Format

Send to

Choose Destination
  • Showing results for complete genome characterization of a newcastle disease virus isolates during an outbreak in sweden in 1995/virus genes. Your search for Complete genome characterisation of a Newcastle disease virus isolated during an outbreak in Sweden in 1995/oVirus genes retrieved no results.
Virus Genes. 2011 Oct;43(2):261-71. doi: 10.1007/s11262-011-0636-2. Epub 2011 Jun 12.

Whole genome sequencing and characterization of a virulent Newcastle disease virus isolated from an outbreak in Sweden.

Author information

1
The Department of Biomedical Sciences and Veterinary Public Health, Division of Virology and Parasitology and Joint Research and Development, National Veterinary Institute (SVA), Uppsala, Sweden. muhammad.munir@slu.se

Abstract

In this study, the complete genome sequence of a Newcastle disease virus (NDV) isolate collected from an outbreak in 1995 in chickens was fully characterized and compared with other NDV sequences. The genome was found to be 15,192 nucleotides long and to consist of six genes in the order 3'-NP-P-M-F-HN-L-5', similar to other avian paramyxoviruses type-I. However, a six-nucleotide insertion was observed in the 5' non-coding regions of the nucleoprotein (NP) gene, a feature that is unique to some NDV isolates. The isolate shows the amino acid sequence (112)RRQKRF(117) at the cleavage site of the F protein, which is identical to a known motif for virulent pathotypes of NDV. The phylogenetic analysis of the coding region of the F gene indicated that this isolate belongs to genotype VI, more specifically to genotype VId, along with isolates from the other European countries (Denmark, Switzerland and Austria). The same genotype caused outbreaks in the Middle East and Greece in the late 1960s, and in Hungary, in the early 1980s, suggesting a common source for these outbreaks.

PMID:
21667282
DOI:
10.1007/s11262-011-0636-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center