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A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies.
Wasielewska JM, Chaves JCS, Johnston RL, Milton LA, Hernández D, Chen L, Song J, Lee W, Leinenga G, Nisbet RM, Pébay A, Götz J, White AR, Oikari LE. Wasielewska JM, et al. Theranostics. 2022 Sep 25;12(16):6826-6847. doi: 10.7150/thno.72685. eCollection 2022. Theranostics. 2022. PMID: 36276649 Free PMC article.
We established mono- and co-culture models of human sporadic AD and control BBB cells to investigate the effects of FUS(+MB) on BBB cell phenotype and to screen for the delivery of two potentially therapeutic AD antibodies, an Aducanumab-analogue (Aduhelm(TM); anti-amyloid-beta) …
We established mono- and co-culture models of human sporadic AD and control BBB cells to investigate the effects of FUS(+MB) on BBB cell phe …