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Items: 1 to 20 of 52


Reappraisal of the clinical effect of mepolizumab - Authors' reply.

Chupp GL, Bradford ES, Albers FC, Bratton DJ, Wang-Jairaj J, Nelsen LM, Trevor JL, Magnan A.

Lancet Respir Med. 2017 Jun;5(6):e21. doi: 10.1016/S2213-2600(17)30184-4. Epub 2017 May 26. No abstract available.


A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expression.

Yan X, Liang A, Gomez J, Cohn L, Zhao H, Chupp GL.

BMC Bioinformatics. 2017 Jun 20;18(1):309. doi: 10.1186/s12859-017-1727-4.


Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial.

Chupp GL, Bradford ES, Albers FC, Bratton DJ, Wang-Jairaj J, Nelsen LM, Trevor JL, Magnan A, Ten Brinke A.

Lancet Respir Med. 2017 May;5(5):390-400. doi: 10.1016/S2213-2600(17)30125-X. Epub 2017 Apr 5.


Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients.

Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg CM, Girodet PO, Berger P, Kline JN, Chupp G, Susulic VS, Barnathan ES, Baribaud F, Loza MJ; Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study investigators.

J Allergy Clin Immunol. 2017 Jan 13. pii: S0091-6749(17)30007-6. doi: 10.1016/j.jaci.2016.11.038. [Epub ahead of print]


Multiparameter Single Cell Profiling of Airway Inflammatory Cells.

Yao Y, Welp T, Liu Q, Niu N, Wang X, Britto CJ, Krishnaswamy S, Chupp GL, Montgomery RR.

Cytometry B Clin Cytom. 2017 Jan;92(1):12-20. doi: 10.1002/cyto.b.21491.


Sputum Gene Expression of IL-13 Receptor α2 Chain Correlates with Airflow Obstruction and Helper T-Cell Type 2 Inflammation in Asthma.

Nezgovorova V, Liu Q, Hu B, Villalobos JL, Yan X, Niu N, Holm C, Grant NP, Marone S, Ravage-Mass L, Lee CG, Elias JA, Cohn L, Chupp GL.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S96-7. doi: 10.1513/AnnalsATS.201509-611MG.


Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma.

Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S104-5. doi: 10.1513/AnnalsATS.201510-681MG.


Nasal Microbiome Composition Is Associated with Chitotriosidase (Chit1) Activity in Adult Hutterites.

Igartua C, Davenport ER, Chupp GL, Elias JA, Gilad Y, Ober C, Pinto JM.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S100-1. doi: 10.1513/AnnalsATS.201508-521MG. No abstract available.


Integrated analyses of gene expression and genetic association studies in a founder population.

Cusanovich DA, Caliskan M, Billstrand C, Michelini K, Chavarria C, De Leon S, Mitrano A, Lewellyn N, Elias JA, Chupp GL, Lang RM, Shah SJ, Decara JM, Gilad Y, Ober C.

Hum Mol Genet. 2016 May 15;25(10):2104-2112. Epub 2016 Feb 29.


Future Research Directions in Asthma. An NHLBI Working Group Report.

Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA Jr, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC.

Am J Respir Crit Care Med. 2015 Dec 1;192(11):1366-72. doi: 10.1164/rccm.201505-0963WS. Review.


Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma.

Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL.

Am J Respir Crit Care Med. 2015 May 15;191(10):1116-25. doi: 10.1164/rccm.201408-1440OC.


The promise and peril of functional genomics in chronic obstructive pulmonary disease.

Chupp GL, Washko GR.

Am J Respir Crit Care Med. 2015 Mar 1;191(5):497-9. doi: 10.1164/rccm.201501-0104ED. No abstract available.


Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation.

Ahangari F, Sood A, Ma B, Takyar S, Schuyler M, Qualls C, Dela Cruz CS, Chupp GL, Lee CG, Elias JA.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):746-57. doi: 10.1164/rccm.201405-0796OC.


Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.

Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N; Severe Asthma Research Program (SARP) Investigators, Cohn L, Chupp GL.

J Allergy Clin Immunol. 2015 Jul;136(1):51-58.e10. doi: 10.1016/j.jaci.2014.11.027. Epub 2015 Jan 13.


Hospital readmission after pulmonary lobectomy is not affected by surgical approach.

Assi R, Wong DJ, Boffa DJ, Detterbeck FC, Wang Z, Chupp GL, Kim AW.

Ann Thorac Surg. 2015 Feb;99(2):393-8. doi: 10.1016/j.athoracsur.2014.10.014. Epub 2014 Dec 12.


IL-6 receptor α defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma.

Lee N, You S, Shin MS, Lee WW, Kang KS, Kim SH, Kim WU, Homer RJ, Kang MJ, Montgomery RR, Dela Cruz CS, Shaw AC, Lee PJ, Chupp GL, Hwang D, Kang I.

Am J Respir Crit Care Med. 2014 Dec 15;190(12):1383-94. doi: 10.1164/rccm.201403-0601OC.


Role of growth arrest-specific gene 6 in the development of fungal allergic airway disease in mice.

Shibata T, Ismailoglu UB, Kittan NA, Moreira AP, Coelho AL, Chupp GL, Kunkel SL, Lukacs NW, Hogaboam CM.

Am J Respir Cell Mol Biol. 2014 Nov;51(5):615-25. doi: 10.1165/rcmb.2014-0049OC.


The role of mepolizumab in atopic and nonatopic severe asthma with persistent eosinophilia.

Ortega H, Chupp G, Bardin P, Bourdin A, Garcia G, Hartley B, Yancey S, Humbert M.

Eur Respir J. 2014 Jul;44(1):239-41. doi: 10.1183/09031936.00220413. Epub 2014 Mar 23. No abstract available.


Improvement in asthma control and inflammation in children undergoing adenotonsillectomy.

Levin JC, Gagnon L, He X, Baum ED, Karas DE, Chupp GL.

Pediatr Res. 2014 Mar;75(3):403-8. doi: 10.1038/pr.2013.237. Epub 2013 Dec 12.


Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma.

Gavala ML, Kelly EA, Esnault S, Kukreja S, Evans MD, Bertics PJ, Chupp GL, Jarjour NN.

Clin Exp Allergy. 2013 Feb;43(2):187-97. doi: 10.1111/cea.12032.

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