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Items: 1 to 20 of 36


Capsaicinoids: Multiple effects on angiogenesis, invasion and metastasis in human cancers.

Friedman JR, Richbart SD, Merritt JC, Brown KC, Denning KL, Tirona MT, Valentovic MA, Miles SL, Dasgupta P.

Biomed Pharmacother. 2019 Aug 9;118:109317. doi: 10.1016/j.biopha.2019.109317. [Epub ahead of print] Review.


Capsaicinoids enhance chemosensitivity to chemotherapeutic drugs.

Friedman JR, Richbart SD, Merritt JC, Perry HE, Brown KC, Akers AT, Nolan NA, Stevenson CD, Hurley JD, Miles SL, Tirona MT, Valentovic MA, Dasgupta P.

Adv Cancer Res. 2019;144:263-298. doi: 10.1016/bs.acr.2019.05.002.


Acetylcholine signaling system in progression of lung cancers.

Friedman JR, Richbart SD, Merritt JC, Brown KC, Nolan NA, Akers AT, Lau JK, Robateau ZR, Miles SL, Dasgupta P.

Pharmacol Ther. 2019 Feb;194:222-254. doi: 10.1016/j.pharmthera.2018.10.002. Epub 2018 Oct 3. Review.


Anticancer Activity of Natural and Synthetic Capsaicin Analogs.

Friedman JR, Nolan NA, Brown KC, Miles SL, Akers AT, Colclough KW, Seidler JM, Rimoldi JM, Valentovic MA, Dasgupta P.

J Pharmacol Exp Ther. 2018 Mar;364(3):462-473. doi: 10.1124/jpet.117.243691. Epub 2017 Dec 15. Review.


Chronic exposure to electronic cigarettes results in impaired cardiovascular function in mice.

Olfert IM, DeVallance E, Hoskinson H, Branyan KW, Clayton S, Pitzer CR, Sullivan DP, Breit MJ, Wu Z, Klinkhachorn P, Mandler WK, Erdreich BH, Ducatman BS, Bryner RW, Dasgupta P, Chantler PD.

J Appl Physiol (1985). 2018 Mar 1;124(3):573-582. doi: 10.1152/japplphysiol.00713.2017. Epub 2017 Nov 2.


Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway.

Friedman JR, Perry HE, Brown KC, Gao Y, Lin J, Stevenson CD, Hurley JD, Nolan NA, Akers AT, Chen YC, Denning KL, Brown LG, Dasgupta P.

Biochem Pharmacol. 2017 Apr 1;129:54-66. doi: 10.1016/j.bcp.2017.01.004. Epub 2017 Jan 16.


Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers.

Hurley JD, Akers AT, Friedman JR, Nolan NA, Brown KC, Dasgupta P.

Cell Adh Migr. 2017 Jan 2;11(1):80-97. doi: 10.1080/19336918.2016.1187368. Epub 2016 May 19.


The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway.

Chen J, Chen AY, Huang H, Ye X, Rollyson WD, Perry HE, Brown KC, Rojanasakul Y, Rankin GO, Dasgupta P, Chen YC.

Int J Oncol. 2015;46(6):2629-38. doi: 10.3892/ijo.2015.2946. Epub 2015 Apr 1.


Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo.

Pillai S, Dasgupta P, Chellappan SP.

Methods Mol Biol. 2015;1288:429-46. doi: 10.1007/978-1-4939-2474-5_25.


Bioavailability of capsaicin and its implications for drug delivery.

Rollyson WD, Stover CA, Brown KC, Perry HE, Stevenson CD, McNees CA, Ball JG, Valentovic MA, Dasgupta P.

J Control Release. 2014 Dec 28;196:96-105. doi: 10.1016/j.jconrel.2014.09.027. Epub 2014 Oct 12. Review.


Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway.

Lau JK, Brown KC, Dom AM, Witte TR, Thornhill BA, Crabtree CM, Perry HE, Brown JM, Ball JG, Creel RG, Damron CL, Rollyson WD, Stevenson CD, Hardman WE, Valentovic MA, Carpenter AB, Dasgupta P.

Apoptosis. 2014 Aug;19(8):1190-201. doi: 10.1007/s10495-014-1007-y.


Nicotine induces the up-regulation of the α7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway.

Brown KC, Perry HE, Lau JK, Jones DV, Pulliam JF, Thornhill BA, Crabtree CM, Luo H, Chen YC, Dasgupta P.

J Biol Chem. 2013 Nov 15;288(46):33049-59. doi: 10.1074/jbc.M113.501601. Epub 2013 Oct 2.


Measurement of Acetylcholine from Cell Lines.

Lau JK, Brown KC, Dasgupta P.

Bio Protoc. 2013;3(24). pii: e1007. Epub 2013 Dec 20.


Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma.

Lau JK, Brown KC, Thornhill BA, Crabtree CM, Dom AM, Witte TR, Hardman WE, McNees CA, Stover CA, Carpenter AB, Luo H, Chen YC, Shiflett BS, Dasgupta P.

Cancer Res. 2013 Feb 15;73(4):1328-39. doi: 10.1158/0008-5472.CAN-12-3190. Epub 2012 Dec 7.


Nicotinic acetylcholine receptor signaling in atherogenesis.

Santanam N, Thornhill BA, Lau JK, Crabtree CM, Cook CR, Brown KC, Dasgupta P.

Atherosclerosis. 2012 Dec;225(2):264-73. doi: 10.1016/j.atherosclerosis.2012.07.041. Epub 2012 Aug 14. Review.


MG624, an α7-nAChR antagonist, inhibits angiogenesis via the Egr-1/FGF2 pathway.

Brown KC, Lau JK, Dom AM, Witte TR, Luo H, Crabtree CM, Shah YH, Shiflett BS, Marcelo AJ, Proper NA, Hardman WE, Egleton RD, Chen YC, Mangiarua EI, Dasgupta P.

Angiogenesis. 2012 Mar;15(1):99-114. doi: 10.1007/s10456-011-9246-9. Epub 2011 Dec 25. Erratum in: Angiogenesis. 2012 Jun;15(2):331. Dosage error in article text.


ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors.

Dasgupta P, Rizwani W, Pillai S, Davis R, Banerjee S, Hug K, Lloyd M, Coppola D, Haura E, Chellappan SP.

J Natl Cancer Inst. 2011 Feb 16;103(4):317-33. doi: 10.1093/jnci/djq541. Epub 2011 Jan 6.


The α7-nicotinic acetylcholine receptor and MMP-2/-9 pathway mediate the proangiogenic effect of nicotine in human retinal endothelial cells.

Dom AM, Buckley AW, Brown KC, Egleton RD, Marcelo AJ, Proper NA, Weller DE, Shah YH, Lau JK, Dasgupta P.

Invest Ophthalmol Vis Sci. 2011 Jun 22;52(7):4428-38. doi: 10.1167/iovs.10-5461.


Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway.

Brown KC, Witte TR, Hardman WE, Luo H, Chen YC, Carpenter AB, Lau JK, Dasgupta P.

PLoS One. 2010 Apr 20;5(4):e10243. doi: 10.1371/journal.pone.0010243.


Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo.

Pillai S, Dasgupta P, Chellappan SP.

Methods Mol Biol. 2009;523:323-39. doi: 10.1007/978-1-59745-190-1_22.


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