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Items: 20


New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition.

Zhang Z, Cellitti J, Teriete P, Pellecchia M, Stec B.

Biochimie. 2015 Jan;108:186-92. doi: 10.1016/j.biochi.2014.11.012. Epub 2014 Nov 27.


Identification of a novel Mcl-1 protein binding motif.

Placzek WJ, Sturlese M, Wu B, Cellitti JF, Wei J, Pellecchia M.

J Biol Chem. 2011 Nov 18;286(46):39829-35. doi: 10.1074/jbc.M111.305326. Epub 2011 Sep 27.


SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.

Rega MF, Wu B, Wei J, Zhang Z, Cellitti JF, Pellecchia M.

J Med Chem. 2011 Sep 8;54(17):6000-13. doi: 10.1021/jm200826s. Epub 2011 Aug 4.


Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase.

De SK, Barile E, Chen V, Stebbins JL, Cellitti JF, Machleidt T, Carlson CB, Yang L, Dahl R, Pellecchia M.

Bioorg Med Chem. 2011 Apr 15;19(8):2582-8. doi: 10.1016/j.bmc.2011.03.017. Epub 2011 Mar 12.


Inhibitors of Protein Folding: DnaK.

Cellitti J, Zhang Z, Wang S, Wu B, Guiney D, Pellecchia M.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Jan 15 [updated 2010 Sep 2].


Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.

Monfardini I, Huang JW, Beck B, Cellitti JF, Pellecchia M, Dömling A.

J Med Chem. 2011 Feb 10;54(3):890-900. Epub 2011 Jan 11.


Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Wei J, Kitada S, Stebbins JL, Placzek W, Zhai D, Wu B, Rega MF, Zhang Z, Cellitti J, Yang L, Dahl R, Reed JC, Pellecchia M.

J Med Chem. 2010 Nov 25;53(22):8000-11. doi: 10.1021/jm100746q. Epub 2010 Oct 29.


BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Wei J, Stebbins JL, Kitada S, Dash R, Placzek W, Rega MF, Wu B, Cellitti J, Zhai D, Yang L, Dahl R, Fisher PB, Reed JC, Pellecchia M.

J Med Chem. 2010 May 27;53(10):4166-76. doi: 10.1021/jm1001265.


Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors.

De SK, Chen V, Stebbins JL, Chen LH, Cellitti JF, Machleidt T, Barile E, Riel-Mehan M, Dahl R, Yang L, Emdadi A, Murphy R, Pellecchia M.

Bioorg Med Chem. 2010 Jan 15;18(2):590-6. doi: 10.1016/j.bmc.2009.12.013. Epub 2009 Dec 11.


The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam.

Leone M, Cellitti J, Pellecchia M.

BMC Struct Biol. 2009 Sep 18;9:59. doi: 10.1186/1472-6807-9-59.


Small molecule DnaK modulators targeting the beta-domain.

Cellitti J, Zhang Z, Wang S, Wu B, Yuan H, Hasegawa P, Guiney DG, Pellecchia M.

Chem Biol Drug Des. 2009 Oct;74(4):349-57. doi: 10.1111/j.1747-0285.2009.00869.x. Epub 2009 Aug 20.


Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Wei J, Kitada S, Rega MF, Stebbins JL, Zhai D, Cellitti J, Yuan H, Emdadi A, Dahl R, Zhang Z, Yang L, Reed JC, Pellecchia M.

J Med Chem. 2009 Jul 23;52(14):4511-23. doi: 10.1021/jm900472s.


Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.

Wei J, Kitada S, Rega MF, Emdadi A, Yuan H, Cellitti J, Stebbins JL, Zhai D, Sun J, Yang L, Dahl R, Zhang Z, Wu B, Wang S, Reed TA, Wang HG, Lawrence N, Sebti S, Reed JC, Pellecchia M.

Mol Cancer Ther. 2009 Apr;8(4):904-13. doi: 10.1158/1535-7163.MCT-08-1050. Erratum in: Mol Cancer Ther. 2009 Jul 1;8(7):2076. Wang, Hong-Gang [added].


NMR studies of a heterotypic Sam-Sam domain association: the interaction between the lipid phosphatase Ship2 and the EphA2 receptor.

Leone M, Cellitti J, Pellecchia M.

Biochemistry. 2008 Dec 2;47(48):12721-8. doi: 10.1021/bi801713f.


Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors.

Huang JW, Zhang Z, Wu B, Cellitti JF, Zhang X, Dahl R, Shiau CW, Welsh K, Emdadi A, Stebbins JL, Reed JC, Pellecchia M.

J Med Chem. 2008 Nov 27;51(22):7111-8. doi: 10.1021/jm8006992.


Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.

Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13. doi: 10.1073/pnas.0805677105. Epub 2008 Oct 15.


A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors.

Yip KW, Godoi PH, Zhai D, Garcia X, Cellitti JF, Cuddy M, Gerlic M, Chen Y, Satterthwait A, Vasile S, Sergienko E, Reed JC.

J Biomol Screen. 2008 Aug;13(7):665-73. doi: 10.1177/1087057108320918. Epub 2008 Jul 14.


Development of paramagnetic probes for molecular recognition studies in protein kinases.

Vazquez J, De SK, Chen LH, Riel-Mehan M, Emdadi A, Cellitti J, Stebbins JL, Rega MF, Pellecchia M.

J Med Chem. 2008 Jun 26;51(12):3460-5. doi: 10.1021/jm800068w.


Exploring subdomain cooperativity in T4 lysozyme I: structural and energetic studies of a circular permutant and protein fragment.

Cellitti J, Llinas M, Echols N, Shank EA, Gillespie B, Kwon E, Crowder SM, Dahlquist FW, Alber T, Marqusee S.

Protein Sci. 2007 May;16(5):842-51. Epub 2007 Mar 30.


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