Collaboration through chromatin: motors of transcription and chromatin structure.
J Mol Biol. 2021.
PMID: 33556407
Free PMC article.
Review.
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Collaboration through chromatin: motors of transcription and chromatin structure.
J Mol Biol. 2021 Jul 9;433(14):166876. doi: 10.1016/j.jmb.2021.166876. Epub 2021 Feb 5.
J Mol Biol. 2021.
PMID: 33556407
Free PMC article.
Review.
Here we review what is known about the mechanisms of transcription on chromatin templates. Current models indicate that transcription through chromatin is accomplished by the combination of an inherent nucleosome disrupting activity of RNA polymerase a …
Here we review what is known about the mechanisms of transcription on chromatin templates. Current models indicate that tra …
Structure of nucleosome-bound human BAF complex.
Science. 2020 Feb 21;367(6480):875-881. doi: 10.1126/science.aaz9761. Epub 2020 Jan 30.
Science. 2020.
PMID: 32001526
Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their mutations are linked to cancers. ...Our study provides structural insi …
Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and polybromo-associated BAF (PBAF), regulate chro …
HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI.
Neurobiol Aging. 2020 Jun;90:99-109. doi: 10.1016/j.neurobiolaging.2020.02.006. Epub 2020 Feb 17.
Neurobiol Aging. 2020.
PMID: 32171589
Our laboratory has previously demonstrated that the deletion of Pten in aged animals diminishes the regenerative capacity in rubrospinal neurons. We hypothesize that changes in the chromatin structure might contribute to this age-associated decline. ...Interestingly …
Our laboratory has previously demonstrated that the deletion of Pten in aged animals diminishes the regenerative capacity in rubrospinal neu …
MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae.
Autophagy. 2018;14(9):1543-1561. doi: 10.1080/15548627.2018.1458171. Epub 2018 Aug 31.
Autophagy. 2018.
PMID: 29929416
Free PMC article.
MoSnt2 binds to promoters of autophagy genes MoATG6, 15, 16, and 22 to regulate their expression. In addition, MoTor controls MoSNT2 expression to regulate MoTor signaling which leads to autophagy and rice infection. Our study provides evidence of a direct link betw …
MoSnt2 binds to promoters of autophagy genes MoATG6, 15, 16, and 22 to regulate their expression. In addition, MoTor controls MoSNT2 …
The Chd1 Chromatin Remodeler Shifts Nucleosomal DNA Bidirectionally as a Monomer.
Mol Cell. 2017 Oct 5;68(1):76-88.e6. doi: 10.1016/j.molcel.2017.08.018. Epub 2017 Sep 21.
Mol Cell. 2017.
PMID: 28943314
Free PMC article.
Chromatin remodelers catalyze dynamic packaging of the genome by carrying out nucleosome assembly/disassembly, histone exchange, and nucleosome repositioning. ...We demonstrate that nucleosome sliding is tightly controlled by two regulatory domains: the DNA-binding domain, …
Chromatin remodelers catalyze dynamic packaging of the genome by carrying out nucleosome assembly/disassembly, histone exchange, and …
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