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Items: 1 to 20 of 271

1.

Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import.

Demeulemeester J, Blokken J, De Houwer S, Dirix L, Klaassen H, Marchand A, Chaltin P, Christ F, Debyser Z.

Retrovirology. 2018 Jan 12;15(1):5. doi: 10.1186/s12977-018-0389-2.

2.

Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting.

Gijsbers R, Vets S, De Rijck J, Ocwieja KE, Ronen K, Malani N, Bushman FD, Debyser Z.

J Biol Chem. 2018 Jan 5;293(1):114. doi: 10.1074/jbc.W117.001458. No abstract available.

3.

Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets.

Blokken J, De Rijck J, Christ F, Debyser Z.

Drug Discov Today Technol. 2017 Jun;24:25-31. doi: 10.1016/j.ddtec.2017.11.002. Epub 2017 Nov 23. Review.

PMID:
29233296
4.

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.

El Ashkar S, Schwaller J, Pieters T, Goossens S, Demeulemeester J, Christ F, Van Belle S, Juge S, Boeckx N, Engelman A, Van Vlierberghe P, Debyser Z, De Rijck J.

Blood. 2018 Jan 4;131(1):95-107. doi: 10.1182/blood-2017-05-786962. Epub 2017 Oct 30.

5.

Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication.

Hofmann S, Dehn S, Businger R, Bolduan S, Schneider M, Debyser Z, Brack-Werner R, Schindler M.

Open Biol. 2017 Oct;7(10). pii: 170115. doi: 10.1098/rsob.170115.

6.

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy.

El Ashkar S, Van Looveren D, Schenk F, Vranckx LS, Demeulemeester J, De Rijck J, Debyser Z, Modlich U, Gijsbers R.

Mol Ther Nucleic Acids. 2017 Jun 16;7:231-245. doi: 10.1016/j.omtn.2017.04.002. Epub 2017 Apr 12.

7.

N-terminal half of transportin SR2 interacts with HIV integrase.

Tsirkone VG, Blokken J, De Wit F, Breemans J, De Houwer S, Debyser Z, Christ F, Strelkov SV.

J Biol Chem. 2017 Jun 9;292(23):9699-9710. doi: 10.1074/jbc.M117.777029. Epub 2017 Mar 29.

8.

Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection.

Saleh S, Vranckx L, Gijsbers R, Christ F, Debyser Z.

J Virus Erad. 2017 Jan 1;3(1):7-14.

9.

Tenofovir prodrugs: similar but not the same.

Bruggemans A, Debyser Z.

Lancet HIV. 2017 May;4(5):e190-e191. doi: 10.1016/S2352-3018(17)30033-4. Epub 2017 Mar 2. No abstract available.

PMID:
28259775
10.

Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry.

Borrenberghs D, Dirix L, De Wit F, Rocha S, Blokken J, De Houwer S, Gijsbers R, Christ F, Hofkens J, Hendrix J, Debyser Z.

Sci Rep. 2016 Nov 10;6:36485. doi: 10.1038/srep36485.

11.

Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras.

Vranckx LS, Demeulemeester J, Debyser Z, Gijsbers R.

PLoS One. 2016 Oct 27;11(10):e0164167. doi: 10.1371/journal.pone.0164167. eCollection 2016.

12.

A novel translational model for fetoscopic intratracheal delivery of nanoparticles in piglets.

Carlon MS, Engels AC, Bosch B, Joyeux L, Mori da Cunha MG, Vidović D, Debyser Z, De Boeck K, Neyrinck A, Deprest JA.

Prenat Diagn. 2016 Oct;36(10):926-934. doi: 10.1002/pd.4915. Epub 2016 Sep 18.

PMID:
27567969
13.

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors.

De Luca L, Agharbaoui FE, Gitto R, Buemi MR, Christ F, Debyser Z, Ferro S.

Mol Inform. 2016 Sep;35(8-9):460-73. doi: 10.1002/minf.201501034. Epub 2016 Jul 25.

PMID:
27546050
14.

LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV.

Vranckx LS, Demeulemeester J, Saleh S, Boll A, Vansant G, Schrijvers R, Weydert C, Battivelli E, Verdin E, Cereseto A, Christ F, Gijsbers R, Debyser Z.

EBioMedicine. 2016 Jun;8:248-264. doi: 10.1016/j.ebiom.2016.04.039. Epub 2016 May 13.

15.

Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia.

Cermakova K, Weydert C, Christ F, De Rijck J, Debyser Z.

Trends Pharmacol Sci. 2016 Aug;37(8):660-671. doi: 10.1016/j.tips.2016.05.005. Epub 2016 Jun 9. Review.

PMID:
27290878
16.

Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates.

Ory D, Celen S, Gijsbers R, Van Den Haute C, Postnov A, Koole M, Vandeputte C, Andrés JI, Alcazar J, De Angelis M, Langlois X, Bhattacharya A, Schmidt M, Letavic MA, Vanduffel W, Van Laere K, Verbruggen A, Debyser Z, Bormans G.

J Nucl Med. 2016 Sep;57(9):1436-41. doi: 10.2967/jnumed.115.169995. Epub 2016 May 19.

17.

2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4.

Billamboz M, Suchaud V, Bailly F, Lion C, Andréola ML, Christ F, Debyser Z, Cotelle P.

Eur J Med Chem. 2016 Jul 19;117:256-68. doi: 10.1016/j.ejmech.2016.03.083. Epub 2016 Mar 28.

PMID:
27105029
18.

Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions.

Quercioli V, Di Primio C, Casini A, Mulder LCF, Vranckx LS, Borrenberghs D, Gijsbers R, Debyser Z, Cereseto A.

J Virol. 2016 Apr 29;90(10):5205-5209. doi: 10.1128/JVI.03188-15. Print 2016 May 15.

19.

Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex.

Gerits A, Vancraeyenest P, Vreysen S, Laramée ME, Michiels A, Gijsbers R, Van den Haute C, Moons L, Debyser Z, Baekelandt V, Arckens L, Vanduffel W.

Neurophotonics. 2015 Jul;2(3):031209. doi: 10.1117/1.NPh.2.3.031209. Epub 2015 Oct 1.

20.

An integrated multi-electrode-optrode array for in vitro optogenetics.

Welkenhuysen M, Hoffman L, Luo Z, De Proft A, Van den Haute C, Baekelandt V, Debyser Z, Gielen G, Puers R, Braeken D.

Sci Rep. 2016 Feb 2;6:20353. doi: 10.1038/srep20353.

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