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SLC30A8 mutations in type 2 diabetes.

Rutter GA, Chimienti F.

Diabetologia. 2015 Jan;58(1):31-6. doi: 10.1007/s00125-014-3405-7. Review.


Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells.

Gerber PA, Bellomo EA, Hodson DJ, Meur G, Solomou A, Mitchell RK, Hollinshead M, Chimienti F, Bosco D, Hughes SJ, Johnson PR, Rutter GA.

Diabetologia. 2014 Aug;57(8):1635-44. doi: 10.1007/s00125-014-3266-0.


Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K(ATP) channels from both α-cells and δ-cells.

Cheng-Xue R, Gómez-Ruiz A, Antoine N, Noël LA, Chae HY, Ravier MA, Chimienti F, Schuit FC, Gilon P.

Diabetes. 2013 May;62(5):1612-22. doi: 10.2337/db12-0347.


Zinc, pancreatic islet cell function and diabetes: new insights into an old story.

Chimienti F.

Nutr Res Rev. 2013 Jun;26(1):1-11. doi: 10.1017/S0954422412000212. Review.


Zinc transporters and their role in the pancreatic β-cell.

Lemaire K, Chimienti F, Schuit F.

J Diabetes Investig. 2012 Jun 6;3(3):202-11. doi: 10.1111/j.2040-1124.2012.00199.x. Review.


Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8.

Hardy AB, Wijesekara N, Genkin I, Prentice KJ, Bhattacharjee A, Kong D, Chimienti F, Wheeler MB.

Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1084-96. doi: 10.1152/ajpendo.00448.2011.


Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model.

Hardy AB, Serino AS, Wijesekara N, Chimienti F, Wheeler MB.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:112-7. doi: 10.1111/j.1463-1326.2011.01451.x. Review.


Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro.

Bozym RA, Chimienti F, Giblin LJ, Gross GW, Korichneva I, Li Y, Libert S, Maret W, Parviz M, Frederickson CJ, Thompson RB.

Exp Biol Med (Maywood). 2010 Jun;235(6):741-50. doi: 10.1258/ebm.2010.009258.


Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

Wijesekara N, Dai FF, Hardy AB, Giglou PR, Bhattacharjee A, Koshkin V, Chimienti F, Gaisano HY, Rutter GA, Wheeler MB.

Diabetologia. 2010 Aug;53(8):1656-68. doi: 10.1007/s00125-010-1733-9.


Zinc, a regulator of islet function and glucose homeostasis.

Wijesekara N, Chimienti F, Wheeler MB.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:202-14. doi: 10.1111/j.1463-1326.2009.01110.x. Review.


Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

Lemaire K, Ravier MA, Schraenen A, Creemers JW, Van de Plas R, Granvik M, Van Lommel L, Waelkens E, Chimienti F, Rutter GA, Gilon P, in't Veld PA, Schuit FC.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14872-7. doi: 10.1073/pnas.0906587106.


Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. doi: 10.2337/db09-0551.


Prion protein protects against zinc-mediated cytotoxicity by modifying intracellular exchangeable zinc and inducing metallothionein expression.

Rachidi W, Chimienti F, Aouffen M, Senator A, Guiraud P, Seve M, Favier A.

J Trace Elem Med Biol. 2009;23(3):214-23. doi: 10.1016/j.jtemb.2009.02.007.


Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?

Egefjord L, Jensen JL, Bang-Berthelsen CH, Petersen AB, Smidt K, Schmitz O, Karlsen AE, Pociot F, Chimienti F, Rungby J, Magnusson NE.

BMC Endocr Disord. 2009 Feb 25;9:7. doi: 10.1186/1472-6823-9-7.


Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.

Gyulkhandanyan AV, Lu H, Lee SC, Bhattacharjee A, Wijesekara N, Fox JE, MacDonald PE, Chimienti F, Dai FF, Wheeler MB.

J Biol Chem. 2008 Apr 11;283(15):10184-97. doi: 10.1074/jbc.M707005200.


In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion.

Chimienti F, Devergnas S, Pattou F, Schuit F, Garcia-Cuenca R, Vandewalle B, Kerr-Conte J, Van Lommel L, Grunwald D, Favier A, Seve M.

J Cell Sci. 2006 Oct 15;119(Pt 20):4199-206.


Resveratrol enhances UVA-induced DNA damage in HaCaT human keratinocytes.

Seve M, Chimienti F, Devergnas S, Aouffen M, Douki T, Chantegrel J, Cadet J, Favier A.

Med Chem. 2005 Nov;1(6):629-33.


ZnT-8, a pancreatic beta-cell-specific zinc transporter.

Chimienti F, Favier A, Seve M.

Biometals. 2005 Aug;18(4):313-7. Review.


Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study.

Devergnas S, Chimienti F, Naud N, Pennequin A, Coquerel Y, Chantegrel J, Favier A, Seve M.

Biochem Pharmacol. 2004 Aug 15;68(4):699-709.

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