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Real-Time Binding Kinetic Analyses of the Interaction of the Dietary Stain Orange II with Dentin Matrix.

Alraies A, Cole DK, S Rees J, Glasse C, Young N, Waddington RJ, Sloan AJ.

J Dent. 2018 Jun 9. pii: S0300-5712(18)30154-4. doi: 10.1016/j.jdent.2018.06.001. [Epub ahead of print]


Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.

Tungatt K, Dolton G, Morgan SB, Attaf M, Fuller A, Whalley T, Hemmink JD, Porter E, Szomolay B, Montoya M, Hammond JA, Miles JJ, Cole DK, Townsend A, Bailey M, Rizkallah PJ, Charleston B, Tchilian E, Sewell AK.

PLoS Pathog. 2018 May 17;14(5):e1007017. doi: 10.1371/journal.ppat.1007017. eCollection 2018 May.


In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.

Holland CJ, MacLachlan BJ, Bianchi V, Hesketh SJ, Morgan R, Vickery O, Bulek AM, Fuller A, Godkin A, Sewell AK, Rizkallah PJ, Wells S, Cole DK.

Front Immunol. 2018 Apr 11;9:674. doi: 10.3389/fimmu.2018.00674. eCollection 2018.


Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

Miles JJ, Tan MP, Dolton G, Edwards ES, Galloway SA, Laugel B, Clement M, Makinde J, Ladell K, Matthews KK, Watkins TS, Tungatt K, Wong Y, Lee HS, Clark RJ, Pentier JM, Attaf M, Lissina A, Ager A, Gallimore A, Rizkallah PJ, Gras S, Rossjohn J, Burrows SR, Cole DK, Price DA, Sewell AK.

J Clin Invest. 2018 Apr 2;128(4):1569-1580. doi: 10.1172/JCI91512. Epub 2018 Mar 12.


Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.

Cole DK, Fuller A, Dolton G, Zervoudi E, Legut M, Miles K, Blanchfield L, Madura F, Holland CJ, Bulek AM, Bridgeman JS, Miles JJ, Schauenburg AJA, Beck K, Evavold BD, Rizkallah PJ, Sewell AK.

Front Immunol. 2017 Nov 10;8:1503. doi: 10.3389/fimmu.2017.01503. eCollection 2017.


Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation.

Jones N, Cronin JG, Dolton G, Panetti S, Schauenburg AJ, Galloway SAE, Sewell AK, Cole DK, Thornton CA, Francis NJ.

Front Immunol. 2017 Nov 9;8:1516. doi: 10.3389/fimmu.2017.01516. eCollection 2017.


Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.

Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA.

Nat Med. 2017 Dec;23(12):1416-1423. doi: 10.1038/nm.4444. Epub 2017 Nov 13.


T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus.

Bovay A, Zoete V, Dolton G, Bulek AM, Cole DK, Rizkallah PJ, Fuller A, Beck K, Michielin O, Speiser DE, Sewell AK, Fuertes Marraco SA.

Eur J Immunol. 2018 Feb;48(2):258-272. doi: 10.1002/eji.201747082. Epub 2017 Dec 11.


Thermal Stability of Heterotrimeric pMHC Proteins as Determined by Circular Dichroism Spectroscopy.

Fuller A, Wall A, Crowther MD, Lloyd A, Zhurov A, Sewell AK, Cole DK, Beck K.

Bio Protoc. 2017 Jul 5;7(13). pii: e2366. doi: 10.21769/BioProtoc.2366.


Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.

MacLachlan BJ, Greenshields-Watson A, Mason GH, Schauenburg AJ, Bianchi V, Rizkallah PJ, Sewell AK, Fuller A, Cole DK.

J Vis Exp. 2017 Feb 6;(120). doi: 10.3791/54991.


Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.

Cole DK, van den Berg HA, Lloyd A, Crowther MD, Beck K, Ekeruche-Makinde J, Miles JJ, Bulek AM, Dolton G, Schauenburg AJ, Wall A, Fuller A, Clement M, Laugel B, Rizkallah PJ, Wooldridge L, Sewell AK.

J Biol Chem. 2017 Jan 20;292(3):802-813. doi: 10.1074/jbc.M116.741603. Epub 2016 Nov 30.


Paediatric non-progression following grandmother-to-child HIV transmission.

Tsai MH, Muenchhoff M, Adland E, Carlqvist A, Roider J, Cole DK, Sewell AK, Carlson J, Ndung'u T, Goulder PJ.

Retrovirology. 2016 Sep 8;13(1):65. doi: 10.1186/s12977-016-0300-y.


Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Cole DK, Bulek AM, Dolton G, Schauenberg AJ, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles JJ, Peakman M, Wooldridge L, Rizkallah PJ, Sewell AK.

J Clin Invest. 2016 Sep 1;126(9):3626. doi: 10.1172/JCI89919. Epub 2016 Aug 15. No abstract available.


Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Cole DK, Bulek AM, Dolton G, Schauenberg AJ, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles JJ, Peakman M, Wooldridge L, Rizkallah PJ, Sewell AK.

J Clin Invest. 2016 Jun 1;126(6):2191-204. doi: 10.1172/JCI85679. Epub 2016 May 16. Erratum in: J Clin Invest. 2016 Sep 1;126(9):3626.


A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.

Bianchi V, Bulek A, Fuller A, Lloyd A, Attaf M, Rizkallah PJ, Dolton G, Sewell AK, Cole DK.

J Biol Chem. 2016 Apr 22;291(17):8951-9. doi: 10.1074/jbc.M115.707414. Epub 2016 Feb 25.


T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones.

Theaker SM, Rius C, Greenshields-Watson A, Lloyd A, Trimby A, Fuller A, Miles JJ, Cole DK, Peakman M, Sewell AK, Dolton G.

J Immunol Methods. 2016 Mar;430:43-50. doi: 10.1016/j.jim.2016.01.014. Epub 2016 Jan 28.


Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.

Raman MC, Rizkallah PJ, Simmons R, Donnellan Z, Dukes J, Bossi G, Le Provost GS, Todorov P, Baston E, Hickman E, Mahon T, Hassan N, Vuidepot A, Sami M, Cole DK, Jakobsen BK.

Sci Rep. 2016 Jan 13;6:18851. doi: 10.1038/srep18851.


Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers.

Holland CJ, Dolton G, Scurr M, Ladell K, Schauenburg AJ, Miners K, Madura F, Sewell AK, Price DA, Cole DK, Godkin AJ.

J Immunol. 2015 Dec 15;195(12):5827-36. doi: 10.4049/jimmunol.1402787. Epub 2015 Nov 9.


The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphoma.

Jones K, Wockner L, Brennan RM, Keane C, Chattopadhyay PK, Roederer M, Price DA, Cole DK, Hassan B, Beck K, Gottlieb D, Ritchie DS, Seymour JF, Vari F, Crooks P, Burrows SR, Gandhi MK.

Clin Exp Immunol. 2016 Feb;183(2):206-20. doi: 10.1111/cei.12716. Epub 2015 Nov 13.


Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide.

Motozono C, Pearson JA, De Leenheer E, Rizkallah PJ, Beck K, Trimby A, Sewell AK, Wong FS, Cole DK.

J Biol Chem. 2015 Jul 31;290(31):18924-33. doi: 10.1074/jbc.M114.622522. Epub 2015 Jun 17.

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