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Items: 1 to 20 of 56

1.

Genome editing of human embryos: to edit or not to edit, that is the question.

Chandrasegaran S, Bullen CK, Carroll D.

J Clin Invest. 2017 Oct 2;127(10):3588-3590. doi: 10.1172/JCI96962. Epub 2017 Aug 28. No abstract available.

2.

Design of a synthetic yeast genome.

Richardson SM, Mitchell LA, Stracquadanio G, Yang K, Dymond JS, DiCarlo JE, Lee D, Huang CL, Chandrasegaran S, Cai Y, Boeke JD, Bader JS.

Science. 2017 Mar 10;355(6329):1040-1044. doi: 10.1126/science.aaf4557.

PMID:
28280199
3.

The Era of Synthetic Biology and Genome Engineering: Where No Man Has Gone Before.

Lu TK, Chandrasegaran S, Hodak H.

J Mol Biol. 2016 Feb 27;428(5 Pt B):835-6. doi: 10.1016/j.jmb.2016.01.025. Epub 2016 Jan 29. No abstract available.

PMID:
26827726
4.

Origins of Programmable Nucleases for Genome Engineering.

Chandrasegaran S, Carroll D.

J Mol Biol. 2016 Feb 27;428(5 Pt B):963-89. doi: 10.1016/j.jmb.2015.10.014. Epub 2015 Oct 23. Review.

5.

Erratum to: Rewriting the blueprint of life by synthetic genomics and genome engineering.

Annaluru N, Ramalingam S, Chandrasegaran S.

Genome Biol. 2015 Aug 7;16:159. doi: 10.1186/s13059-015-0703-4. No abstract available.

6.

Rewriting the blueprint of life by synthetic genomics and genome engineering.

Annaluru N, Ramalingam S, Chandrasegaran S.

Genome Biol. 2015 Jun 16;16:125. doi: 10.1186/s13059-015-0689-y. Review. Erratum in: Genome Biol. 2015;16:159.

7.

TALEN-mediated generation and genetic correction of disease-specific human induced pluripotent stem cells.

Ramalingam S, Annaluru N, Kandavelou K, Chandrasegaran S.

Curr Gene Ther. 2014;14(6):461-72.

PMID:
25245091
8.

Total synthesis of a functional designer eukaryotic chromosome.

Annaluru N, Muller H, Mitchell LA, Ramalingam S, Stracquadanio G, Richardson SM, Dymond JS, Kuang Z, Scheifele LZ, Cooper EM, Cai Y, Zeller K, Agmon N, Han JS, Hadjithomas M, Tullman J, Caravelli K, Cirelli K, Guo Z, London V, Yeluru A, Murugan S, Kandavelou K, Agier N, Fischer G, Yang K, Martin JA, Bilgel M, Bohutski P, Boulier KM, Capaldo BJ, Chang J, Charoen K, Choi WJ, Deng P, DiCarlo JE, Doong J, Dunn J, Feinberg JI, Fernandez C, Floria CE, Gladowski D, Hadidi P, Ishizuka I, Jabbari J, Lau CY, Lee PA, Li S, Lin D, Linder ME, Ling J, Liu J, Liu J, London M, Ma H, Mao J, McDade JE, McMillan A, Moore AM, Oh WC, Ouyang Y, Patel R, Paul M, Paulsen LC, Qiu J, Rhee A, Rubashkin MG, Soh IY, Sotuyo NE, Srinivas V, Suarez A, Wong A, Wong R, Xie WR, Xu Y, Yu AT, Koszul R, Bader JS, Boeke JD, Chandrasegaran S.

Science. 2014 Apr 4;344(6179):55-8. doi: 10.1126/science.1249252. Epub 2014 Mar 27. Erratum in: Science. 2014 May 23;344(6186):816.

9.

A CRISPR way to engineer the human genome.

Ramalingam S, Annaluru N, Chandrasegaran S.

