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Items: 1 to 20 of 26

1.

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo.

Li M, de Graaf IA, van de Steeg E, de Jager MH, Groothuis GM.

Toxicol In Vitro. 2017 Apr;40:26-33. doi: 10.1016/j.tiv.2016.12.002. Epub 2016 Dec 7.

PMID:
27939799
2.

P-gp activity and inhibition in the different regions of human intestine ex vivo.

Li M, de Graaf IA, de Jager MH, Groothuis GM.

Biopharm Drug Dispos. 2017 Mar;38(2):127-138. doi: 10.1002/bdd.2047. Epub 2016 Nov 14.

PMID:
27757966
3.

Best cost-effectiveness and worker productivity with initial triple DMARD therapy compared with methotrexate monotherapy in early rheumatoid arthritis: cost-utility analysis of the tREACH trial.

de Jong PH, Hazes JM, Buisman LR, Barendregt PJ, van Zeben D, van der Lubbe PA, Gerards AH, de Jager MH, de Sonnaville PB, Grillet BA, Luime JJ, Weel AE.

Rheumatology (Oxford). 2016 Dec;55(12):2138-2147. Epub 2016 Aug 30.

PMID:
27581208
4.

The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices.

Li M, de Graaf IA, Siissalo S, de Jager MH, van Dam A, Groothuis GM.

Drug Metab Dispos. 2016 May;44(5):683-91. doi: 10.1124/dmd.115.068684. Epub 2016 Mar 1.

5.

Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.

Li M, de Graaf IA, de Jager MH, Groothuis GM.

Toxicol In Vitro. 2015 Aug;29(5):1070-8. doi: 10.1016/j.tiv.2015.04.011. Epub 2015 Apr 25.

PMID:
25917215
6.

Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties.

Bertrand B, Stefan L, Pirrotta M, Monchaud D, Bodio E, Richard P, Le Gendre P, Warmerdam E, de Jager MH, Groothuis GM, Picquet M, Casini A.

Inorg Chem. 2014 Feb 17;53(4):2296-303. doi: 10.1021/ic403011h. Epub 2014 Feb 5.

PMID:
24499428
7.

Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine.

Siissalo S, de Waard H, de Jager MH, Hayeshi R, Frijlink HW, Hinrichs WL, Dinter-Heidorn H, van Dam A, Proost JH, Groothuis GM, de Graaf IA.

Drug Metab Dispos. 2013 Aug;41(8):1557-65. doi: 10.1124/dmd.112.049585. Epub 2013 Jun 3.

8.

Role of ultrasonography in diagnosing early rheumatoid arthritis and remission of rheumatoid arthritis--a systematic review of the literature.

Ten Cate DF, Luime JJ, Swen N, Gerards AH, De Jager MH, Basoski NM, Hazes JM, Haagsma CJ, Jacobs JW.

Arthritis Res Ther. 2013 Jan 8;15(1):R4. doi: 10.1186/ar4132. Review.

9.

Induction therapy with a combination of DMARDs is better than methotrexate monotherapy: first results of the tREACH trial.

de Jong PH, Hazes JM, Barendregt PJ, Huisman M, van Zeben D, van der Lubbe PA, Gerards AH, de Jager MH, de Sonnaville PB, Grillet BA, Luime JJ, Weel AE.

Ann Rheum Dis. 2013 Jan;72(1):72-8. doi: 10.1136/annrheumdis-2011-201162. Epub 2012 Jun 7.

PMID:
22679301
10.

Treatment decisions and related costs differ significantly depending on the choice of a disease activity index in RA, according to 1987 and 2010 classification criteria.

de Jong PH, Hazes JM, van Zeben D, van der Lubbe PA, de Jager MH, de Sonnaville PB, Luime JJ, Weel AE.

Rheumatology (Oxford). 2012 Jul;51(7):1269-77. doi: 10.1093/rheumatology/kes008. Epub 2012 Feb 29.

PMID:
22378716
11.

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.

de Graaf IA, Olinga P, de Jager MH, Merema MT, de Kanter R, van de Kerkhof EG, Groothuis GM.

Nat Protoc. 2010 Sep;5(9):1540-51. doi: 10.1038/nprot.2010.111. Epub 2010 Aug 19.

PMID:
20725069
12.

Reduced ischemia-reoxygenation injury in rat intestine after luminal preservation with a tailored solution.

Roskott AM, Nieuwenhuijs VB, Leuvenink HG, Dijkstra G, Ottens P, de Jager MH, Gonalves Dias Pereira P, Fidler V, Groothuis GM, Ploeg RJ, de Graaf IA.

Transplantation. 2010 Sep 27;90(6):622-9. doi: 10.1097/TP.0b013e3181ebf796.

PMID:
20689496
13.

Patient preferences for treatment: report from a randomised comparison of treatment strategies in early rheumatoid arthritis (BeSt trial).

Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Allaart CF, Kerstens PJ, Grillet BA, de Jager MH, Han KH, Speyer I, van der Lubbe PA, Seys PE, Breedveld FC, Dijkmans BA.

Ann Rheum Dis. 2007 Sep;66(9):1227-32. Epub 2007 Apr 3.

14.

Induction of phase I and II drug metabolism in rat small intestine and colon in vitro.

van de Kerkhof EG, de Graaf IA, de Jager MH, Groothuis GM.

Drug Metab Dispos. 2007 Jun;35(6):898-907. Epub 2007 Mar 7.

15.

Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.

van de Kerkhof EG, Ungell AL, Sjöberg AK, de Jager MH, Hilgendorf C, de Graaf IA, Groothuis GM.

Drug Metab Dispos. 2006 Nov;34(11):1893-902. Epub 2006 Aug 16.

16.

Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.

de Graaf IA, de Kanter R, de Jager MH, Camacho R, Langenkamp E, van de Kerkhof EG, Groothuis GM.

Drug Metab Dispos. 2006 Apr;34(4):591-9. Epub 2006 Jan 13.

17.

Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies.

van de Kerkhof EG, de Graaf IA, de Jager MH, Meijer DK, Groothuis GM.

Drug Metab Dispos. 2005 Nov;33(11):1613-20. Epub 2005 Jul 28.

18.

A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies.

de Kanter R, Tuin A, van de Kerkhof E, Martignoni M, Draaisma AL, de Jager MH, de Graaf IA, Meijer DK, Groothuis GM.

J Pharmacol Toxicol Methods. 2005 Jan-Feb;51(1):65-72.

PMID:
15596116
19.

Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon.

De Kanter R, Monshouwer M, Draaisma AL, De Jager MH, de Graaf IA, Proost JH, Meijer DK, Groothuis GM.

Xenobiotica. 2004 Mar;34(3):229-41.

PMID:
15204696
20.

Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices.

De Kanter R, De Jager MH, Draaisma AL, Jurva JU, Olinga P, Meijer DK, Groothuis GM.

Xenobiotica. 2002 May;32(5):349-62.

PMID:
12065058

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