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Items: 1 to 20 of 57


Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension.

Kapoor R, Ho PR, Campbell N, Chang I, Deykin A, Forrestal F, Lucas N, Yu B, Arnold DL, Freedman MS, Goldman MD, Hartung HP, Havrdová EK, Jeffery D, Miller A, Sellebjerg F, Cadavid D, Mikol D, Steiner D; ASCEND investigators.

Lancet Neurol. 2018 May;17(5):405-415. doi: 10.1016/S1474-4422(18)30069-3. Epub 2018 Mar 12.


[Dimebon delays the onset of symptoms of FUS-proteinopathy in transgenic mice].

Maltsev AV, Deykin AV, Ovchinnikov RK, Chicheva MM, Kovrazhkina EA, Razinskaya OD, Bronovitsky EV, Budevich AI, Kirikovich YK, Bachurin SO, Ustyugov AA, Skvortsova VI.

Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(4):64-67. doi: 10.17116/jnevro20171174164-67. Russian.


Population-Based Pharmacokinetic and Exposure-Efficacy Analyses of Peginterferon Beta-1a in Patients With Relapsing Multiple Sclerosis.

Hu X, Hang Y, Cui Y, Zhang J, Liu S, Seddighzadeh A, Deykin A, Nestorov I.

J Clin Pharmacol. 2017 Aug;57(8):1005-1016. doi: 10.1002/jcph.883. Epub 2017 Apr 10.


Analysis of peginterferon β-1a exposure and Gd-enhanced lesion or T2 lesion response in relapsing-remitting multiple sclerosis patients.

Hang Y, Hu X, Zhang J, Liu S, Deykin A, Nestorov I.

J Pharmacokinet Pharmacodyn. 2016 Aug;43(4):371-83. doi: 10.1007/s10928-016-9477-x. Epub 2016 Jun 14.


Dual A1/A2B Receptor Blockade Improves Cardiac and Renal Outcomes in a Rat Model of Heart Failure with Preserved Ejection Fraction.

Tofovic SP, Salah EM, Smits GJ, Whalley ET, Ticho B, Deykin A, Jackson EK.

J Pharmacol Exp Ther. 2016 Feb;356(2):333-40. doi: 10.1124/jpet.115.228841. Epub 2015 Nov 19.


Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif.

Robinson HK, Deykin AV, Bronovitsky EV, Ovchinnikov RK, Ustyugov AA, Shelkovnikova TA, Kukharsky MS, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Bachurin SO, Buchman VL, Ninkina NN.

Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):402-9. doi: 10.3109/21678421.2015.1040994. Epub 2015 May 20.


Effect of peginterferon beta-1a on MRI measures and achieving no evidence of disease activity: results from a randomized controlled trial in relapsing-remitting multiple sclerosis.

Arnold DL, Calabresi PA, Kieseier BC, Sheikh SI, Deykin A, Zhu Y, Liu S, You X, Sperling B, Hung S.

BMC Neurol. 2014 Dec 31;14:240. doi: 10.1186/s12883-014-0240-x.


Peginterferon beta-1a in multiple sclerosis: 2-year results from ADVANCE.

Kieseier BC, Arnold DL, Balcer LJ, Boyko AA, Pelletier J, Liu S, Zhu Y, Seddighzadeh A, Hung S, Deykin A, Sheikh SI, Calabresi PA.

Mult Scler. 2015 Jul;21(8):1025-35. doi: 10.1177/1352458514557986. Epub 2014 Nov 28.


Pharmacokinetics and pharmacodynamics of peginterferon beta-1a in patients with relapsing-remitting multiple sclerosis in the randomized ADVANCE study.

Hu X, Cui Y, White J, Zhu Y, Deykin A, Nestorov I, Hung S.

Br J Clin Pharmacol. 2015 Mar;79(3):514-22. doi: 10.1111/bcp.12521.


Pegylated interferon β-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study.

