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Items: 1 to 20 of 184

1.

Exposure of patients to ionising radiation during lung cancer diagnostic work-up.

Rintoul RC, Atherton R, Tweed K, Yates S, Chilvers ER.

Thorax. 2017 Apr 25. pii: thoraxjnl-2016-209641. doi: 10.1136/thoraxjnl-2016-209641. [Epub ahead of print]

PMID:
28442554
2.

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.

3.

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espéli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G, Smith KG.

J Exp Med. 2017 Apr 3;214(4):1111-1128. doi: 10.1084/jem.20161382. Epub 2017 Mar 28.

4.

Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma.

Farahi N, Paige E, Balla J, Prudence E, Ferreira RC, Southwood M, Appleby SL, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Silverman EK, Cho MH, Danesh J, Paul DS, Freitag DF, Chilvers ER.

Hum Mol Genet. 2017 Apr 15;26(8):1584-1596. doi: 10.1093/hmg/ddx053.

5.

Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.

Koop G, Vrieling M, Storisteanu DM, Lok LS, Monie T, van Wigcheren G, Raisen C, Ba X, Gleadall N, Hadjirin N, Timmerman AJ, Wagenaar JA, Klunder HM, Fitzgerald JR, Zadoks R, Paterson GK, Torres C, Waller AS, Loeffler A, Loncaric I, Hoet AE, Bergström K, De Martino L, Pomba C, de Lencastre H, Ben Slama K, Gharsa H, Richardson EJ, Chilvers ER, de Haas C, van Kessel K, van Strijp JA, Harrison EM, Holmes MA.

Sci Rep. 2017 Jan 20;7:40660. doi: 10.1038/srep40660.

6.

Quantification of Lung PET Images: Challenges and Opportunities.

Chen DL, Cheriyan J, Chilvers ER, Choudhury G, Coello C, Connell M, Fisk M, Groves AM, Gunn RN, Holman BF, Hutton BF, Lee S, MacNee W, Mohan D, Parr D, Subramanian D, Tal-Singer R, Thielemans K, van Beek EJ, Vass L, Wellen JW, Wilkinson I, Wilson FJ.

J Nucl Med. 2017 Feb;58(2):201-207. doi: 10.2967/jnumed.116.184796. Epub 2017 Jan 12. Review.

PMID:
28082432
7.

Hypoxia causes IL-8 secretion, Charcot Leyden crystal formation, and suppression of corticosteroid-induced apoptosis in human eosinophils.

Porter LM, Cowburn AS, Farahi N, Deighton J, Farrow SN, Fiddler CA, Juss JK, Condliffe AM, Chilvers ER.

Clin Exp Allergy. 2016 Dec 21. doi: 10.1111/cea.12877. [Epub ahead of print]

PMID:
28000962
8.

Evasion of Neutrophil Extracellular Traps by Respiratory Pathogens.

Storisteanu DM, Pocock JM, Cowburn AS, Juss JK, Nadesalingam A, Nizet V, Chilvers ER.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):423-431. doi: 10.1165/rcmb.2016-0193PS.

PMID:
27854516
9.

Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection.

Lodge KM, Thompson AA, Chilvers ER, Condliffe AM.

Microbes Infect. 2017 Mar;19(3):166-176. doi: 10.1016/j.micinf.2016.10.005. Epub 2016 Oct 24.

PMID:
27789256
10.

Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium.

Appleby SL, Mitrofan CG, Crosby A, Hoenderdos K, Lodge K, Upton PD, Yates CM, Nash GB, Chilvers ER, Morrell NW.

J Immunol. 2016 Oct 15;197(8):3302-3314. Epub 2016 Sep 19.

11.

Circulating granulocyte lifespan in compensated alcohol-related cirrhosis: a pilot study.

Potts JR, Farahi N, Heard S, Chilvers ER, Verma S, Peters AM.

Physiol Rep. 2016 Sep;4(17). pii: e12836. doi: 10.14814/phy2.12836.

12.

Hypoxia upregulates neutrophil degranulation and potential for tissue injury.

Hoenderdos K, Lodge KM, Hirst RA, Chen C, Palazzo SG, Emerenciana A, Summers C, Angyal A, Porter L, Juss JK, O'Callaghan C, Chilvers ER, Condliffe AM.

Thorax. 2016 Nov;71(11):1030-1038. doi: 10.1136/thoraxjnl-2015-207604. Epub 2016 Aug 31.

13.

Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit.

Summers C, Singh NR, Worpole L, Simmonds R, Babar J, Condliffe AM, Gunning KE, Johnston AJ, Chilvers ER.

Thorax. 2016 Nov;71(11):1050-1051. doi: 10.1136/thoraxjnl-2016-208402. Epub 2016 Aug 22.

14.

Severe Colitis Associated with Pirfenidone Use in Idiopathic Pulmonary Fibrosis.

Fiddler CA, Simler N, Parfrey H, Miremadi A, Chilvers ER.

Ann Am Thorac Soc. 2016 Aug;13(8):1430-2. doi: 10.1513/AnnalsATS.201602-118LE. No abstract available.

PMID:
27509160
15.

C13orf31 (FAMIN) is a central regulator of immunometabolic function.

Cader MZ, Boroviak K, Zhang Q, Assadi G, Kempster SL, Sewell GW, Saveljeva S, Ashcroft JW, Clare S, Mukhopadhyay S, Brown KP, Tschurtschenthaler M, Raine T, Doe B, Chilvers ER, Griffin JL, Kaneider NC, Floto RA, D'Amato M, Bradley A, Wakelam MJ, Dougan G, Kaser A.

Nat Immunol. 2016 Sep;17(9):1046-56. doi: 10.1038/ni.3532. Epub 2016 Aug 1.

PMID:
27478939
16.

The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion.

Fiddler CA, Parfrey H, Cowburn AS, Luo D, Nash GB, Murphy G, Chilvers ER.

PLoS One. 2016 Jul 28;11(7):e0160108. doi: 10.1371/journal.pone.0160108. eCollection 2016.

17.

HIF2α-arginase axis is essential for the development of pulmonary hypertension.

Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8801-6. doi: 10.1073/pnas.1602978113. Epub 2016 Jul 18.

18.

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.

Juss JK, House D, Amour A, Begg M, Herre J, Storisteanu DM, Hoenderdos K, Bradley G, Lennon M, Summers C, Hessel EM, Condliffe A, Chilvers ER.

Am J Respir Crit Care Med. 2016 Oct 15;194(8):961-973.

19.

Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome.

Juss J, Herre J, Begg M, Bradley G, Lennon M, Amour A, House D, Hessel EM, Summers C, Condliffe AM, Chilvers ER.

Lancet. 2015 Feb 26;385 Suppl 1:S55. doi: 10.1016/S0140-6736(15)60370-1.

PMID:
26312877
20.

TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.

Radjabova V, Mastroeni P, Skjødt K, Zaccone P, de Bono B, Goodall JC, Chilvers ER, Juss JK, Jones DC, Trowsdale J, Barrow AD.

J Immunol. 2015 Oct 1;195(7):3149-59. doi: 10.4049/jimmunol.1401847. Epub 2015 Aug 26.

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