Format

Send to

Choose Destination

See 1 citation found by title matching your search:

J Bone Miner Res. 2018 Apr;33(4):569-579. doi: 10.1002/jbmr.3222. Epub 2017 Aug 7.

Comparative Analysis of the Radiology of Osteoporotic Vertebral Fractures in Women and Men: Cross-Sectional and Longitudinal Observations from the Canadian Multicentre Osteoporosis Study (CaMos).

Author information

1
Department of Radiology, University of British Columbia, Vancouver, Canada.
2
CaMos Methods Centre, Research Institute of the McGill University Health Centre, Montreal, Canada.
3
Department of Medical Imaging, University of Toronto,, and Sunnybrook Health Sciences Centre, Toronto, Canada.
4
Department of Medicine, Division of Rheumatology, CHU de Québec Research Centre, Laval University, Quebec City, Canada.
5
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
6
Faculty of Medicine, University of Toronto, and St. Michael's Hospital, Toronto, Canada.
7
Department of Medical Imaging, University of Toronto, Toronto, Canada.
8
Division of Endocrinology, University of British Columbia, Vancouver, Canada.
9
Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Canada.
10
Department of Medicine, University of Manitoba, Winnipeg, Canada.
11
Department of Medicine, Dalhousie University, Halifax, Canada.
12
Departments of Medicine, Community Health Sciences, and Oncology, University of Calgary, Calgary, Canada.
13
Department of Medicine, McMaster University, Hamilton, Canada.
14
Department of Medicine, Queen's University, Kingston, Canada.
15
A Priori Medical Sciences Inc., Victoria, Canada.
16
Department of Medicine and Joint Department of Medical Imaging, Centre of Excellence in Skeletal Health Assessment, University Health Network, University of Toronto, Toronto, Canada.
17
Department of Medicine, McGill University and McGill University Health Centre, Montreal, Canada.

Abstract

We compared two methods for osteoporotic vertebral fracture (VF) assessment on lateral spine radiographs, the Genant semiquantitative (GSQ) technique and a modified algorithm-based qualitative (mABQ) approach. We evaluated 4465 women and 1771 men aged ≥50 years from the Canadian Multicentre Osteoporosis Study with available X-ray images at baseline. Observer agreement was lowest for grade 1 VFs determined by GSQ. Among physician readers, agreement was greater for VFs diagnosed by mABQ (ranging from 0.62 [95% confidence interval (CI) 0.00-1.00] to 0.88 [0.76-1.00]) than by GSQ (ranging from 0.38 [0.17-0.60] to 0.69 [0.54-0.85]). GSQ VF prevalence (16.4% [95% CI 15.4-17.4]) and incidence (10.2/1000 person-years [9.2; 11.2]) were higher than with the mABQ method (prevalence 6.7% [6.1-7.4] and incidence 6.3/1000 person-years [5.5-7.1]). Women had more prevalent and incident VFs relative to men as defined by mABQ but not as defined by GSQ. Prevalent GSQ VFs were predominantly found in the mid-thoracic spine, whereas prevalent mABQ and incident VFs by both methods co-localized to the junction of the thoracic and lumbar spine. Prevalent mABQ VFs compared with GSQ VFs were more highly associated with reduced adjusted L1 to L4 bone mineral density (BMD) (-0.065 g/cm2 [-0.087 to -0.042]), femoral neck BMD (-0.051 g/cm2 [-0.065 to -0.036]), and total hip BMD (-0.059 g/cm2 [-0.076 to -0.041]). Prevalent mABQ VFs compared with prevalent GSQ were also more highly associated with incident VF by GSQ (odds ratio [OR] = 3.3 [2.2-5.0]), incident VF by mABQ (9.0 [5.3-15.3]), and incident non-vertebral major osteoporotic fractures (1.9 [1.2-3.0]). Grade 1 mABQ VFs, but not grade 1 GSQ VFs, were associated with incident non-vertebral major osteoporotic fractures (OR = 3.0 [1.4-6.5]). We conclude that defining VF by mABQ is preferred to the use of GSQ for clinical assessments.

KEYWORDS:

FRACTURE RISK; NON-VERTEBRAL FRACTURES; OSTEOPOROSIS; RADIOLOGY; VERTEBRAL FRACTURE PREVALENCE AND INCIDENCE

PMID:
28722766
DOI:
10.1002/jbmr.3222

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center