Calabresi PA, Kieseier BC, Arnold DL, Balcer LJ, Boyko A, Pelletier J, Liu S, Zhu Y, Seddighzadeh A, Hung S, Deykin A; ADVANCE Study Investigators.

Lancet Neurol. 2014 Jul;13(7):657-65. doi: 10.1016/S1474-4422(14)70068-7. Epub 2014 Apr 30.


Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.

Shelkovnikova TA, Peters OM, Deykin AV, Connor-Robson N, Robinson H, Ustyugov AA, Bachurin SO, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Skvortsova VI, Ling SC, Da Cruz S, Parone PA, Buchman VL, Ninkina NN.

J Biol Chem. 2013 Aug 30;288(35):25266-74. doi: 10.1074/jbc.M113.492017. Epub 2013 Jul 18.


Use of transgenic animals in biotechnology: prospects and problems.

Maksimenko OG, Deykin AV, Khodarovich YM, Georgiev PG.

Acta Naturae. 2013 Jan;5(1):33-46.


Production of human lactoferrin in animal milk.

Goldman IL, Georgieva SG, Gurskiy YG, Krasnov AN, Deykin AV, Popov AN, Ermolkevich TG, Budzevich AI, Chernousov AD, Sadchikova ER.

Biochem Cell Biol. 2012 Jun;90(3):513-9. doi: 10.1139/o11-088. Epub 2012 Feb 23.


A large subgroup of mild-to-moderate asthma is persistently noneosinophilic.

McGrath KW, Icitovic N, Boushey HA, Lazarus SC, Sutherland ER, Chinchilli VM, Fahy JV; Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute.

Am J Respir Crit Care Med. 2012 Mar 15;185(6):612-9. doi: 10.1164/rccm.201109-1640OC. Epub 2012 Jan 20.


An open-label, multicenter study to evaluate the safe and effective use of the single-use autoinjector with an Avonex® prefilled syringe in multiple sclerosis subjects.

Phillips JT, Fox E, Grainger W, Tuccillo D, Liu S, Deykin A.

BMC Neurol. 2011 Oct 14;11:126. doi: 10.1186/1471-2377-11-126.


Dose titration of intramuscular interferon beta-1a reduces the severity and incidence of flu-like symptoms during treatment initiation.

Matson MA, Zimmerman TR Jr, Tuccillo D, Tang Y, Deykin A.

Curr Med Res Opin. 2011 Dec;27(12):2271-8. doi: 10.1185/03007995.2011.630720. Epub 2011 Oct 28.


Pharmacokinetics of oral tonapofylline and its acyl-glucuronide metabolite in patients with mild and moderate hepatic impairment.

Li Z, Gan LS, Marbury T, Lasseter KC, Natarajan A, Stecher S, Wei D, Yang L, Freedman D, Deykin A.

J Clin Pharmacol. 2012 Apr;52(4):543-51. doi: 10.1177/0091270011400413. Epub 2011 May 24.


Effects of BG9928, an adenosine A₁ receptor antagonist, in patients with congestive heart failure.

Gottlieb SS, Ticho B, Deykin A, Abraham WT, Denofrio D, Russell SD, Chapman D, Smith W, Goldman S, Thomas I.

J Clin Pharmacol. 2011 Jun;51(6):899-907. doi: 10.1177/0091270010375957. Epub 2010 Oct 6.


Lip commissure to eyelid transposition for repair of feline eyelid agenesis.

Whittaker CJ, Wilkie DA, Simpson DJ, Deykin A, Smith JS, Robinson CL.

Vet Ophthalmol. 2010 May;13(3):173-8. doi: 10.1111/j.1463-5224.2010.00778.x.


The state of health and the reproductive potential of transgenic mice secreting recombinant human lactoferrin in milk.

Deykin AV, Ermolkevich TG, Gursky YG, Krasnov AN, Georgieva SG, Kuznetsov SL, Derevyanko VG, Novikova NI, Murashev AN, Goldman IL, Sadchikova ER.

Dokl Biochem Biophys. 2009 Jul-Aug;427:195-8. No abstract available.


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