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Items: 1 to 20 of 34


P2Y₆ receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells.

Campwala H, Sexton DW, Crossman DC, Fountain SJ.

J Cell Sci. 2014 Nov 15;127(Pt 22):4964-73. doi: 10.1242/jcs.159012. Epub 2014 Sep 30.


The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study.

Morton AC, Rothman AM, Greenwood JP, Gunn J, Chase A, Clarke B, Hall AS, Fox K, Foley C, Banya W, Wang D, Flather MD, Crossman DC.

Eur Heart J. 2015 Feb 7;36(6):377-84. doi: 10.1093/eurheartj/ehu272. Epub 2014 Jul 30.


Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling.

Watson O, Novodvorsky P, Gray C, Rothman AM, Lawrie A, Crossman DC, Haase A, McMahon K, Gering M, Van Eeden FJ, Chico TJ.

Cardiovasc Res. 2013 Nov 1;100(2):252-61. doi: 10.1093/cvr/cvt170. Epub 2013 Jul 30.


Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.

Hameed AG, Arnold ND, Chamberlain J, Pickworth JA, Paiva C, Dawson S, Cross S, Long L, Zhao L, Morrell NW, Crossman DC, Newman CM, Kiely DG, Francis SE, Lawrie A.

J Exp Med. 2012 Oct 22;209(11):1919-35. doi: 10.1084/jem.20112716. Epub 2012 Oct 15.


Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension.

Condliffe R, Pickworth JA, Hopkinson K, Walker SJ, Hameed AG, Suntharaligam J, Soon E, Treacy C, Pepke-Zaba J, Francis SE, Crossman DC, Newman CM, Elliot CA, Morton AC, Morrell NW, Kiely DG, Lawrie A.

Pulm Circ. 2012 Jan-Mar;2(1):21-7. doi: 10.4103/2045-8932.94819.


Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner.

Lawrie A, Hameed AG, Chamberlain J, Arnold N, Kennerley A, Hopkinson K, Pickworth J, Kiely DG, Crossman DC, Francis SE.

Am J Pathol. 2011 Oct;179(4):1693-705. doi: 10.1016/j.ajpath.2011.06.037. Epub 2011 Aug 9.


Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina.

Bourke L, Tew GA, Milo M, Crossman DC, Saxton JM, Chico TJ.

BMC Public Health. 2010 Oct 18;10:620. doi: 10.1186/1471-2458-10-620.


Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.

Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I, Wilson HL.

J Biol Chem. 2010 Jul 23;285(30):23147-58. doi: 10.1074/jbc.M109.072793. Epub 2010 May 21.


A central role for monocytes in Toll-like receptor-mediated activation of the vasculature.

Ward JR, Francis SE, Marsden L, Suddason T, Lord GM, Dower SK, Crossman DC, Sabroe I.

Immunology. 2009 Sep;128(1):58-68. doi: 10.1111/j.1365-2567.2009.03071.x.


A novel mouse model of in situ stenting.

Chamberlain J, Wheatcroft M, Arnold N, Lupton H, Crossman DC, Gunn J, Francis S.

Cardiovasc Res. 2010 Jan 1;85(1):38-44. doi: 10.1093/cvr/cvp262.


Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding.

Chamberlain J, Francis S, Brookes Z, Shaw G, Graham D, Alp NJ, Dower S, Crossman DC.

PLoS One. 2009;4(4):e5073. doi: 10.1371/journal.pone.0005073. Epub 2009 Apr 6.


Translational mini-review series on immunology of vascular disease: inflammation, infections and Toll-like receptors in cardiovascular disease.

Ward JR, Wilson HL, Francis SE, Crossman DC, Sabroe I.

Clin Exp Immunol. 2009 Jun;156(3):386-94. doi: 10.1111/j.1365-2249.2009.03886.x. Epub 2009 Mar 20. Review.


Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.

Shah SH, Freedman NJ, Zhang L, Crosslin DR, Stone DH, Haynes C, Johnson J, Nelson S, Wang L, Connelly JJ, Muehlbauer M, Ginsburg GS, Crossman DC, Jones CJ, Vance J, Sketch MH, Granger CB, Newgard CB, Gregory SG, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER.

PLoS Genet. 2009 Jan;5(1):e1000318. doi: 10.1371/journal.pgen.1000318. Epub 2009 Jan 2.


Tribbles-2 is a novel regulator of inflammatory activation of monocytes.

Eder K, Guan H, Sung HY, Ward J, Angyal A, Janas M, Sarmay G, Duda E, Turner M, Dower SK, Francis SE, Crossman DC, Kiss-Toth E.

Int Immunol. 2008 Dec;20(12):1543-50. doi: 10.1093/intimm/dxn116. Epub 2008 Oct 24.


Genetic and functional association of FAM5C with myocardial infarction.

Connelly JJ, Shah SH, Doss JF, Gadson S, Nelson S, Crosslin DR, Hale AB, Lou X, Wang T, Haynes C, Seo D, Crossman DC, Mooser V, Granger CB, Jones CJ, Kraus WE, Hauser ER, Gregory SG.

BMC Med Genet. 2008 Apr 22;9:33. doi: 10.1186/1471-2350-9-33.


Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study).

Crossman DC, Morton AC, Gunn JP, Greenwood JP, Hall AS, Fox KA, Lucking AJ, Flather MD, Lees B, Foley CE.

Trials. 2008 Feb 25;9:8. doi: 10.1186/1745-6215-9-8.


Ischemia is not required for arteriogenesis in zebrafish embryos.

Gray C, Packham IM, Wurmser F, Eastley NC, Hellewell PG, Ingham PW, Crossman DC, Chico TJ.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2135-41. Epub 2007 Jul 26.


Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways.

Sung HY, Guan H, Czibula A, King AR, Eder K, Heath E, Suvarna SK, Dower SK, Wilson AG, Francis SE, Crossman DC, Kiss-Toth E.

J Biol Chem. 2007 Jun 22;282(25):18379-87. Epub 2007 Apr 23.


P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.

Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A, Crossman DC.

Br J Pharmacol. 2007 May;151(1):115-27. Epub 2007 Mar 12.


GATA2 is associated with familial early-onset coronary artery disease.

Connelly JJ, Wang T, Cox JE, Haynes C, Wang L, Shah SH, Crosslin DR, Hale AB, Nelson S, Crossman DC, Granger CB, Haines JL, Jones CJ, Vance JM, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER, Gregory SG.

PLoS Genet. 2006 Aug 25;2(8):e139. Epub 2006 Jul 20.

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