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Sci Transl Med. 2011 Jun 15;3(87):87ps23. doi: 10.1126/scitranslmed.3002695.

Deep sequencing of patient genomes for disease diagnosis: when will it become routine?

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1
National Center for Genome Resources, Santa Fe, NM 87505, USA. sfkingsmore@cmh.edu

Abstract

Next-generation sequencing technologies have greatly lowered the cost of whole-genome sequencing (WGS) and related approaches. Thus, comprehensive sequencing for diagnostic purposes may clear this financial hurdle in the near future. The report by Bainbridge and colleagues in this issue of Science Translational Medicine illustrates the diagnostic power of WGS. In this Perspective, we discuss whether and how genome sequencing might become routine for clinical diagnosis.

PMID:
21677196
PMCID:
PMC4264992
DOI:
10.1126/scitranslmed.3002695
[Indexed for MEDLINE]
Free PMC Article
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