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Items: 1 to 20 of 114

1.

Plasmodium glyceraldehyde-3-phosphate dehydrogenase: A potential malaria diagnostic target.

Krause RGE, Hurdayal R, Choveaux D, Przyborski JM, Coetzer THT, Goldring JPD.

Exp Parasitol. 2017 Aug;179:7-19. doi: 10.1016/j.exppara.2017.05.007. Epub 2017 May 26.

PMID:
28552792
2.

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.

Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators.

N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17.

PMID:
28304242
3.

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease.

Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA, Kuder JF, Wang H, Liu T, Wasserman SM, Sever PS, Pedersen TR; FOURIER Steering Committee and Investigators.

N Engl J Med. 2017 May 4;376(18):1713-1722. doi: 10.1056/NEJMoa1615664. Epub 2017 Mar 17.

PMID:
28304224
4.

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

Singh K, Okombo J, Brunschwig C, Ndubi F, Barnard L, Wilkinson C, Njogu PM, Njoroge M, Laing L, Machado M, Prudêncio M, Reader J, Botha M, Nondaba S, Birkholtz LM, Lauterbach S, Churchyard A, Coetzer TL, Burrows JN, Yeates C, Denti P, Wiesner L, Egan TJ, Wittlin S, Chibale K.

J Med Chem. 2017 Feb 23;60(4):1432-1448. doi: 10.1021/acs.jmedchem.6b01641. Epub 2017 Feb 7.

PMID:
28094524
5.

Plasmodium falciparum exhibits markers of regulated cell death at high population density in vitro.

Engelbrecht D, Coetzer TL.

Parasitol Int. 2016 Dec;65(6 Pt A):715-727. doi: 10.1016/j.parint.2016.07.007. Epub 2016 Jul 15.

PMID:
27425600
6.

A systematic review of pentacyclic triterpenes and their derivatives as chemotherapeutic agents against tropical parasitic diseases.

Isah MB, Ibrahim MA, Mohammed A, Aliyu AB, Masola B, Coetzer TH.

Parasitology. 2016 Sep;143(10):1219-31. doi: 10.1017/S0031182016000718. Epub 2016 May 31.

PMID:
27240847
7.

Discovering New Transmission-Blocking Antimalarial Compounds: Challenges and Opportunities.

Birkholtz LM, Coetzer TL, Mancama D, Leroy D, Alano P.

Trends Parasitol. 2016 Sep;32(9):669-81. doi: 10.1016/j.pt.2016.04.017. Epub 2016 May 18. Review.

PMID:
27209388
8.

Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues.

Vieira WA, Coetzer TL.

Malar J. 2016 Jan 20;15:32. doi: 10.1186/s12936-015-1065-9.

9.

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.

Le Manach C, Paquet T, Brunschwig C, Njoroge M, Han Z, Gonzàlez Cabrera D, Bashyam S, Dhinakaran R, Taylor D, Reader J, Botha M, Churchyard A, Lauterbach S, Coetzer TL, Birkholtz LM, Meister S, Winzeler EA, Waterson D, Witty MJ, Wittlin S, Jiménez-Díaz MB, Santos Martínez M, Ferrer S, Angulo-Barturen I, Street LJ, Chibale K.

J Med Chem. 2015 Nov 12;58(21):8713-22. doi: 10.1021/acs.jmedchem.5b01605. Epub 2015 Nov 2.

PMID:
26502160
10.

Sunlight inhibits growth and induces markers of programmed cell death in Plasmodium falciparum in vitro.

Engelbrecht D, Coetzer TL.

Malar J. 2015 Sep 29;14:378. doi: 10.1186/s12936-015-0867-0.

11.

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.

Reader J, Botha M, Theron A, Lauterbach SB, Rossouw C, Engelbrecht D, Wepener M, Smit A, Leroy D, Mancama D, Coetzer TL, Birkholtz LM.

Malar J. 2015 May 22;14:213. doi: 10.1186/s12936-015-0718-z.

12.

The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning.

Hull R, Oosthuysen B, Cajee UF, Mokgohloa L, Nweke E, Antunes RJ, Coetzer TH, Ntwasa M.

Int J Mol Sci. 2015 May 6;16(5):10242-66. doi: 10.3390/ijms160510242.

13.

Intrinsic disorder within the erythrocyte binding-like proteins from Plasmodium falciparum.

Blanc M, Coetzer TL, Blackledge M, Haertlein M, Mitchell EP, Forsyth VT, Jensen MR.

Biochim Biophys Acta. 2014 Dec;1844(12):2306-14. doi: 10.1016/j.bbapap.2014.09.023. Epub 2014 Oct 5.

PMID:
25288451
14.

Turning up the heat: heat stress induces markers of programmed cell death in Plasmodium falciparum in vitro.

Engelbrecht D, Coetzer TL.

Cell Death Dis. 2013 Dec 19;4:e971. doi: 10.1038/cddis.2013.505.

15.

Phylogenetic analysis of the polyprotein coding region of an infectious South African bursal disease virus (IBDV) strain.

Vukea PR, Willows-Munro S, Horner RF, Coetzer TH.

Infect Genet Evol. 2014 Jan;21:279-86. doi: 10.1016/j.meegid.2013.11.017. Epub 2013 Dec 1.

PMID:
24291011
16.

Recombinant expression and biochemical characterisation of two alanyl aminopeptidases of Trypanosoma congolense.

Pillay D, Boulangé AF, Coustou V, Baltz T, Coetzer TH.

Exp Parasitol. 2013 Dec;135(4):675-84. doi: 10.1016/j.exppara.2013.10.005. Epub 2013 Oct 28.

PMID:
24177338
17.

Novel exon 2 α spectrin mutation and intragenic crossover: three morphological phenotypes associated with four distinct α spectrin defects.

Swierczek S, Agarwal AM, Naidoo K, Lorenzo FR, Whisenant J, Nussenzveig RH, Agarwal N, Coetzer TL, Prchal JT.

Haematologica. 2013 Dec;98(12):1972-9. doi: 10.3324/haematol.2013.086629. Epub 2013 Sep 27.

18.

Vedolizumab as induction and maintenance therapy for Crohn's disease.

Sandborn WJ, Feagan BG, Rutgeerts P, Hanauer S, Colombel JF, Sands BE, Lukas M, Fedorak RN, Lee S, Bressler B, Fox I, Rosario M, Sankoh S, Xu J, Stephens K, Milch C, Parikh A; GEMINI 2 Study Group.

N Engl J Med. 2013 Aug 22;369(8):711-21. doi: 10.1056/NEJMoa1215739.

19.

Vedolizumab as induction and maintenance therapy for ulcerative colitis.

Feagan BG, Rutgeerts P, Sands BE, Hanauer S, Colombel JF, Sandborn WJ, Van Assche G, Axler J, Kim HJ, Danese S, Fox I, Milch C, Sankoh S, Wyant T, Xu J, Parikh A; GEMINI 1 Study Group.

N Engl J Med. 2013 Aug 22;369(8):699-710. doi: 10.1056/NEJMoa1215734.

20.

Reduced glycerol incorporation into phospholipids contributes to impaired intra-erythrocytic growth of glycerol kinase knockout Plasmodium falciparum parasites.

Naidoo K, Coetzer TL.

Biochim Biophys Acta. 2013 Nov;1830(11):5326-34. doi: 10.1016/j.bbagen.2013.08.006. Epub 2013 Aug 16.

PMID:
23954205

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