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Items: 1 to 20 of 66


Two strategies to engineer flexible loops for improved enzyme thermostability.

Yu H, Yan Y, Zhang C, Dalby PA.

Sci Rep. 2017 Feb 1;7:41212. doi: 10.1038/srep41212.


Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes.

Affaticati PE, Dai SB, Payongsri P, Hailes HC, Tittmann K, Dalby PA.

Sci Rep. 2016 Oct 21;6:35716. doi: 10.1038/srep35716.


Identification of Protein-Excipient Interaction Hotspots Using Computational Approaches.

Barata TS, Zhang C, Dalby PA, Brocchini S, Zloh M.

Int J Mol Sci. 2016 Jun 1;17(6). pii: E853. doi: 10.3390/ijms17060853.


Impact of cofactor-binding loop mutations on thermotolerance and activity of E. coli transketolase.

Morris P, Rios-Solis L, García-Arrazola R, Lye GJ, Dalby PA.

Enzyme Microb Technol. 2016 Jul;89:85-91. doi: 10.1016/j.enzmictec.2016.04.003. Epub 2016 Apr 4.


Mapping the Aggregation Kinetics of a Therapeutic Antibody Fragment.

Chakroun N, Hilton D, Ahmad SS, Platt GW, Dalby PA.

Mol Pharm. 2016 Feb 1;13(2):307-19. doi: 10.1021/acs.molpharmaceut.5b00387. Epub 2016 Jan 4.


Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase.

Deszcz D, Affaticati P, Ladkau N, Gegel A, Ward JM, Hailes HC, Dalby PA.

FEBS J. 2015 Jul;282(13):2512-26. doi: 10.1111/febs.13293. Epub 2015 Apr 23.


Second generation engineering of transketolase for polar aromatic aldehyde substrates.

Payongsri P, Steadman D, Hailes HC, Dalby PA.

Enzyme Microb Technol. 2015 Apr;71:45-52. doi: 10.1016/j.enzmictec.2015.01.008. Epub 2015 Jan 31.


The solution structures of two human IgG1 antibodies show conformational stability and accommodate their C1q and FcγR ligands.

Rayner LE, Hui GK, Gor J, Heenan RK, Dalby PA, Perkins SJ.

J Biol Chem. 2015 Mar 27;290(13):8420-38. doi: 10.1074/jbc.M114.631002. Epub 2015 Feb 6.


Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron.

Kranke P, Thompson JP, Dalby PL, Eberhart LH, Novikova E, Johnson BM, Russ SF, Noble R, Brigandi RA.

Br J Anaesth. 2015 Mar;114(3):423-9. doi: 10.1093/bja/aeu376. Epub 2014 Dec 8.


Identification and use of an alkane transporter plug-in for applications in biocatalysis and whole-cell biosensing of alkanes.

Grant C, Deszcz D, Wei YC, Martínez-Torres RJ, Morris P, Folliard T, Sreenivasan R, Ward J, Dalby P, Woodley JM, Baganz F.

Sci Rep. 2014 Jul 28;4:5844. doi: 10.1038/srep05844.


The Fab conformations in the solution structure of human immunoglobulin G4 (IgG4) restrict access to its Fc region: implications for functional activity.

Rayner LE, Hui GK, Gor J, Heenan RK, Dalby PA, Perkins SJ.

J Biol Chem. 2014 Jul 25;289(30):20740-56. doi: 10.1074/jbc.M114.572404. Epub 2014 May 29.


Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators..

N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839.


Optically induced thermal gradients for protein characterization in nanolitre-scale samples in microfluidic devices.

Sagar DM, Aoudjane S, Gaudet M, Aeppli G, Dalby PA.

Sci Rep. 2013;3:2130. doi: 10.1038/srep02130.


The solution structure of rabbit IgG accounts for its interactions with the Fc receptor and complement C1q and its conformational stability.

Rayner LE, Kadkhodayi-Kholghi N, Heenan RK, Gor J, Dalby PA, Perkins SJ.

J Mol Biol. 2013 Feb 8;425(3):506-23. doi: 10.1016/j.jmb.2012.11.019. Epub 2012 Nov 20.


Rational substrate and enzyme engineering of transketolase for aromatics.

Payongsri P, Steadman D, Strafford J, MacMurray A, Hailes HC, Dalby PA.

Org Biomol Chem. 2012 Dec 7;10(45):9021-9. doi: 10.1039/c2ob25751c. Epub 2012 Oct 19.


A generic hierarchical screening method for the analysis of microscale refolds using an automated robotic platform.

Ordidge GC, Mannall G, Liddell J, Dalby PA, Micheletti M.

Biotechnol Prog. 2012 Mar-Apr;28(2):435-44. doi: 10.1002/btpr.1502. Epub 2012 Jan 13.


Freeze drying formulation using microscale and design of experiment approaches: a case study using granulocyte colony-stimulating factor.

Grant Y, Matejtschuk P, Bird C, Wadhwa M, Dalby PA.

Biotechnol Lett. 2012 Apr;34(4):641-8. doi: 10.1007/s10529-011-0822-2. Epub 2011 Dec 21.


Directed evolution to re-adapt a co-evolved network within an enzyme.

Strafford J, Payongsri P, Hibbert EG, Morris P, Batth SS, Steadman D, Smith ME, Ward JM, Hailes HC, Dalby PA.

J Biotechnol. 2012 Jan;157(1):237-45. doi: 10.1016/j.jbiotec.2011.11.017. Epub 2011 Nov 29.


Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells.

Patterson R, Nerren J, Kogut M, Court P, Villarreal-Ramos B, Seyfert HM, Dalby P, Werling D.

Dev Comp Immunol. 2012 May;37(1):107-14. doi: 10.1016/j.dci.2011.10.009. Epub 2011 Oct 31.


Optimal synthesis of chromatographic trains for downstream protein processing.

Polykarpou EM, Dalby PA, Papageorgiou LG.

Biotechnol Prog. 2011 Nov-Dec;27(6):1653-60. doi: 10.1002/btpr.670. Epub 2011 Sep 21.


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