Genome Biol. 2013 Feb 26;14(2):107. doi: 10.1186/gb-2013-14-2-107. Review.

10.

Generation and genetic engineering of human induced pluripotent stem cells using designed zinc finger nucleases.

Ramalingam S, London V, Kandavelou K, Cebotaru L, Guggino W, Civin C, Chandrasegaran S.

Stem Cells Dev. 2013 Feb 15;22(4):595-610. doi: 10.1089/scd.2012.0245. Epub 2012 Oct 19.

11.

The Build-a-Genome course.

Cooper EM, Müller H, Chandrasegaran S, Bader JS, Boeke JD.

Methods Mol Biol. 2012;852:273-83. doi: 10.1007/978-1-61779-564-0_20.

PMID:
22328440
12.

Assembling large DNA segments in yeast.

Muller H, Annaluru N, Schwerzmann JW, Richardson SM, Dymond JS, Cooper EM, Bader JS, Boeke JD, Chandrasegaran S.

Methods Mol Biol. 2012;852:133-50. doi: 10.1007/978-1-61779-564-0_11.

PMID:
22328431
13.

Assembling DNA fragments by USER fusion.

Annaluru N, Muller H, Ramalingam S, Kandavelou K, London V, Richardson SM, Dymond JS, Cooper EM, Bader JS, Boeke JD, Chandrasegaran S.

Methods Mol Biol. 2012;852:77-95. doi: 10.1007/978-1-61779-564-0_7.

PMID:
22328427
14.

Synthetic chromosome arms function in yeast and generate phenotypic diversity by design.

Dymond JS, Richardson SM, Coombes CE, Babatz T, Muller H, Annaluru N, Blake WJ, Schwerzmann JW, Dai J, Lindstrom DL, Boeke AC, Gottschling DE, Chandrasegaran S, Bader JS, Boeke JD.

Nature. 2011 Sep 14;477(7365):471-6. doi: 10.1038/nature10403.

15.

Creating designed zinc-finger nucleases with minimal cytotoxicity.

Ramalingam S, Kandavelou K, Rajenderan R, Chandrasegaran S.

J Mol Biol. 2011 Jan 21;405(3):630-41. doi: 10.1016/j.jmb.2010.10.043. Epub 2010 Nov 19.

16.

Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells.

Meister GE, Chandrasegaran S, Ostermeier M.

Nucleic Acids Res. 2010 Mar;38(5):1749-59. doi: 10.1093/nar/gkp1126. Epub 2009 Dec 9.

17.

Targeted manipulation of mammalian genomes using designed zinc finger nucleases.

Kandavelou K, Ramalingam S, London V, Mani M, Wu J, Alexeev V, Civin CI, Chandrasegaran S.

Biochem Biophys Res Commun. 2009 Oct 9;388(1):56-61. doi: 10.1016/j.bbrc.2009.07.112. Epub 2009 Jul 25.

18.

Custom-designed molecular scissors for site-specific manipulation of the plant and mammalian genomes.

Kandavelou K, Chandrasegaran S.

Methods Mol Biol. 2009;544:617-36. doi: 10.1007/978-1-59745-483-4_40.

19.

Teaching synthetic biology, bioinformatics and engineering to undergraduates: the interdisciplinary Build-a-Genome course.

Dymond JS, Scheifele LZ, Richardson S, Lee P, Chandrasegaran S, Bader JS, Boeke JD.

Genetics. 2009 Jan;181(1):13-21. doi: 10.1534/genetics.108.096784. Epub 2008 Nov 17.

20.

An engineered split M.HhaI-zinc finger fusion lacks the intended methyltransferase specificity.

Meister GE, Chandrasegaran S, Ostermeier M.

Biochem Biophys Res Commun. 2008 Dec 5;377(1):226-30. doi: 10.1016/j.bbrc.2008.09.099. Epub 2008 Oct 1.

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