Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Stem Cells. 2010 Sep;28(9):1623-9. doi: 10.1002/stem.481.

Concise review: polarity in stem cells, disease, and aging.

Author information

1
Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.

Abstract

Adult somatic stem cells are central to homeostasis in tissues that present with a high cellular turnover like the skin, intestine, and the hematopoietic system. It is thought that polarity is particularly important with respect to fate decisions on stem cell division (symmetric or asymmetric) as well as for the maintenance of stem cell adhesion and quiescence (interaction with the niche). Consequently the failure to establish or regulate stem cell polarity might result in disease or tissue attrition. Members of the family of small RhoGTPases are known to exert an important role in regulating cell polarity. We summarize and discuss here recent views on the role of cell polarity in somatic stem cell function, aging, and disease, concluding that targeting cell polarity might be a novel approach to ameliorate or even revert aberrant somatic stem cell function.

PMID:
20641041
PMCID:
PMC2996084
DOI:
10.1002/stem.481
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center