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Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

Ramaiahgari SC, Waidyanatha S, Dixon D, DeVito MJ, Paules RS, Ferguson SS.

Toxicol Sci. 2017 Nov 1;160(1):189-190. doi: 10.1093/toxsci/kfx194. No abstract available.


An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library.

Sipes NS, Wambaugh JF, Pearce R, Auerbach SS, Wetmore BA, Hsieh JH, Shapiro AJ, Svoboda D, DeVito MJ, Ferguson SS.

Environ Sci Technol. 2017 Sep 19;51(18):10786-10796. doi: 10.1021/acs.est.7b00650. Epub 2017 Sep 6.


From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.

Ramaiahgari SC, Waidyanatha S, Dixon D, DeVito MJ, Paules RS, Ferguson SS.

Toxicol Sci. 2017 Sep 1;159(1):124-136. doi: 10.1093/toxsci/kfx122.


Dose-response assessment of the dermal toxicity of Virginia cedarwood oil in F344/N rats and B6C3F1/N mice.

Catlin NR, Herbert R, Janardhan K, Hejtmancik MR, Fomby LM, Vallant M, Kissling GE, DeVito MJ.

Food Chem Toxicol. 2016 Dec;98(Pt B):159-168. doi: 10.1016/j.fct.2016.10.016. Epub 2016 Oct 18.


The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions.

Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS.

Environ Health Perspect. 2016 Nov;124(11):1671-1682. Epub 2016 Apr 19. Review.


Environmentally relevant pyrethroid mixtures: A study on the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to motor activity in the rat.

Hughes MF, Ross DG, Starr JM, Scollon EJ, Wolansky MJ, Crofton KM, DeVito MJ.

Toxicology. 2016 Jun 1;359-360:19-28. doi: 10.1016/j.tox.2016.06.013. Epub 2016 Jun 18.


An assessment of dioxin exposure across gestation and lactation using a PBPK model and new data from Seveso.

Emond C, DeVito M, Warner M, Eskenazi B, Mocarelli P, Birnbaum LS.

Environ Int. 2016 Jul-Aug;92-93:23-32. doi: 10.1016/j.envint.2016.03.015. Epub 2016 Apr 2.


Tissue time course and bioavailability of the pyrethroid insecticide bifenthrin in the Long-Evans rat.

Hughes MF, Ross DG, Edwards BC, DeVito MJ, Starr JM.

Xenobiotica. 2016;46(5):430-8. doi: 10.3109/00498254.2015.1081710. Epub 2015 Sep 14.


Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.

Bhusari S, Pandiri AR, Nagai H, Wang Y, Foley J, Hong HH, Ton TV, DeVito M, Shockley KR, Peddada SD, Gerrish KE, Malarkey DE, Hooth MJ, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2015 Dec;43(8):1114-26. doi: 10.1177/0192623315599853. Epub 2015 Aug 18.


F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgfβ Dysregulation.

Harvey JB, Hong HH, Bhusari S, Ton TV, Wang Y, Foley JF, Peddada SD, Hooth M, DeVito M, Nyska A, Pandiri AR, Hoenerhoff MJ.

Vet Pathol. 2016 Jan;53(1):170-81. doi: 10.1177/0300985815571680. Epub 2015 Mar 2.


Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice.

Frawley R, DeVito M, Walker NJ, Birnbaum L, White K Jr, Smith M, Maynor T, Recio L, Germolec D.

Toxicol Sci. 2014 Jun;139(2):488-500. doi: 10.1093/toxsci/kfu041. Epub 2014 Apr 8.


Environmentally relevant mixing ratios in cumulative assessments: a study of the kinetics of pyrethroids and their ester cleavage metabolites in blood and brain; and the effect of a pyrethroid mixture on the motor activity of rats.

Starr JM, Graham SE, Ross DG, Tornero-Velez R, Scollon EJ, Devito MJ, Crofton KM, Wolansky MJ, Hughes MF.

Toxicology. 2014 Jun 5;320:15-24. doi: 10.1016/j.tox.2014.02.016. Epub 2014 Mar 12.


In vitro metabolism of thyroxine by rat and human hepatocytes.

Richardson VM, Ferguson SS, Sey YM, Devito MJ.

Xenobiotica. 2014 May;44(5):391-403. doi: 10.3109/00498254.2013.847990. Epub 2013 Oct 31.


Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

Thomas RS, Philbert MA, Auerbach SS, Wetmore BA, Devito MJ, Cote I, Rowlands JC, Whelan MP, Hays SM, Andersen ME, Meek ME, Reiter LW, Lambert JC, Clewell HJ 3rd, Stephens ML, Zhao QJ, Wesselkamper SC, Flowers L, Carney EW, Pastoor TP, Petersen DD, Yauk CL, Nong A.

Toxicol Sci. 2013 Nov;136(1):4-18. doi: 10.1093/toxsci/kft178. Epub 2013 Aug 19.


Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review.

Taylor KW, Novak RF, Anderson HA, Birnbaum LS, Blystone C, Devito M, Jacobs D, Köhrle J, Lee DH, Rylander L, Rignell-Hydbom A, Tornero-Velez R, Turyk ME, Boyles AL, Thayer KA, Lind L.

Environ Health Perspect. 2013 Jul;121(7):774-83. doi: 10.1289/ehp.1205502. Epub 2013 May 7. Review.


Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds.

van den Berg M, Denison MS, Birnbaum LS, Devito MJ, Fiedler H, Falandysz J, Rose M, Schrenk D, Safe S, Tohyama C, Tritscher A, Tysklind M, Peterson RE.

Toxicol Sci. 2013 Jun;133(2):197-208. doi: 10.1093/toxsci/kft070. Epub 2013 Mar 14.


Mixtures research at NIEHS: an evolving program.

Rider CV, Carlin DJ, Devito MJ, Thompson CL, Walker NJ.

Toxicology. 2013 Nov 16;313(2-3):94-102. doi: 10.1016/j.tox.2012.10.017. Epub 2012 Nov 9.


Environmentally relevant mixtures in cumulative assessments: an acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids.

Starr JM, Scollon EJ, Hughes MF, Ross DG, Graham SE, Crofton KM, Wolansky MJ, Devito MJ, Tornero-Velez R.

Toxicol Sci. 2012 Dec;130(2):309-18. doi: 10.1093/toxsci/kfs245. Epub 2012 Aug 7.


A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application.

Tornero-Velez R, Davis J, Scollon EJ, Starr JM, Setzer RW, Goldsmith MR, Chang DT, Xue J, Zartarian V, DeVito MJ, Hughes MF.

Toxicol Sci. 2012 Nov;130(1):33-47. doi: 10.1093/toxsci/kfs236. Epub 2012 Aug 1.


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