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Items: 1 to 20 of 209

1.

Stat3 in mitosis: A new role in clustering excess centrosomes.

Morris EJ, Dedhar S.

Cell Cycle. 2017;16(17):1557-1559. doi: 10.1080/15384101.2017.1348064. Epub 2017 Aug 7. No abstract available.

2.

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J.

Mol Cell. 2017 Aug 3;67(3):512-527.e4. doi: 10.1016/j.molcel.2017.06.033. Epub 2017 Jul 27.

PMID:
28757207
3.

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.

Swayampakula M, McDonald PC, Vallejo M, Coyaud E, Chafe SC, Westerback A, Venkateswaran G, Shankar J, Gao G, Laurent EMN, Lou Y, Bennewith KL, Supuran CT, Nabi IR, Raught B, Dedhar S.

Oncogene. 2017 Jul 10. doi: 10.1038/onc.2017.219. [Epub ahead of print]

PMID:
28692057
4.

Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.

Morris EJ, Kawamura E, Gillespie JA, Balgi A, Kannan N, Muller WJ, Roberge M, Dedhar S.

Nat Commun. 2017 May 5;8:15289. doi: 10.1038/ncomms15289.

5.

Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.

El Kharbili M, Robert C, Witkowski T, Danty-Berger E, Barbollat-Boutrand L, Masse I, Gadot N, de la Fouchardière A, McDonald PC, Dedhar S, Le Naour F, Degoul F, Berthier-Vergnes O.

Oncotarget. 2017 Mar 7;8(10):17140-17155. doi: 10.18632/oncotarget.15084.

6.

A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells.

Al-Ghabkari A, Deng JT, McDonald PC, Dedhar S, Alshehri M, Walsh MP, MacDonald JA.

Sci Rep. 2016 Aug 30;6:32118. doi: 10.1038/srep32118.

7.

Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction.

McDonald PC, Chafe SC, Dedhar S.

Front Cell Dev Biol. 2016 Mar 31;4:27. doi: 10.3389/fcell.2016.00027. eCollection 2016. Review.

8.

Targeting hypoxic response for cancer therapy.

Paolicchi E, Gemignani F, Krstic-Demonacos M, Dedhar S, Mutti L, Landi S.

Oncotarget. 2016 Mar 22;7(12):13464-78. doi: 10.18632/oncotarget.7229. Review.

9.

Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development.

Chafe SC, Dedhar S.

Oncoimmunology. 2015 Jun 26;4(12):e1048955. eCollection 2015 Dec.

10.

Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression.

Shvab A, Haase G, Ben-Shmuel A, Gavert N, Brabletz T, Dedhar S, Ben-Ze'ev A.

Oncogene. 2016 Feb 4;35(5):549-57. doi: 10.1038/onc.2015.127. Epub 2015 Apr 27.

PMID:
25915847
11.
12.

Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production.

Chafe SC, Lou Y, Sceneay J, Vallejo M, Hamilton MJ, McDonald PC, Bennewith KL, Möller A, Dedhar S.

Cancer Res. 2015 Mar 15;75(6):996-1008. doi: 10.1158/0008-5472.CAN-14-3000. Epub 2015 Jan 26.

13.

Integrin-linked kinase regulates tubular aquaporin-2 content and intracellular location: a link between the extracellular matrix and water reabsorption.

Cano-Peñalver JL, Griera M, Serrano I, Rodríguez-Puyol D, Dedhar S, de Frutos S, Rodríguez-Puyol M.

FASEB J. 2014 Aug;28(8):3645-59. doi: 10.1096/fj.13-249250. Epub 2014 May 1.

14.

LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.

Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KLB, Rauscher FJ 3rd.

Cancer Res. 2014 Mar 1;74(5):1390-1403. doi: 10.1158/0008-5472.CAN-13-1275.

15.

Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.

Teo ZL, McQueen-Miscamble L, Turner K, Martinez G, Madakashira B, Dedhar S, Robinson ML, de Iongh RU.

Exp Eye Res. 2014 Apr;121:130-42. doi: 10.1016/j.exer.2014.01.013. Epub 2014 Jan 25.

PMID:
24472646
16.

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

Serrano I, McDonald PC, Lock F, Muller WJ, Dedhar S.

Nat Commun. 2013;4:2976. doi: 10.1038/ncomms3976.

17.

Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice.

Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A.

Circ Heart Fail. 2014 Jan;7(1):184-93. doi: 10.1161/CIRCHEARTFAILURE.113.000649. Epub 2013 Dec 6.

18.

Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells.

McDonald PC, Dedhar S.

Subcell Biochem. 2014;75:255-69. doi: 10.1007/978-94-007-7359-2_13. Review.

PMID:
24146383
19.

Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization.

El-Hoss J, Arabian A, Dedhar S, St-Arnaud R.

Gene. 2014 Jan 1;533(1):246-52. doi: 10.1016/j.gene.2013.09.074. Epub 2013 Oct 2.

PMID:
24095779
20.

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells.

Kawamura E, Fielding AB, Kannan N, Balgi A, Eaves CJ, Roberge M, Dedhar S.

Oncotarget. 2013 Oct;4(10):1763-76.

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