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Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.

Barnes MD, Winkler ML, Taracila MA, Page MG, Desarbre E, Kreiswirth BN, Shields RK, Nguyen MH, Clancy C, Spellberg B, Papp-Wallace KM, Bonomo RA.

MBio. 2017 Oct 31;8(5). pii: e00528-17. doi: 10.1128/mBio.00528-17.


Ceftolozane-Tazobactam for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infections: Clinical Effectiveness and Evolution of Resistance.

Haidar G, Philips NJ, Shields RK, Snyder D, Cheng S, Potoski BA, Doi Y, Hao B, Press EG, Cooper VS, Clancy CJ, Nguyen MH.

Clin Infect Dis. 2017 Jul 1;65(1):110-120. doi: 10.1093/cid/cix182.


Wall/Object Punching: An Important but Under-Recognized Form of Nonsuicidal Self-Injury.

Kimbrel NA, Thomas SP, Hicks TA, Hertzberg MA, Clancy CP, Elbogen EB, Meyer EC, DeBeer BB, Gross GM, Silvia PJ, Morissette SB, Gratz KL, Calhoun PS, Beckham JC.

Suicide Life Threat Behav. 2017 Sep 19. doi: 10.1111/sltb.12371. [Epub ahead of print]


Dynamics of sodium current mediated early afterdepolarizations.

Sato D, Clancy CE, Bers DM.

Heliyon. 2017 Sep 6;3(9):e00388. doi: 10.1016/j.heliyon.2017.e00388. eCollection 2017 Sep.


Unraveling Drug Penetration of Echinocandin Antifungals at the Site of Infection in an Intra-abdominal Abscess Model.

Zhao Y, Prideaux B, Nagasaki Y, Lee MH, Chen PY, Blanc L, Ho H, Clancy CJ, Nguyen MH, Dartois V, Perlin DS.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01009-17. doi: 10.1128/AAC.01009-17. Print 2017 Oct.


Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature.

Shields RK, Nguyen MH, Press EG, Chen L, Kreiswirth BN, Clancy CJ.

Open Forum Infect Dis. 2017 Jul 1;4(3):ofx101. doi: 10.1093/ofid/ofx101. eCollection 2017 Summer.


Effects of Isavuconazole on the Plasma Concentrations of Tacrolimus among Solid-Organ Transplant Patients.

Rivosecchi RM, Clancy CJ, Shields RK, Ensor CR, Shullo MA, Falcione BA, Venkataramanan R, Nguyen MH.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00970-17. doi: 10.1128/AAC.00970-17. Print 2017 Sep.


A model comparison approach to trauma-related guilt as a mediator of the relationship between PTSD symptoms and suicidal ideation among veterans.

Cunningham KC, Farmer C, LoSavio ST, Dennis PA, Clancy CP, Hertzberg MA, Collie CF, Calhoun PS, Beckham JC.

J Affect Disord. 2017 Oct 15;221:227-231. doi: 10.1016/j.jad.2017.06.046. Epub 2017 Jun 21.


Identifying Spectra of Activity and Therapeutic Niches for Ceftazidime-Avibactam and Imipenem-Relebactam against Carbapenem-Resistant Enterobacteriaceae.

Haidar G, Clancy CJ, Chen L, Samanta P, Shields RK, Kreiswirth BN, Nguyen MH.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00642-17. doi: 10.1128/AAC.00642-17. Print 2017 Sep.


Patterns of Opioid Prescription and Use After Cesarean Delivery.

Bateman BT, Cole NM, Maeda A, Burns SM, Houle TT, Huybrechts KF, Clancy CR, Hopp SB, Ecker JL, Ende H, Grewe K, Raposo Corradini B, Schoenfeld RE, Sankar K, Day LJ, Harris L, Booth JL, Flood P, Bauer ME, Tsen LC, Landau R, Leffert LR.

Obstet Gynecol. 2017 Jul;130(1):29-35. doi: 10.1097/AOG.0000000000002093.


Ceftazidime-Avibactam Is Superior to Other Treatment Regimens against Carbapenem-Resistant Klebsiella pneumoniae Bacteremia.

Shields RK, Nguyen MH, Chen L, Press EG, Potoski BA, Marini RV, Doi Y, Kreiswirth BN, Clancy CJ.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00883-17. doi: 10.1128/AAC.00883-17. Print 2017 Aug.


A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias.

Yang PC, Perissinotti LL, López-Redondo F, Wang Y, DeMarco KR, Jeng MT, Vorobyov I, Harvey RD, Kurokawa J, Noskov SY, Clancy CE.

J Physiol. 2017 Jul 15;595(14):4695-4723. doi: 10.1113/JP273142. Epub 2017 Jun 14.


Gram-Negative Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group.

Doi Y, Bonomo RA, Hooper DC, Kaye KS, Johnson JR, Clancy CJ, Thaden JT, Stryjewski ME, van Duin D; Gram-Negative Committee of the Antibacterial Resistance Leadership Group (ARLG)a.

Clin Infect Dis. 2017 Mar 15;64(suppl_1):S30-S35. doi: 10.1093/cid/ciw829.


A meta-analysis of the efficacy of prophylactic alpha-blockade for the prevention of urinary retention following primary unilateral inguinal hernia repair.

Clancy C, Coffey JC, O'Riordain MG, Burke JP.

Am J Surg. 2017 Mar 14. pii: S0002-9610(17)30020-X. doi: 10.1016/j.amjsurg.2017.02.017. [Epub ahead of print]


In Vitro Selection of Meropenem Resistance among Ceftazidime-Avibactam-Resistant, Meropenem-Susceptible Klebsiella pneumoniae Isolates with Variant KPC-3 Carbapenemases.

Shields RK, Nguyen MH, Press EG, Chen L, Kreiswirth BN, Clancy CJ.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e00079-17. doi: 10.1128/AAC.00079-17. Print 2017 May.


Mutations in blaKPC-3 That Confer Ceftazidime-Avibactam Resistance Encode Novel KPC-3 Variants That Function as Extended-Spectrum β-Lactamases.

Haidar G, Clancy CJ, Shields RK, Hao B, Cheng S, Nguyen MH.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02534-16. doi: 10.1128/AAC.02534-16. Print 2017 May.


Effects of active feedback gait retraining to produce a medial weight transfer at the foot in subjects with symptomatic medial knee osteoarthritis.

Erhart-Hledik JC, Asay JL, Clancy C, Chu CR, Andriacchi TP.

J Orthop Res. 2017 Oct;35(10):2251-2259. doi: 10.1002/jor.23527. Epub 2017 Feb 9.


A Framework for Disseminating Clinical Best Practices in the VA Health System.

Elnahal SM, Clancy CM, Shulkin DJ.

JAMA. 2017 Jan 17;317(3):255-256. doi: 10.1001/jama.2016.18764. No abstract available.


Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections.

Shields RK, Chen L, Cheng S, Chavda KD, Press EG, Snyder A, Pandey R, Doi Y, Kreiswirth BN, Nguyen MH, Clancy CJ.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02097-16. doi: 10.1128/AAC.02097-16. Print 2017 Mar.


Emergence of Candida auris: An International Call to Arms.

Clancy CJ, Nguyen MH.

Clin Infect Dis. 2017 Jan 15;64(2):141-143. doi: 10.1093/cid/ciw696. Epub 2016 Oct 20. No abstract available.


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