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Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition.

Daga N, Eicher S, Kannan A, Casanova A, Low SH, Kreibich S, Andritschke D, Emmenlauer M, Jenkins JL, Hardt WD, Greber UF, Dehio C, von Mering C.

Nucleic Acids Res. 2018 Oct 12;46(18):9309-9320. doi: 10.1093/nar/gky798.


Improved pathway reconstruction from RNA interference screens by exploiting off-target effects.

Srivatsa S, Kuipers J, Schmich F, Eicher S, Emmenlauer M, Dehio C, Beerenwinkel N.

Bioinformatics. 2018 Jul 1;34(13):i519-i527. doi: 10.1093/bioinformatics/bty240.


Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria.

Lobet E, Willemart K, Ninane N, Demazy C, Sedzicki J, Lelubre C, De Bolle X, Renard P, Raes M, Dehio C, Letesson JJ, Arnould T.

Sci Rep. 2018 Mar 26;8(1):5173. doi: 10.1038/s41598-018-23483-3.


3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum.

Sedzicki J, Tschon T, Low SH, Willemart K, Goldie KN, Letesson JJ, Stahlberg H, Dehio C.

J Cell Sci. 2018 Feb 22;131(4). pii: jcs210799. doi: 10.1242/jcs.210799.


Editorial overview: Bacterial systems biology.

Dehio C, Bumann D.

Curr Opin Microbiol. 2017 Oct;39:viii-xi. doi: 10.1016/j.mib.2017.11.024. No abstract available.


An integrative strategy to identify the entire protein coding potential of prokaryotic genomes by proteogenomics.

Omasits U, Varadarajan AR, Schmid M, Goetze S, Melidis D, Bourqui M, Nikolayeva O, Québatte M, Patrignani A, Dehio C, Frey JE, Robinson MD, Wollscheid B, Ahrens CH.

Genome Res. 2017 Dec;27(12):2083-2095. doi: 10.1101/gr.218255.116. Epub 2017 Nov 15.


A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella.

Harms A, Liesch M, Körner J, Québatte M, Engel P, Dehio C.

PLoS Genet. 2017 Oct 26;13(10):e1007077. doi: 10.1371/journal.pgen.1007077. eCollection 2017 Oct.


Systems-level interference strategies to decipher host factors involved in bacterial pathogen interaction: from RNAi to CRISPRi.

Québatte M, Dehio C.

Curr Opin Microbiol. 2017 Oct;39:34-41. doi: 10.1016/j.mib.2017.08.002. Epub 2017 Sep 1. Review.


Gene Transfer Agent Promotes Evolvability within the Fittest Subpopulation of a Bacterial Pathogen.

Québatte M, Christen M, Harms A, Körner J, Christen B, Dehio C.

Cell Syst. 2017 Jun 28;4(6):611-621.e6. doi: 10.1016/j.cels.2017.05.011. Epub 2017 Jun 14.


The Conjugative Relaxase TrwC Promotes Integration of Foreign DNA in the Human Genome.

González-Prieto C, Gabriel R, Dehio C, Schmidt M, Llosa M.

Appl Environ Microbiol. 2017 May 31;83(12). pii: e00207-17. doi: 10.1128/AEM.00207-17. Print 2017 Jun 15.


Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella.

Harms A, Segers FH, Quebatte M, Mistl C, Manfredi P, Körner J, Chomel BB, Kosoy M, Maruyama S, Engel P, Dehio C.

Genome Biol Evol. 2017 Mar 1;9(3):761-776. doi: 10.1093/gbe/evx042.


Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results.

Riba A, Emmenlauer M, Chen A, Sigoillot F, Cong F, Dehio C, Jenkins J, Zavolan M.

Cell Syst. 2017 Feb 22;4(2):182-193.e4. doi: 10.1016/j.cels.2017.01.011. Epub 2017 Feb 15.


Type IV Effector Secretion and Subversion of Host Functions by Bartonella and Brucella Species.

Dehio C, Tsolis RM.

Curr Top Microbiol Immunol. 2017;413:269-295. doi: 10.1007/978-3-319-75241-9_11.


The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook.

Stanger FV, de Beer TAP, Dranow DM, Schirmer T, Phan I, Dehio C.

Structure. 2017 Jan 3;25(1):203-211. doi: 10.1016/j.str.2016.10.010. Epub 2016 Nov 23.


Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin.

Stanger FV, Harms A, Dehio C, Schirmer T.

PLoS One. 2016 Sep 22;11(9):e0163654. doi: 10.1371/journal.pone.0163654. eCollection 2016.


A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion.

Andritschke D, Dilling S, Emmenlauer M, Welz T, Schmich F, Misselwitz B, Rämö P, Rottner K, Kerkhoff E, Wada T, Penninger JM, Beerenwinkel N, Horvath P, Dehio C, Hardt WD.

PLoS One. 2016 Sep 14;11(9):e0161965. doi: 10.1371/journal.pone.0161965. eCollection 2016.


Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells.

Casanova A, Low SH, Emmenlauer M, Conde-Alvarez R, Salcedo SP, Gorvel JP, Dehio C.

J Vis Exp. 2016 Aug 5;(114). doi: 10.3791/54263.


The Affinity of Cholesterol for Different Phospholipids Affects Lateral Segregation in Bilayers.

Engberg O, Hautala V, Yasuda T, Dehio H, Murata M, Slotte JP, Nyholm TKM.

Biophys J. 2016 Aug 9;111(3):546-556. doi: 10.1016/j.bpj.2016.06.036.


Biological Diversity and Molecular Plasticity of FIC Domain Proteins.

Harms A, Stanger FV, Dehio C.

Annu Rev Microbiol. 2016 Sep 8;70:341-60. doi: 10.1146/annurev-micro-102215-095245. Epub 2016 Jul 8. Review.


Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function.

Balmer ML, Ma EH, Bantug GR, Grählert J, Pfister S, Glatter T, Jauch A, Dimeloe S, Slack E, Dehio P, Krzyzaniak MA, King CG, Burgener AV, Fischer M, Develioglu L, Belle R, Recher M, Bonilla WV, Macpherson AJ, Hapfelmeier S, Jones RG, Hess C.

Immunity. 2016 Jun 21;44(6):1312-24. doi: 10.1016/j.immuni.2016.03.016. Epub 2016 May 17.

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