017 Apr;16(4):323-332. doi: 10.1016/S1474-4422(17)30037-6. Epub 2017 Feb 24. Review.


Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.

DeVos SL, Miller RL, Schoch KM, Holmes BB, Kebodeaux CS, Wegener AJ, Chen G, Shen T, Tran H, Nichols B, Zanardi TA, Kordasiewicz HB, Swayze EE, Bennett CF, Diamond MI, Miller TM.

Sci Transl Med. 2017 Jan 25;9(374). pii: eaag0481. doi: 10.1126/scitranslmed.aag0481.


FRET and Flow Cytometry Assays to Measure Proteopathic Seeding Activity in Biological Samples.

Furman JL, Diamond MI.

Methods Mol Biol. 2017;1523:349-359.


Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.

Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM, Miller TM, Diamond MI.

Neuron. 2016 Nov 23;92(4):796-812. doi: 10.1016/j.neuron.2016.09.055. Epub 2016 Oct 27.


Widespread tau seeding activity at early Braak stages.

Furman JL, Vaquer-Alicea J, White CL 3rd, Cairns NJ, Nelson PT, Diamond MI.

Acta Neuropathol. 2017 Jan;133(1):91-100. doi: 10.1007/s00401-016-1644-z. Epub 2016 Nov 22.


Cellular Models for the Study of Prions.

Holmes BB, Diamond MI.

Cold Spring Harb Perspect Med. 2017 Feb 1;7(2). pii: a024026. doi: 10.1101/cshperspect.a024026. Review.


Neuronal activity enhances tau propagation and tau pathology in vivo.

Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, Sanders DW, Cook C, Fu H, Boonen RA, Herman M, Nahmani E, Emrani S, Figueroa YH, Diamond MI, Clelland CL, Wray S, Duff KE.

Nat Neurosci. 2016 Aug;19(8):1085-92. doi: 10.1038/nn.4328. Epub 2016 Jun 20.


Prions and Protein Assemblies that Convey Biological Information in Health and Disease.

Sanders DW, Kaufman SK, Holmes BB, Diamond MI.

Neuron. 2016 Feb 3;89(3):433-48. doi: 10.1016/j.neuron.2016.01.026. Review.


Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry.

Furman JL, Holmes BB, Diamond MI.

J Vis Exp. 2015 Dec 8;(106):e53205. doi: 10.3791/53205.


Photo-activatable Cre recombinase regulates gene expression in vivo.

Schindler SE, McCall JG, Yan P, Hyrc KL, Li M, Tucker CL, Lee JM, Bruchas MR, Diamond MI.

Sci Rep. 2015 Sep 9;5:13627. doi: 10.1038/srep13627.

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